The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis DOI Creative Commons
Ting Shen,

Yumei Yue,

Tingting He

et al.

Frontiers in Aging Neuroscience, Journal Year: 2021, Volume and Issue: 13

Published: Feb. 12, 2021

Patients with Parkinson's disease (PD) were often observed gastrointestinal symptoms, which preceded the onset of motor symptoms. Neuropathology PD has also been found in enteric nervous system (ENS). Many studies have reported significant PD-related alterations gut microbiota. This meta-analysis was performed to evaluate differences microbiota between patients and healthy controls (HCs) across different geographical regions. We conducted a systematic online search for case-control detecting HCs. Mean difference (MD) 95% confidence interval (CI) calculated access abundance certain families PD. Fifteen included this study. Our results showed lower levels Prevotellaceae (MD = −0.37, CI −0.62 −0.11), Faecalibacterium −0.41, CI: −0.57 −0.24), Lachnospiraceae −0.34, −0.59 −0.09) compared Significant higher level Bifidobacteriaceae 0.38, 95%; 0.12 0.63), Ruminococcaceae 0.58, 0.07 1.10), Verrucomicrobiaceae 0.45, 0.21 0.69), Christensenellaceae 0.20, 0.34) Thus, shared detected These dysbiosis might lead impairment short-chain fatty acids (SCFAs) producing process, lipid metabolism, immunoregulatory function, intestinal permeability, contribute pathogenesis

Language: Английский

Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease DOI Open Access
Hiroshi Nishiwaki, Mikako Ito,

Tomohiro Ishida

et al.

Movement Disorders, Journal Year: 2020, Volume and Issue: 35(9), P. 1626 - 1635

Published: June 18, 2020

Abstract Background PD may begin with the intestinal accumulation of α‐synuclein fibrils, which can be causally associated gut dysbiosis. The variability microbiota across countries prevented us from identifying shared dysbiosis in PD. Objectives To identify countries. Methods We performed 16S ribosomal RNA gene sequencing analysis 223 patients and 137 controls, meta‐analyzed by combining our dataset four previously reported data sets United States, Finland, Russia, Germany. excluded uncommon taxa analyses. For pathway analysis, we developed Kyoto Encyclopedia Genes Genomes orthology set enrichment method. Results After adjusting for confounding factors (body mass index, constipation, sex, age, catechol‐O‐methyl transferase inhibitor), genera Akkermansia Catabacter , as well families Akkermansiaceae were increased, whereas Roseburia Faecalibacterium Lachnospiraceae ND3007 group decreased Catechol‐O‐methyl inhibitor intake markedly increased family Lactobacillaceae . Inspection these bacteria 12 datasets that not included meta‐analysis revealed genus frequently observed changes short‐chain fatty acid metabolisms dataset. Conclusions report mucin layer‐degrading is acid–producing are © 2020 International Parkinson Movement Disorder Society

Language: Английский

Citations

278
Role of microbiota-derived short-chain fatty acids in nervous system disorders DOI Open Access
Rasoul Mirzaei, Behnaz Bouzari, Seyed Reza Hosseini‐Fard

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 139, P. 111661 - 111661

Published: May 8, 2021

During the past decade, accumulating evidence from research highlights suggested effects of bacterial communities human gut microbiota and their metabolites on health disease. In this regard, microbiota-derived receptors, beyond immune system, maintain metabolism homeostasis, which is essential to host's by balancing utilization intake nutrients. It has been shown that dysbiosis can cause pathology altered metabolites' formation, resulting in dysregulation system metabolism. The short-chain fatty acids (SCFAs), such as butyrate, acetate, succinate, are produced due fermentation process bacteria gut. noted remodeling associated with pathophysiology several neurological disorders, Alzheimer's disease, multiple sclerosis, Parkinson's amyotrophic lateral stress, anxiety, depression, autism, vascular dementia, schizophrenia, stroke, neuromyelitis optica spectrum among others. This review will discuss current most significant studies dealing some SCFAs microbial selected disorders.

