Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 139925 - 139925
Published: Sept. 4, 2024
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 516, P. 215990 - 215990
Published: May 31, 2024
Language: Английский
Citations
53
Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(1)
Published: Jan. 9, 2025
Language: Английский
Citations
2
Industrial & Engineering Chemistry Research, Journal Year: 2025, Volume and Issue: 64(4), P. 1907 - 1932
Published: Jan. 14, 2025
Metal–organic frameworks (MOFs) have been shown to be great alternatives traditional porous materials in various chemical applications, and they very widely studied for biomedical applications the past decade specifically drug storage. After our review published 2011 [Keskin Kızılel, Ind. Eng. Chem. Res. 2011, 50 (4), 1799–1812, 10.1021/ie101312k], we witnessed a fast growth not only number variety of MOFs but also their usage across broad spectrum fields. With recent integration molecular modeling data science approaches experimental studies, significantly accelerated positioning them as pivotal components regenerative medicine, medical imaging, diagnostics. In this review, visited diverse considering computational efforts on storage delivery, bioimaging, biosensing. We focused underlying mechanisms governing interactions between biological systems discussed both opportunities challenges field highlight potential advanced therapeutics cancer neurological diseases.
Language: Английский
Citations
1
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Cancer poses a substantial threat and serious challenge to public human health, driving the promotion of sophisticated technologies for cancer therapy. While conventional chemotherapy has bottlenecks such as low delivery efficiency, strong toxic side effects, tumor enrichment barriers, magnetic micro/nanorobots (MNRs) emerge promising therapeutic candidates that provide alternative strategies MNR is kind human-made machine micro- or nanosized, reasonably designed, performs command tasks through self-actuated externally controlled propulsion mechanisms, which can be potentially applied in theranostics. Here, this review first introduces components constitute typical MNR, including body part, control function sensing part. Subsequently, elucidates representative fabrication methods construct MNRs from top-down approaches bottom-up approaches, covering injection molding, self-rolling, melt electrospinning writing, deposition, biotemplate method, lithography, assembling, 3D printing, chemical synthesis. Furthermore, focuses on multiple applications facing diagnosis treatment, encompassing imaging, quantification, drug release, synergy with therapies, cell manipulation, surgical assistance. Then, systematically elaborates biocompatibility biosafety MNRs. Finally, challenges faced by are discussed alongside future research directions. This intended scientific guidance may improve comprehension cognition theranostics platform MNRs, promoting prospering practical application development
Language: Английский
Citations
1
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(28)
Published: April 25, 2024
Abstract Light‐driven micro/nanorobots (LMNRs) are tiny, untethered machines with great potential in fields like precision medicine, nano manufacturing, and various other domains. However, their practicality hinges on developing light‐manipulation strategies that combine versatile functionalities, flexible design options, precise controllability. Our study introduces an innovative approach to construct (MNRs) by utilizing micro/nanomotors as fundamental building blocks. Inspired silicon Metal‐Insulator‐Semiconductor (MIS) solar cell principles, we a new type of optomagnetic hybrid micromotors (OHMs). These OHMs have been skillfully optimized integrated magnetic constituent, resulting efficient light propulsion, navigation, the for controlled assembly. One key features is ability exhibit diverse motion modes influenced fracture surfaces interactions environment, streamlining cargo conveyance along “micro expressway”—the predesigned microchannels. Further enhancing versatility, template‐guided assembly strategy facilitates these into functional microrobots, encompassing configurations such “V‐shaped”, “N‐shaped”, 3D structured microrobots. The heightened capabilities underscore inherent micromotor assembly, which provides foundational platform realization multi‐component work moves step toward forthcoming microrobotic entities boasting advanced functionalities.
Language: Английский
Citations
5
International Journal of Extreme Manufacturing, Journal Year: 2024, Volume and Issue: 6(6), P. 062006 - 062006
Published: Aug. 21, 2024
Abstract Micro/nanorobots (MNRs) capable of performing tasks at the micro- and nanoscale hold great promise for applications in cutting-edge fields such as biomedical engineering, environmental microfabrication. To cope with intricate dynamic environments encountered practical applications, development high performance MNRs is crucial. They have evolved from single-material, single-function, simple structure to multi-material, multi-function, complex structure. However, design manufacturing multi-material three-dimensional structures pose significant challenges that cannot be addressed by conventional serial strategies single-process methods. The material-interface-structure-function/ coupled methods additive/formative/subtractive composite offer opportunity manufacture multi-materials under multi-factor coupling, thus paving way MNRs. In this paper, we take three core capabilities MNRs—mobility, controllability, load capability—as focal point, emphasizing oriented towards their function/performance functional structures. limitations current investigation are also discussed, our envisioned future directions shared. We hope review will provide a framework template MNRs, serving roadmap researchers interested area.
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)
Published: June 21, 2024
Emerging light-driven micro/nanorobots (LMNRs) showcase profound potential for sophisticated manipulation and various applications. However, the realization of a versatile straightforward fabrication technique remains challenging pursuit. This study introduces an innovative bulk heterojunction organic semiconductor solar cell (OSC)-based spin-coating approach, aiming to facilitate arbitrary construction LMNRs. Leveraging distinctive properties near-infrared (NIR)-responsive solution, this enables uniform coating across dimensional structures (0D, 1D, 2D, 3D) be LMNRs, denoted as "motorization." The film, with slender profile measuring ≈140 nm in thickness, effectively preserves original morphology objects while imparting actuation capabilities exceeding hundreds times their own weight. propelled motion these microrobots is realized through NIR-driven photoelectrochemical reaction-induced self-diffusiophoresis, showcasing array controllable profiles. strategic customization microrobot addresses specific applications, ranging from 0D inducing living crystal formation intricate, multidimensional designed tasks such microplastic extraction, cargo delivery, phototactic precise maneuvers. advances user-friendly LMNR technologies, unlocking new possibilities signaling transformative era multifunctional micro/nanorobot technologies.
Language: Английский
Citations
4
RSC Advances, Journal Year: 2024, Volume and Issue: 14(29), P. 20799 - 20808
Published: Jan. 1, 2024
Nanoscale covalent organic frameworks (NCOFs) as emerging drug-delivery nanocarriers have received much attention in biomedicine recent years. However, there are few reports on the application of pH-responsive NCOFs for drug delivery nanosystems. In this work, hydrazone-decorated pH-triggered molecular switches designed efficient cancer therapy. These functionalized with hydrazone groups channel walls (named NCOFs-NHNH2) obtained via a post-synthetic modification strategy. Subsequently, anticancer doxorubicin (DOX) model molecule is loaded through linkage to yield NCOFs-NN-DOX. Finally, soybean phospholipid (SP) coated surface HNTs-NN-DOX, named NCOFs-NN-DOX@SP, further enhance dispersibility, stability and biocompatibility HNTs physiological solution. NCOFs-NN-DOX@SP showed an excellent intelligent sustained-release effect almost sixfold increase at pH = 5.2 than 7.4. vitro cell toxicity imaging assays exhibited enhanced therapeutic Lewis lung carcinoma (LLC) cells, demonstrating that fabricated great potential Thus, work provides new way toward designing stimulus-responsive promotes their on-demand system field treatment.
Language: Английский
Citations
4
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(34), P. 8235 - 8266
Published: Jan. 1, 2024
Various stimuli-responsive MOFs require different triggers and exhibit diverse applications, necessitating the development of biomedical application strategies tailored to specific environments.
Language: Английский
Citations
4
Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Language: Английский
Citations
0