A Framework for an Effective Healthy Longevity Clinic DOI Creative Commons
Mironov Sp,

Olga Borysova,

Ivan Morgunov

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

In the context of an aging global population and imperative for innovative healthcare solutions, concept longevity clinics emerges as a timely vital area exploration. Unlike traditional medical facilities, offer unique approach to preclinical prevention, focusing on "prevention prevention" through utilization clocks biomarkers from healthy individuals. This article presents comprehensive overview clinics, encompassing descriptions existing models, development proposed framework, insights into biomarkers, wearable devices, therapeutic interventions. Additionally, economic justifications investing in are examined, highlighting significant growth potential biotechnology market its alignment with goals achieving active longevity. Anchored by Analytical Center, framework underscores importance data-driven decision-making innovation promoting prolonged enhanced human life. At present, there is no universally accepted standard model clinics. absence highlights need additional research ongoing improvements this field. Through synthesis scientific practical considerations, aims stimulate further discussion field ultimately contributing advancement practices aimed at extending enhancing

Language: Английский

Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases DOI Creative Commons
Anna Ungvari, Rafał Gulej, Roland Patai

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

Citations

3
Deep learning and generative artificial intelligence in aging research and healthy longevity medicine DOI Creative Commons
Dominika Wilczok

Aging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

With the global population aging at an unprecedented rate, there is a need to extend healthy productive life span. This review examines how Deep Learning (DL) and Generative Artificial Intelligence (GenAI) are used in biomarker discovery, deep clock development, geroprotector identification generation of dual-purpose therapeutics targeting disease. The paper explores emergence multimodal, multitasking research systems highlighting promising future directions for GenAI human animal research, as well clinical application longevity medicine.

Language: Английский

Citations

1
Mikhail ‘Misha’ Blagosklonny’s enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin DOI Creative Commons

David Barzilai

Aging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

The untimely passing of Dr. Mikhail "Misha" Blagosklonny has left a lasting void in geroscience and oncology. This review examines his profound contributions, focusing on pioneering the Hyperfunction Theory advocacy for rapamycin, an mTOR inhibitor, as therapeutic agent lifespan extension. Contrary to traditional damage-centric models, rejects damage accumulation primary driver aging. Instead, it redefines aging quasi-programmed process driven by persistent, excessive activity growth-promoting pathways beyond their developmental roles, leading age-related pathologies. We explore how Blagosklonny's insights predict rapamycin's ability decelerate modulating signaling, supported empirical evidence across multiple physiological systems, including immune, cardiovascular, cognitive, oncologic health. His forward-thinking approach, advocating cautious clinical use rapamycin suggesting personalized, preventive, combination therapy strategies, catalyzed interest translational geroscience. synthesizes legacy, presenting foundational pharmacological intervention with potential managing decline extending healthspan, underlines impact shifting research from theoretical frameworks actionable interventions. work remains enduring inspiration, paving way toward treating modifiable condition.

Language: Английский

Citations

0
From geroscience to precision geromedicine: Understanding and managing aging DOI
Guido Kroemer, Andrea B. Maier, Ana María Cuervo

et al.

Cell, Journal Year: 2025, Volume and Issue: 188(8), P. 2043 - 2062

Published: April 1, 2025

Language: Английский

Citations

0
Towards Precision Geromedicine in Singapore DOI Creative Commons

Jonas John Posko Amalaraj,

Louis Island,

Jane Yu Ying Ong

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0
Gerogenes and gerosuppression: the pillars of precision geromedicine DOI Creative Commons
Carlos López‐Otín, Andrea B. Maier, Guido Kroemer

et al.

Cell Research, Journal Year: 2024, Volume and Issue: 34(7), P. 463 - 466

Published: May 27, 2024

Language: Английский

Citations

3
A Framework for an Effective Healthy Longevity Clinic DOI Creative Commons
Mironov Sp,

Olga Borysova,

Ivan Morgunov

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

In the context of an aging global population and imperative for innovative healthcare solutions, concept longevity clinics emerges as a timely vital area exploration. Unlike traditional medical facilities, offer unique approach to preclinical prevention, focusing on "prevention prevention" through utilization clocks biomarkers from healthy individuals. This article presents comprehensive overview clinics, encompassing descriptions existing models, development proposed framework, insights into biomarkers, wearable devices, therapeutic interventions. Additionally, economic justifications investing in are examined, highlighting significant growth potential biotechnology market its alignment with goals achieving active longevity. Anchored by Analytical Center, framework underscores importance data-driven decision-making innovation promoting prolonged enhanced human life. At present, there is no universally accepted standard model clinics. absence highlights need additional research ongoing improvements this field. Through synthesis scientific practical considerations, aims stimulate further discussion field ultimately contributing advancement practices aimed at extending enhancing

Language: Английский

Citations

1