International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2938 - 2938
Published: March 2, 2024
Poly(propylene
carbonate)
(PPC)
is
an
emerging
“carbon
fixation”
polymer
that
holds
the
potential
to
become
a
“biomaterial
of
choice”
in
healthcare
owing
its
good
biocompatibility,
tunable
biodegradability
and
safe
degradation
products.
However,
commercialization
wide
application
PPC
as
biomedical
material
are
still
hindered
by
narrow
processing
temperature
range,
poor
mechanical
properties
hydrophobic
nature.
Over
recent
decades,
several
physical,
chemical
biological
modifications
have
been
achieved
introducing
biocompatible
polymers,
inorganic
ions
or
small
molecules,
which
can
endow
with
better
cytocompatibility
desirable
biodegradability,
thus
enable
various
applications.
Indeed,
variety
PPC-based
degradable
materials
used
medical
applications
including
masks,
surgical
gowns,
drug
carriers,
wound
dressings,
implants
scaffolds.
In
this
review,
molecular
structure,
catalysts
for
synthesis,
discussed.
Recent
biomaterials
highlighted
summarized.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(22)
Published: March 14, 2023
Cuproptosis
is
a
new
cell
death
that
depends
on
copper
(Cu)
ionophores
to
transport
Cu
into
cancer
cells,
which
induces
death.
However,
existing
are
small
molecules
with
short
blood
half-life
making
it
hard
enough
cells.
Herein,
reactive
oxygen
species
(ROS)-sensitive
polymer
(PHPM)
designed,
used
co-encapsulate
elesclomol
(ES)
and
form
nanoparticles
(NP@ESCu).
After
entering
ES
Cu,
triggered
by
excessive
intracellular
ROS,
readily
released.
work
in
concerted
way
not
only
kill
cells
cuproptosis,
but
also
induce
immune
responses.
In
vitro,
the
ability
of
NP@ESCu
efficiently
cuproptosis
investigated.
addition,
change
transcriptomes
treated
explored
RNA-Seq.
vivo,
found
mice
model
subcutaneous
bladder
cancer,
reprograming
tumor
microenvironment.
Additionally,
further
combined
anti-programmed
protein
ligand-1
antibody
(αPD-L1).
This
study
provides
first
report
combining
nanomedicine
can
αPD-L1
for
enhanced
therapy,
thereby
providing
novel
strategy
future
therapy.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(3), P. 1879 - 1905
Published: Jan. 30, 2023
Covalent
organic
frameworks
(COFs)
are
a
type
of
crystalline
porous
material
with
specific
features
and
interesting
structures,
including
porosity,
large
surface
area,
biocompatibility.
These
enable
COFs
to
be
considered
as
excellent
candidates
for
applications
in
various
fields.
Recently,
have
been
widely
demonstrated
promising
materials
biomedical
because
their
physicochemical
properties
ultrathin
structures.
In
this
review,
we
cover
the
recent
progress
COF
photodynamic
therapy,
gene
delivery,
photothermal
drug
bioimaging,
biosensing,
combined
therapies.
Moreover,
critical
challenges
further
perspectives
regards
future
biology-facing
also
discussed.
ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(15), P. 9307 - 9324
Published: July 18, 2022
Plastic
waste
triggers
a
series
of
concerns
because
its
disruptive
impact
on
the
environment
and
ecosystem.
From
point
view
catalysis,
however,
end-of-life
plastics
can
be
seen
as
an
untapped
feedstock
for
preparation
value-added
products.
Thus,
development
diversified
catalytic
approaches
valorization
is
urgent.
Previous
reviews
this
field
have
systematically
summarized
progress
made
plastic
reclamation.
In
review,
we
emphasize
design
processes
by
leveraging
state-of-the-art
technologies
from
other
developed
fields
to
derive
valuable
polymers,
functional
materials,
chemicals
plastics.
The
principles,
mechanisms,
opportunities
chemical
(thermo-,
electro-,
photocatalytic)
well
biocatalytic
ones
are
discussed,
which
may
provide
more
insights
future
processes.
Finally,
outlooks
perspectives
accelerate
toward
feasible
economy
discussed.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
19, P. 550 - 568
Published: May 9, 2022
Spinal
cord
injury
(SCI)
is
an
overwhelming
and
incurable
disabling
event
accompanied
by
complicated
inflammation-related
pathological
processes,
such
as
excessive
reactive
oxygen
species
(ROS)
produced
the
infiltrated
inflammatory
immune
cells
released
to
extracellular
microenvironment,
leading
widespread
apoptosis
of
neuron
cells,
glial
oligodendroctyes.
In
this
study,
a
thioketal-containing
ROS-scavenging
hydrogel
was
prepared
for
encapsulation
bone
marrow
derived
mesenchymal
stem
(BMSCs),
which
promoted
neurogenesis
axon
regeneration
scavenging
overproduced
ROS
re-building
regenerative
microenvironment.
