Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression

Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)

Published: June 6, 2022

Abstract Major depressive disorder is a highly debilitating psychiatric involving the dysfunction of different cell types in brain. Microglia are predominant resident immune cells brain and exhibit critical role depression. Recent studies have suggested that depression can be regarded as microglial disease. regulate inflammation, synaptic plasticity, formation neural networks, all which affect In this review, we highlighted microglia pathology First, described activation animal models clinically depressed patients. Second, emphasized possible mechanisms by recognize depression-associated stress conditions. Third, how antidepressants (clinical medicines natural products) activation. Thus, review aimed to objectively analyze focus on potential antidepressants. These data regulation actions might novel therapeutic strategy counteract adverse effects devastating mental disorders.

Language: Английский

---

Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(10), P. 1203 - 1203

Published: Sept. 28, 2022

Major depressive disorder (MDD) is a common and complex mental disorder, that adversely impacts an individual’s quality of life, but its diagnosis treatment are not accurately executed symptom-based approach utilized in most cases, due to the lack precise knowledge regarding pathophysiology. So far, first-line treatments still based on monoamine neurotransmitters. Even though there lot progress this field, mechanisms seem get more confusing, also getting controversial. In study, we try review broad advances neurotransmitters field MDD, update effects many advanced neuroscience studies. We propose hypothesis paid special attention their new pathways for such as inflammation, oxidative stress, neurotrophins, neurogenesis, especially glial cells, which have recently been found play important role neurodegenerative disorders, including MDD. addition, will extend basic emotions; suggested our previous reports, three different roles emotions: dopamine—joy, norepinephrine—fear (anger), serotonins—disgust (sadness). Above all, paper tries give full picture relationship between MDD DA, NE, 5-HT, well contributions Three Primary Color Model Basic Emotions (joy, fear, disgust). This done by explaining contribution from sides digestive tract, astrocytes, microglial, others, very briefly addressing potential therapeutic patients reasons limited clinical efficacy, side effects, delayed onset action. hope might offer pharmacological management

Language: Английский

---

The Impact of Nutrients on Mental Health and Well-Being: Insights From the Literature

Frontiers in Nutrition, Journal Year: 2021, Volume and Issue: 8

Published: March 8, 2021

A good nutritional status is important for maintaining normal body function and preventing or mitigating the dysfunction induced by internal external factors. Nutritional deficiencies often result in impaired function, and, conversely, intakes at recommended levels can resume further enhance functions. An increasing number of studies are revealing that diet nutrition critical not only physiology composition, but also have significant effects on mood mental well-being. In particular, Western dietary habits been object several research focusing relationship between health. This review aims to summarize current knowledge about intake specific micro- macronutrients, including eicosapentaenoic acid, docosahexaenoic alpha-tocopherol, magnesium folic health, with particular reference their beneficial effect stress, sleep disorders, anxiety, mild cognitive impairment, as well neuropsychiatric all significantly affecting quality life an people. Overall data support a positive role nutrients mentioned above preservation brain well-being, through control neuroinflammation, encourage integration well-balanced varied diet, accompanied healthy lifestyle. strategy importance when considering global human aging suffers from life-long impact stress

Language: Английский

---

Extracellular vesicle‐mediated delivery of circDYM alleviates CUS‐induced depressive‐like behaviours

Journal of Extracellular Vesicles, Journal Year: 2022, Volume and Issue: 11(1)

Published: Jan. 1, 2022

Abstract Major depressive disorder (MDD) is the most prevalent psychiatric worldwide and severely limits psychosocial function quality of life, but no effective medication currently available. Circular RNAs (circRNAs) have been revealed to participate in MDD pathological process. Targeted delivery circRNAs without blood‐brain barrier (BBB) restriction for remission represents a promising approach antidepressant therapy. In this study, RVG‐circDYM‐extracellular vesicles (RVG‐circDYM‐EVs) were engineered target preferentially transfer circDYM brain, effect on process chronic unpredictable stress (CUS) mouse model depression was investigated. The results showed that RVG‐circDYM‐EVs successfully purified by ultracentrifugation from overexpressed HEK 293T cells, characterization demonstrated terms size, morphology specific markers. Beyond demonstrating proof‐of‐concept an RNA drug technology, we observed systemic administration efficiently delivered alleviated CUS‐induced depressive‐like behaviours, discovered notably inhibited microglial activation, BBB leakiness peripheral immune cells infiltration, attenuated astrocyte disfunction induced CUS. CircDYM can bind mechanistically transcription factor TAF1 (TATA‐box binding protein associated 1), resulting decreased expression its downstream genes with consequently suppressed neuroinflammation. Taken together, our findings suggest extracellular vesicle‐mediated treatment clinical applications.

Language: Английский

---

Inflammation, Lifestyle Factors, and the Microbiome‐Gut‐Brain Axis: Relevance to Depression and Antidepressant Action

Clinical Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 113(2), P. 246 - 259

Published: March 12, 2022

Depression is considered a major public health concern, where existing pharmacological treatments are not equally effective across all patients. The pathogenesis of depression involves the interaction complex biological components, such as immune system and microbiota‐gut‐brain axis. Adjunctive lifestyle‐oriented approaches for depression, including physical exercise special diets promising therapeutic options when combined with traditional antidepressants. However, mechanisms action these strategies incompletely understood. Accumulating evidence suggests that specific dietary regimens can modulate both gut microbiota composition. Here, we review current information about to alleviate their crosstalk inflammatory microbiome. We further discuss role axis possible mediator adjunctive therapies through mechanisms. Finally, future manipulate potential use exercise, interventions, prebiotics/probiotics, fecal transplantation.

Language: Английский

---

Stress induced microglial activation contributes to depression

Pharmacological Research, Journal Year: 2022, Volume and Issue: 179, P. 106145 - 106145

Published: Feb. 24, 2022

Language: Английский

---

Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: April 28, 2023

Considerable evidence has been reported that tobacco use could cause alterations in gut microbiota composition. The microbiota-gut-brain axis also turn hinted at a possible contribution of the to smoking. However, population-level studies with higher level for causality are lacking.

Language: Английский

---

Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice

Phytomedicine, Journal Year: 2023, Volume and Issue: 113, P. 154725 - 154725

Published: Feb. 26, 2023

Language: Английский

---

Brain region–specific action of ketamine as a rapid antidepressant

Science, Journal Year: 2024, Volume and Issue: 385(6709)

Published: Aug. 8, 2024

Ketamine has been found to have rapid and potent antidepressant activity. However, despite the ubiquitous brain expression of its molecular target,

Language: Английский

---

PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107300 - 107300

Published: July 9, 2024

Depression is a serious global mental disorder. Numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction. The pathogenesis of complex involves multiple signal transduction pathways molecular changes. PI3K/AKT pathway an essential signaling in neurons, which widely expressed emotion-related regions the brain. Therefore, play moderating role mood disorders. However, mechanism not been fully described. This review systematically summarized discussed its potential treatment depression. will help development antidepressants.

Language: Английский

---