Archives of Physiology and Biochemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 13
Published: Nov. 11, 2024
The
introduction
of
Tyrosine
Kinase
Inhibitors
(TKIs)
has
revolutionised
cancer
treatment,
yet
concerns
regarding
cardiovascular
toxicity
have
surfaced.
This
piece
delves
into
the
interplay
between
AMP-activated
protein
kinase
(AMPK)
signalling
and
TKI-induced
toxicity.
study
unravels
intricate
relationship
AMPK
activation
toxicity,
aiming
to
ascertain
whether
can
play
a
strategic
role
in
mitigating
adverse
effects.
Beyond
unravelling
mechanistic
insights,
research
sets
stage
for
future
therapeutic
approaches,
envisioning
as
pivotal
connection
balancing
effective
treatment
with
well-being.
As
advances,
potential
not
only
addresses
challenges
but
also
shapes
landscape
personalised
anticancer
therapies.
article
explores
mechanisms
AMPK's
impact
on
health,
implications
alleviating
TKI-associated
toxicities.
Green Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
We
have
developed
a
mild
and
efficient
electrochemical
reduction
approach
employing
aryl
diazonium
salts
as
dual
synthons
to
synthesize
valuable
multi-substituted
pyrazoles
for
the
first
time.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
paper
reviews
progress
in
the
photochemical/electrochemical
construction
of
heterocyclic
compounds
using
CO
2
,
differentiating
between
various
reaction
types
and
elucidating
their
underlying
mechanisms
as
well
potential
applications.
Green Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
An
electrochemical
method
for
selenylating
tetrahydroquinolines
with
diselenides
is
presented.
By
tuning
reaction
conditions,
C-3
selenylated
quinolines
and
C-6
can
be
selectively
synthesized
excellent
outcomes.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Vinyl
sulfonates
are
vital
intermediates
in
organic
synthesis,
serving
as
versatile
electrophiles
various
cross-coupling
reactions.
Despite
their
significance,
direct
methods
for
synthesizing
vinyl
from
styrenes
have
been
limited.
In
this
study,
we
introduce
an
innovative
electrochemical
approach
that
leverages
bromine
radical
mediation
to
facilitate
the
synthesis
of
sulfonates,
cheap
nBu4NBr
acts
both
electrolyte
and
a
catalytic
amount.
This
process
involves
reaction
with
sodium
sulfinates
water
under
conditions,
offering
straightforward
pathway
these
compounds.
The
developed
strategy
is
characterized
by
its
high
efficiency,
operational
simplicity,
environmentally
benign
nature,
adhering
principles
green
chemistry
while
ensuring
atom
economy
remarkable
regioselectivity.
Furthermore,
methodology
proves
effective
gram-scale
allows
subsequent
functionalization
sulfonate
products
pharmaceutical
derivatives,
thus
broadening
potential
applications
techniques
styrene
functionalization.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
Organoselenium
compounds
and
quinolines
are
widely
used
in
drugs
materials.
Herein,
we
report
an
electro-oxidative
cyclization
between
isocyanides
diselenides
to
effectively
synthesize
2-organoselenyl
a
simple
undivided
cell
without
transition-metal
catalysts
or
toxic
oxidants.
Gram-scale
synthesis
postsynthetic
modifications
highlighted
the
practicality
of
this
electrochemical
strategy.
A
series
produced
with
up
82%
yield,
good
functional
group
tolerance
high
atom
efficiency
under
room
temperature.
Journal of Nutrition and Metabolism,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Background:
This
systematic
review
aimed
to
assess
the
association
of
iron
level
with
gestational
diabetes
mellitus
(GDM)
risk.
Methods:
The
relevant
articles
published
between
January
1,
1995
and
17,
2023
were
identified
through
a
literature
search.
study
used
random
effects
summarize
relative
risks
(RRs)
95%
confidence
intervals
(CIs)
GDM
risk
standardized
mean
differences.
investigated
ferritin
exposure
combined
dose-response
analysis
explored
both
linear
nonlinear
trends.
Results:
meta-analysis
selected
30
studies
serum
(SF),
18
(SI),
4
transferrin
receptor
(sTfR),
5
total
binding
capacity
(TIBC),
(TRF).
summarized
RRs
comparing
persons
highest
concentration
categories
SF
lowest
an
unadjusted
odds
ratio
2.05
(1.67-2.53;
I
2
=
62.8%,
p
<
0.001,
z
6.76,
0.001)
adjusted
1.82
(1.54-2.14;
12.9%,
p=0.312,
7.21,
0.001).
Linear
showed
that
increase
in
μg/L
increased
by
2.66%
(1.026
[95%
CI:
1.017,
1.036],
n
5).
relationship
also
indicates
is
consistently
associated
increasing
GDM.
Conclusion:
High
ferritin,
high
levels,
low
TIBC
are