The
could
effectively
encapsulate
BMSCs,
played
remarkable
neuroprotective
role
in
vivo
reducing
production
endogenous
ROS,
attenuating
ROS-mediated
oxidative
damage
downregulating
cytokines
interleukin-1
beta
(IL-1β),
interleukin-6
(IL-6)
tumor
necrosis
factor-alpha
(TNF-α),
resulting
reduced
cell
spinal
tissue.
BMSCs-encapsulated
also
scar
formation,
improved
tissue,
thus
distinctly
enhanced
motor
functional
recovery
SCI
rats.
Our
work
provides
combinational
strategy
against
stress,
with
potential
applications
not
only
SCI,
but
other
central
nervous
system
diseases
similar
conditions.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Oct. 21, 2022
Abstract
Diabetic
wound
is
one
of
the
most
intractable
chronic
wounds
that
prone
to
bacterial
infection.
Hypoxia
an
important
feature
in
its
microenvironment.
However,
it
challenging
for
antimicrobial
therapy
directly
apply
existing
hypoxia-responsive
drug
delivery
systems
due
active
targeting
deficiency
and
biofilm
obstacle.
Herein,
we
customizes
a
carrier,
lactose-modified
azocalix[4]arene
(LacAC4A)
with
ability
actively
target
inhibit
biofilm.
By
loading
ciprofloxacin
(Cip),
resultant
supramolecular
nanoformulation
Cip@LacAC4A
demonstrates
enhanced
antibacterial
efficacy
resulting
from
both
increased
accumulation
controlled
release
at
site
When
applied
on
diabetic
together
multidrug-resistant
Pseudomonas
aeruginosa
infection
vivo,
induces
definitely
less
inflammatory
infiltration
than
free
Cip,
which
translates
into
high
healing
performance.
Importantly,
such
design
principle
provides
direction
developing
systems.
Gels,
Journal Year:
2024,
Volume and Issue:
10(1), P. 43 - 43
Published: Jan. 5, 2024
The
care
and
rehabilitation
of
acute
chronic
wounds
have
a
significant
social
economic
impact
on
patients
global
health.
This
burden
is
primarily
due
to
the
adverse
effects
infections,
prolonged
recovery,
associated
treatment
costs.
Chronic
can
be
treated
with
variety
approaches,
which
include
surgery,
negative
pressure
wound
therapy,
dressings,
hyperbaric
oxygen
therapy.
However,
each
these
strategies
has
an
array
limitations.
existing
dry
dressings
lack
functionality
in
promoting
healing
exacerbating
pain
by
adhering
wound.
Hydrogels,
are
commonly
polymer-based
swell
water,
been
proposed
as
potential
remedies
their
ability
provide
moist
environment
that
facilitates
healing.
Their
unique
composition
enables
them
absorb
exudates,
exhibit
shape
adaptability,
modified
incorporate
active
compounds
such
growth
factors
antibacterial
compounds.
review
provides
updated
discussion
leading
natural
synthetic
hydrogels
utilized
healing,
details
latest
advancements
hydrogel
technology,
explores
alternate
approaches
this
field.
Search
engines
Scopus,
PubMed,
Science
Direct,
Web
were
advances
applications
over
last
fifteen
years.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(21)
Published: Feb. 10, 2024
Abstract
Immunotherapy
has
received
widespread
attention
for
its
effective
and
long‐term
tumor‐eliminating
ability.
However,
immunogenic
“cold”
tumors,
such
as
prostate
cancer
(PCa),
the
low
immunogenicity
of
tumor
itself
is
a
serious
obstacle
to
efficacy.
Here,
this
work
reports
strategy
enhance
PCa
by
triggering
cascade
self‐enhanced
ferroptosis
in
cells,
turning
from
“hot”.
This
develops
transformable
self‐assembled
peptide
TEP‐FFG‐CRApY
with
alkaline
phosphatase
(ALP)
responsiveness
glutathione
peroxidase
4
(GPX4)
protein
targeting.
self‐assembles
into
nanoparticles
under
aqueous
conditions
transforms
nanofibers
response
ALP
during
endosome/lysosome
uptake
promoting
lysosomal
membrane
permeabilization
(LMP).
On
one
hand,
released
TEP‐FFG‐CRAY
target
GPX4
selectively
degrade
light
irradiation,
inducing
ferroptosis;
on
other
large
amount
leaked
Fe
2+
further
amplify
through
Fenton
reaction.
TEP‐FFG‐CRApY‐induced
improves
cell
maturation
dendritic
cells
(DCs)
increasing
intratumor
T‐cell
infiltration.
More
importantly,
recovered
T
secreting
amounts
interferon‐gamma
(IFN‐γ).
provides
novel
molecular
design
synergistic
molecularly
targeted
therapy
tumors.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(18)
Published: March 26, 2024
Cuproptosis
is
dependent
on
mitochondrial
respiration
modulation
by
targeting
lipoylated
tricarboxylic
acid
cycle
(TCA)
proteins,
showing
great
potential
in
cancer
treatment.
However,
the
specific
release
of
copper
ions
at
highly
needed
and
still
a
major
challenge
to
trigger
cellular
cuproptosis.
Herein,
metal-organic
framework-based
nanoplatform
(ZCProP)
designed
for
mitochondrial-targeted
ATP/pH-responsive
Cu
