Pharmacology of Aging: Drosophila as a Tool to Validate Drug Targets for Healthy Lifespan DOI
Helena M. Cochemé, Eliano dos Santos

Published: Sept. 13, 2024

Finding effective therapies to manage age-related conditions is an emerging public health challenge. Although disease-targeted treatments are important, a preventive approach focused on aging can be more efficient. Pharmacological targeting of aging-related processes extend lifespan and improve in animal models. However, drug development translation particularly challenging geroscience. Preclinical studies have survival as major endpoint for screening, which requires years research mammalian Shorter-lived invertebrates exploited accelerate this process. In particular, the fruit fly

Language: Английский

Thioredoxin System in Insects: Uncovering the Roles of Thioredoxins and Thioredoxin Reductase beyond the Antioxidant Defences DOI Creative Commons

Andrea Gřešková,

Marek Petřivalský

Insects, Journal Year: 2024, Volume and Issue: 15(10), P. 797 - 797

Published: Oct. 14, 2024

Increased levels of reactive oxygen species (ROS) produced during aerobic metabolism in animals can negatively affect the intracellular redox status, cause oxidative stress and interfere with physiological processes cells. The antioxidant defence regulates ROS by interplaying diverse enzymes non-enzymatic metabolites. thioredoxin system, consisting enzyme reductase (TrxR), redox-active protein (Trx) NADPH, represent a crucial component defence. It is involved signalling regulation multiple developmental processes, such as cell proliferation or apoptotic death. Insects have evolved unique variations TrxR, which resemble mammalian overall structure catalytic mechanisms, but selenocysteine-cysteine pair active site replaced cysteine-cysteine typical bacteria. Moreover, role system insects indispensable due to absence glutathione reductase, an essential system. However, functions Trx are still poorly characterised. In present review, we provide critical overview current knowledge on insect focusing mainly TrxR's immune model species.

Language: Английский

Citations

4
Studying Cellular Senescence Using the Model Organism Drosophila melanogaster DOI

Xanthippi P. Louka,

Sentiljana Gumeni, Ioannis P. Trougakos

et al.

Methods in molecular biology, Journal Year: 2025, Volume and Issue: unknown, P. 281 - 299

Published: Jan. 1, 2025

Language: Английский

Citations

0
Pharmacology of Aging: Drosophila as a Tool to Validate Drug Targets for Healthy Lifespan DOI
Helena M. Cochemé, Eliano dos Santos

Published: Sept. 13, 2024

Finding effective therapies to manage age-related conditions is an emerging public health challenge. Although disease-targeted treatments are important, a preventive approach focused on aging can be more efficient. Pharmacological targeting of aging-related processes extend lifespan and improve in animal models. However, drug development translation particularly challenging geroscience. Preclinical studies have survival as major endpoint for screening, which requires years research mammalian Shorter-lived invertebrates exploited accelerate this process. In particular, the fruit fly

Language: Английский

Citations

0