Emerging therapeutic strategies to mitigate female and male reproductive aging

Nature Aging, Journal Year: 2024, Volume and Issue: 4(12), P. 1682 - 1696

Published: Dec. 13, 2024

Language: Английский

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Ovarian Mechanobiology: Understanding the Interplay Between Mechanics and Follicular Development

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 355 - 355

Published: Feb. 28, 2025

The ovary is a dynamic organ where mechanical forces profoundly regulate follicular development, oocyte maturation, and overall reproductive function. These forces, originating from the extracellular matrix (ECM), granulosa theca cells, ovarian stroma, influence cellular behavior through mechanotransduction, translating stimuli into biochemical responses. This review explores intricate interplay between cues biology, focusing on key mechanosensitive pathways such as Hippo signaling, PI3K/AKT pathway, cytoskeletal remodeling, which govern dormancy, activation, growth. Additionally, it examines how aging disrupts microenvironment, with ECM stiffening altered mechanotransduction contributing to decline in reserve potential. Emerging technologies, including 3D culture systems organ-on-chip platforms, are highlighted for their ability replicate microenvironment advance drug discovery therapeutic interventions. By integrating mechanobiological principles, this aims enhance our understanding of function provide new strategies preserving fertility combating infertility.

Language: Английский

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Modeling the extension of ovarian function after therapeutic targeting of the primordial follicle reserve

Human Reproduction Update, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract BACKGROUND Women are increasingly choosing to delay childbirth, and those with low ovarian reserves indicative of primary insufficiency at risk for sub- infertility also the early onset menopause. Experimental strategies that promise extend duration function in women currently being developed. One strategy is slow rate loss existing primordial follicles (PFs), a second increase, or ‘boost’, number autologous PFs human ovary. In both cases, would be expected lengthened, menopause delayed. This might accompanied by an extended production mature oocytes sufficient quality fertile lifespan. OBJECTIVE AND RATIONALE this work, we consider how slowing physiological aging improve health well-being patients, summarize current state-of-the-art approaches We then use mathematical modeling determine interventions likely influence quantitatively. Finally, efficacy benchmarks should achieved so individuals will benefit, propose criteria could used monitor ongoing different patients as these validated. SEARCH METHODS Current methods estimate size reserve its relationship timing menopausal transition were compiled, publications establishing designed deliver additional identified. OUTCOMES review our understanding consequences reproductive women, compare may POI. provide decay presence therapies PF boost numbers. An interactive online tool provided estimates impact across natural population. Modeling output shows treatments need applied possible many years achieve significant contrast, add occur late relative Combined while boosting numbers (new) offer some benefits delaying WIDER IMPLICATIONS Extending function, perhaps lifespan, on horizon least patients. without such complements helps guide clinical goal. REGISTRATION NUMBER Not applicable.

Language: Английский

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Hallmarks of female reproductive aging in physiologic aging mice

Nature Aging, Journal Year: 2024, Volume and Issue: 4(12), P. 1711 - 1730

Published: Dec. 13, 2024

Language: Английский

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