Combating Antibiotic Resistance: Mechanisms, Multidrug-Resistant Pathogens, and Novel Therapeutic Approaches: An Updated Review

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 402 - 402

Published: March 12, 2025

The escalating global health crisis of antibiotic resistance, driven by the rapid emergence multidrug-resistant (MDR) bacterial pathogens, necessitates urgent and innovative countermeasures. This review comprehensively examines diverse mechanisms employed bacteria to evade action, including alterations in cell membrane permeability, efflux pump overexpression, biofilm formation, target site modifications, enzymatic degradation antibiotics. Specific focus is given transport systems such as ATP-binding cassette (ABC) transporters, resistance–nodulation–division (RND) pumps, major facilitator superfamily (MFS) multidrug toxic compound extrusion (MATE) systems, small resistance (SMR) families, proteobacterial antimicrobial (PACE) families. Additionally, explores burden MDR pathogens evaluates emerging therapeutic strategies, quorum quenching (QQ), probiotics, postbiotics, synbiotics, peptides (AMPs), stem applications, immunotherapy, antibacterial photodynamic therapy (aPDT), bacteriophage. Furthermore, this discusses novel agents, animal-venom-derived compounds nanobiotics, promising alternatives conventional interplay between clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR-associated proteins (Cas) adaptive immunity analyzed, revealing opportunities for targeted genetic interventions. By synthesizing current advancements underscores necessity interdisciplinary collaboration among biomedical scientists, researchers, pharmaceutical industry drive development agents. Ultimately, comprehensive analysis provides a roadmap future research, emphasizing need sustainable cooperative approaches combat safeguard health.

Language: Английский

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Microalgae in health care and functional foods: β-glucan applications, innovations in drug delivery and synthetic biology

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 4, 2025

Microalgae are emerging as a key player in healthcare, functional foods, and sustainable biotech due to their capacity produce bioactive compounds like β-glucans, omega-3 fatty acids, antioxidants an eco-friendly manner. This review comprehensively discusses the role of microalgae healthcare focusing particularly on β-glucan therapeutics, drug delivery innovations, synthetic biology applications. In microalgae-derived show immense promise for treating diseases, boosting immunity, tackling oxidative stress. Euglena -derived paramylon, type β-glucan, has shown potential various medical applications, including immunomodulation anticancer therapy. Synthetic bioprocess engineering enhancing microalgae’s therapeutic nutritional value, with applications personalized medicine. To maximize microalgae, further research development needed address scalability, regulatory alignment, consumer acceptance, focus interdisciplinary collaboration practices align innovation environmental conservation.

Language: Английский

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Co-firing of sewage sludge and microalgae blends as solid fuel additives for industrial burners

Sustainable Energy Technologies and Assessments, Journal Year: 2025, Volume and Issue: 77, P. 104322 - 104322

Published: April 16, 2025

Language: Английский

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Unraveling the potential of Chlorella vulgaris in sustainable bioplastic production, carbon sequestration, and wastewater treatment using integrated approaches

Journal of Environmental Science and Health Part A, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8

Published: April 28, 2025

With rising concerns over plastic pollution and climate change, microalgae-based bioplastics offer a promising alternative to petroleum-derived plastics. This study explores the dual role of Chlorella vulgaris in bioplastic synthesis environmental remediation through its cultivation wastewater-fed bioreactor. By leveraging wastewater as nutrient source, C. achieved biomass yield 3.472 g/L, with 20 mg/L polyhydroxyalkanoate (PHA) extracted. Fourier Transform Infrared (FTIR) spectroscopy validated presence PHA-specific ester functional groups, confirming suitability for applications. Additionally, process resulted complete reduction free CO2 within three days, demonstrating efficient carbon sequestration. Significant declines contaminants, including COD, BOD, nitrogen, phosphorus, highlight microalga's bioremediation capabilities, making it candidate sustainable treatment. introduces cost-efficient, self-sustaining microalgal bioprocess that eliminates need synthetic nutrients while achieving high-yield PHA production, sequestration, detoxification. integrating essential sustainability goals- capture, water purification- this work bridges gap between bio-based materials conservation. The results affirm multifunctional bioresource supports both biopolymer change mitigation. advances biotechnology by potential large-scale, closed-loop biomanufacturing, providing an eco-friendly, scalable solution reducing waste greenhouse gas emissions promoting industrial practices.

Language: Английский

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Phycoremediation of dairy industry wastewater using Chlorella sorokiniana: a cost-effective strategy for biodiesel production

Environmental Science and Pollution Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Language: Английский

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