Language: Английский

Citations

271
Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases DOI Open Access

Sara Gerhardt,

M. Hasan Mohajeri

Nutrients, Journal Year: 2018, Volume and Issue: 10(6), P. 708 - 708

Published: June 1, 2018

In recent years evidence has emerged that neurodegenerative diseases (NDs) are strongly associated with the microbiome composition in gut. Parkinson’s disease (PD) is most intensively studied this context. review, we performed a systematic evaluation of published literature comparing changes colonic PD to ones observed other NDs including Alzheimer’s (AD), multiple system atrophy (MSA), sclerosis (MS), neuromyelitis optica (NMO) and amyotrophic lateral (ALS). To enhance comparability different studies, only human case-control studies were included. Several showed an increase Lactobacillus, Bifidobacterium, Verrucomicrobiaceae Akkermansia PD. A decrease Faecalibacterium spp., Coprococcus Blautia Prevotella spp. Prevotellaceae was On low taxonomic resolution, like phylum level, not disease-specific inconsistent. However, on higher resolution genus or species minor overlap between MSA, both alpha synucleinopathies. We show standardization sample collection analysis necessary for ensuring reproducibility data. also provide assessing microbiota at high reveals relative abundance may be specific characteristic one group, might evolve discriminative power. The interactions bacterial strains co-abundances must investigated before assumptions about effects bacteria host can made certainty.

Language: Английский

Citations

264
Gut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis DOI Creative Commons
Shan Liang, Xiaoli Wu, Feng Jin

et al.

Frontiers in Integrative Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: Sept. 11, 2018

Mental disorders and neurological diseases have brought rapidly increasing medical burdens. Although extensive researches been conducted hugely, effective therapies still progressing slowly. Current dilemma reminds us that the human is a superorganism. Only if we take self its partner microbiota into consideration at same time can better understand these diseases. Over last few centuries, has experienced tremendous changes much more than own genes because of modern transformations in diet, lifestyle, care, so on, paralleling epidemiological transition. Existing research indicates gut plays an important role this According to gut–brain psychology, crucial part gut–brain, it communicates with brain via microbiota–gut–brain axis. The almost develops synchronously brain, mind. Gut influences various normal mental processes phenomena they are involved pathophysiology numerous Targeting therapy for promising approach supported by three theories: hypothesis, "old friend" leaky theory. effects behavior fulfilled through microbiota-gut-brain axis which mainly composed nervous pathway, endocrine immune pathway. Undoubtedly, psychology will bring great enhancement neuroscience, psychiatry. Various improving methods including FMT, probiotics, prebiotics, healthy lifestyle shown capability promote function brain. Harnessing improve health, prevent related be true future.

Language: Английский

Citations

235
Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study DOI Creative Commons

Tomomi Minato,

Tetsuya Maeda,

Yoshiro Fujisawa

et al.

PLoS ONE, Journal Year: 2017, Volume and Issue: 12(11), P. e0187307 - e0187307

Published: Nov. 1, 2017

Background We previously reported gut dysbiosis in patients with Parkinson’s disease (PD). Objective The aim of this study is to examine whether correlates the progression PD. Methods examined changes microbiota and demographic features 2 years 36 PD patients. Results A change total UPDRS scores was predicted by counts Bifidobacterium Atopobium cluster at year 0 a correlation coefficient 0.52. Correlation analysis additionally revealed that low Bacteroides fragilis were associated worsening I years. In addition, hallucinations/delusions Similarly, B. motivation/initiative evenly divided into deteriorated stable groups based on degree scores. group had lower Bifidobacterium, fragilis, Clostridium leptium than but not 2, suggesting may demonstrate accelerated lowering these bacteria 0. Conclusions intestinal bacterial decrease course progression. Temporal profiles are likely be different from bacteria, also between deteriorating groups, which able exploited differentiate rapidly slowly progressive pathology.

