A novel label-free biosensor for myocardial ischemia biomarker detection via CRISPR/12a DOI

Chunping Liu,

Qiaojing Liu,

Xiaoling Chen

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 270, P. 116954 - 116954

Published: Nov. 17, 2024

Language: Английский

Endothelial Colony-Forming Cells (ECFCs) in Cerebrovascular Aging: Focus on the Pathogenesis of Vascular Cognitive Impairment and Dementia (VCID), and Treatment Prospects DOI
Sharon Negri,

Zeke Reyff,

Eva Troyano-Rodriguez

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102672 - 102672

Published: Jan. 1, 2025

Language: Английский

Citations

2
Genomic instability and genetic heterogeneity in aging: insights from clonal hematopoiesis (CHIP), monoclonal gammopathy (MGUS), and monoclonal B-cell lymphocytosis (MBL) DOI Creative Commons

Attila Kállai,

Zoltán Ungvári, Mónika Fekete

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Aging is a multifaceted process characterized by gradual decline in physiological function and increased susceptibility to range of chronic diseases. Among the molecular cellular mechanisms driving aging, genomic instability fundamental hallmark, contributing mutation load genetic heterogeneity within populations. This review explores role aging hematopoietic system, with particular focus on clonal hematopoiesis indeterminate potential (CHIP), monoclonal gammopathy undetermined significance (MGUS), B-cell lymphocytosis (MBL) as biomarkers. CHIP involves expansion stem cells somatic mutations. In contrast, MGUS presence plasma producing immunoglobulins, while MBL proliferation B cells. These conditions are prevalent population serve measurable indicators underlying instability. Studying these entities offers valuable insights into which mutations accumulate drive evolution providing deeper understanding how impacts tissue homeostasis. summary, system serves powerful model for investigating interplay between aging. Incorporating age-related hematological research, alongside other biomarkers such epigenetic clocks, can enhance precision predictive power biological age assessments. provide comprehensive view process, facilitating early detection diseases hopefully enabling personalized healthcare strategies.

Language: Английский

Citations

7
Clonal hematopoiesis of indeterminate potential: recent developments and perspectives DOI
Meiqi Guo, Yuan Li, Baobing Zhao

et al.

Current Opinion in Hematology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Purpose of review This encompasses the recently published information on clonal hematopoiesis indeterminate potential (CHIP) and discusses its future prospects. By announcing advances in research CHIP risk factors related diseases, with purpose offering new insights to treat both hematologic nonhematologic disorders. Recent findings The majority studies have shown that is a common biological condition associated aging incidence increases age. pathophysiology blood diseases projected be significantly influenced by CHIP. Nevertheless, increasing expanded application cover such as cardiovascular, renal, liver, pulmonary diseases. Furthermore, fast advancement genetic testing technology preventive medicine, involvement variety disorders shows promise an essential target for preventing disease onset progression. Summary linked illnesses has significant influence individual's health outlook. Thus, identifying managing critical improving clinical results individuals concerned.

Language: Английский

Citations

0
Role of PARP Inhibitors: A New Hope for Breast Cancer Therapy DOI Open Access

K De,

Malabendu Jana,

Bhabadeb Chowdhury

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2773 - 2773

Published: March 19, 2025

Tumors formed by the unchecked growth of breast cells are known as cancer. The second most frequent cancer in world is It common among females. In 2022, 2,296,840 women were diagnosed with therapy evolving through development Poly (ADP-ribose) polymerase (PARP) inhibitors, which offering people specific genetic profiles new hope research into disease continues. focuses on patients BRCA1 and BRCA2 mutations. This review summarizes recent mechanisms action PARP inhibitors their implications for therapy. We how therapeutic applications developing highlight studies showing effectiveness these medicines whether used alone or combination. Furthermore, significance customized highlighted enhancing patient outcomes we address function testing identifying candidates inhibition. Recommendations future areas to maximize potential also included, along challenges limits clinical usage. objective this improve our comprehension complex interaction between biology knowledge will help guide screening approaches, practice, support preventive initiatives at risk.

Language: Английский

Citations

0
Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID) DOI Creative Commons

Attila Kállai,

Anna Ungvari,

Dóra Csabán

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Molecular and metabolic effects of chronic stress on health, aging and carcinogenesis DOI Open Access
G. V. Gerashchenko, M. A. Tukalo

Biopolymers and Cell, Journal Year: 2025, Volume and Issue: 41(1), P. 23 - 31

Published: April 14, 2025

Language: Английский

Citations

0
A novel label-free biosensor for myocardial ischemia biomarker detection via CRISPR/12a DOI

Chunping Liu,

Qiaojing Liu,

Xiaoling Chen

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 270, P. 116954 - 116954

Published: Nov. 17, 2024

Language: Английский

Citations

2