Language: Английский

Citations

234
Gut Microbiota and Metabolome Alterations Associated with Parkinson’s Disease DOI Creative Commons
Sarah Vascellari, Vanessa Palmas, Marta Melis

et al.

mSystems, Journal Year: 2020, Volume and Issue: 5(5)

Published: Sept. 14, 2020

Parkinson's disease is a neurodegenerative disorder characterized by the accumulation of intracellular aggregates misfolded alpha-synuclein along cerebral axis. Several studies report association between intestinal dysbiosis and disease, although cause-effect relationship remains to be established. Herein, gut microbiota composition 64 Italian patients with 51 controls was determined using next-generation sequencing approach. A real metagenomics shape based on gas chromatography-mass spectrometry also investigated. The most significant changes within group highlighted reduction in bacterial taxa, which are linked anti-inflammatory/neuroprotective effects, particularly Lachnospiraceae family key members, such as Butyrivibrio, Pseudobutyrivibrio, Coprococcus, Blautia direct evaluation fecal metabolites revealed several classes metabolites. Changes were seen lipids (linoleic acid, oleic succinic sebacic acid), vitamins (pantothenic acid nicotinic amino acids (isoleucine, leucine, phenylalanine, glutamic pyroglutamic acid) other organic compounds (cadaverine, ethanolamine, hydroxy propionic acid). Most modified strongly correlated abundance members belonging family, suggesting that these bacteria correlate altered metabolism rates disease.IMPORTANCE To our knowledge, this one few thus far correlates analysis disease. Overall, data highlight modifications numerous This suggests associated dysregulation involves synergistic microbes favoring homeostasis. Interestingly, short-chain fatty (SCFA)-producing influenced metabolomics profile, affecting potential protective effects Parkinson group. On hand, extensive impact has at level metabolic pathways could encourage identification specific biomarkers for diagnosis treatment light effect drugs have microbiota.

Language: Английский

Citations

230
Gut microbiota in patients with Parkinson's disease in southern China DOI

Aiqun Lin,

Wenxia Zheng,

Yan He

et al.

Parkinsonism & Related Disorders, Journal Year: 2018, Volume and Issue: 53, P. 82 - 88

Published: Aug. 1, 2018

Language: Английский

Citations

221
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease DOI Creative Commons
Diane Bairamian, Sha Sha, Nathalie Rolhion

et al.

Molecular Neurodegeneration, Journal Year: 2022, Volume and Issue: 17(1)

Published: March 5, 2022

The implication of gut microbiota in the control brain functions health and disease is a novel, currently emerging concept. Accumulating data suggest that exert its action at least part by modulating neuroinflammation. Given link between neuroinflammatory changes neuronal activity, it plausible may affect indirectly impacting microglia, key player Indeed, increasing evidence suggests interplay microglia synaptic dysfunction involve microbiota, among other factors. In addition to these indirect microglia-dependent actions on has been recently recognized could also activity directly stimulation vagus nerve.

Language: Английский

Citations

207
Characterizing dysbiosis of gut microbiome in PD: evidence for overabundance of opportunistic pathogens DOI Creative Commons
Zachary D. Wallen, Mary Appah, Marissa Dean

et al.

npj Parkinson s Disease, Journal Year: 2020, Volume and Issue: 6(1)

Published: June 12, 2020

Abstract In Parkinson’s disease (PD), gastrointestinal features are common and often precede the motor signs. Braak colleagues proposed that PD may start in gut, triggered by a pathogen, spread to brain. Numerous studies have examined gut microbiome PD; all found it be altered, but inconsistent results on associated microorganisms. Studies date been small ( N = 20 306) difficult compare or combine due varied methodology. We conducted microbiome-wide association study (MWAS) with two large datasets for internal replication 333 507). used uniform methodology when possible, interrogated confounders, applied statistical tests concordance, followed correlation network analysis infer interactions. Fifteen genera were at significance level, both datasets, methods, without covariate adjustment. The associations not independent, rather they represented three clusters of co-occurring Cluster 1 was composed opportunistic pathogens elevated PD. 2 short-chain fatty acid (SCFA)-producing bacteria reduced 3 carbohydrate-metabolizing probiotics Depletion anti-inflammatory SCFA-producing levels confirmatory. Overabundance is an original finding their identity provides lead experimentally test role

Language: Английский

Citations

191
The Microbiome as a Modifier of Neurodegenerative Disease Risk DOI Creative Commons
Ping Fang, Sabeen A. Kazmi, Kelly G. Jameson

et al.

Cell Host & Microbe, Journal Year: 2020, Volume and Issue: 28(2), P. 201 - 222

Published: Aug. 1, 2020

Language: Английский

Citations

191