Molecular basis underlying changes of brain entropy and functional connectivity in major depressive disorders after electroconvulsive therapy

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(3)

Published: March 1, 2024

Abstract Introduction Electroconvulsive therapy (ECT) is widely used for treatment‐resistant depression. However, it unclear whether/how ECT can be targeted to affect brain regions and circuits in the dynamically regulate mood cognition. Methods This study entropy (BEN) measure irregular levels of systems 46 major depressive disorder (MDD) patients before after treatment. Functional connectivity (FC) was further adopted reveal changes functional couplings. Moreover, transcriptomic neurotransmitter receptor data were genetic molecular basis BEN connectivities. Results Compared pretreatment, posterior cerebellar lobe (PCL) significantly decreased FC between PCL right temporal pole (TP) increased MDD we found that these closely associated with genes' expression profiles involved MAPK signaling pathway, GABAergic synapse, dopaminergic synapse correlated receptor/transporter density 5‐HT, norepinephrine, glutamate, etc. Conclusion These findings suggest loops cerebellum TP are crucial regulation cognition, which provides new evidence antidepressant effects potential mechanism leading cognitive impairment.

Language: Английский

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Influence of physical exercise on negative emotions in college students: chain mediating role of sleep quality and self-rated health

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 2, 2024

Negative emotions in college students are a significant factor affecting mental health, with suicide behaviors caused by negative showing an annual increasing trend. Existing studies suggest that physical exercise is essential to alleviate feelings, yet the intrinsic mechanisms which it affects have not been fully revealed.

Language: Английский

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Glymphatic Dysfunction Induced Oxidative Stress and Neuro-Inflammation in Major Depression Disorders

Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2296 - 2296

Published: Nov. 20, 2022

Major Depression disorder (MDD) is a potentially life-threatening mental illness, however, many patients have poor response to current treatments. Recent studies suggested that stress- or trauma-induced oxidative stress and inflammation could be important factors involved in the development of MDD, but mechanisms remain unclear. We showed glymphatic system recently discovered structure brain may clearance large molecular cell debris extracellular space. In addition, can help with removal reactive oxygen species (ROS) cytokines such as IL-1β HIF-1α. Glymphatic impairment lead ROS accumulation microenvironment, inducing cellular injury signaling activating NLRP3 microglia induce and, thus, diseases, including psychiatric disorders. Therefore, inflammation, thus MDD. This paper will review recent advances regard stress-induced ROS-mediated

Language: Английский

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Niosomal Bupropion: Exploring Therapeutic Frontiers through Behavioral Profiling

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(3), P. 366 - 366

Published: March 12, 2024

Bupropion (Bup) belongs to the norepinephrine–dopamine reuptake inhibitor (NDRI) class and it is only FDA-approved drug of its for treatment major depressive disorder (MDD), sold under name Wellbutrin. Although bupropion effective in suppressing symptoms, regular use overdose might lead seizures liver failure. Thus, we aimed nanoformulate onto a niosomal vesicle improve efficacy achieve same therapeutic effect at lower scheduled doses. A thin film hydration method was adopted synthesize optimize Bup entrapped niosomes using three different surfactants sorbitan ester series (Span 20, 40, 60) combination with cholesterol. The optimization data determined that niosome formulated cholesterol-to-surfactant ratio 1:1.5 most stable system, containing Span 20 (Bup@N20C) exhibiting minimal vitro vivo toxicity, demonstrating sustained release artificial cerebrospinal fluid (ACSF). Bup@N20C formulation showed increased exploration activity reduced irregular movements reserpine-induced depression adult zebrafish model, suggesting potential mood improvement through suppression depression-like behavior which established by statistical analysis trajectory data. Bup@N20C-treated group even surpasses positive control comparable group. Hence, can be inferred formulations represent promising delivery system capable achieving brain cargo bypassing blood–brain barrier facilitated their small architectural structure.

Language: Английский

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Early Life Stress and Major Depressive Disorder—An Update on Molecular Mechanisms and Synaptic Impairments

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 6469 - 6483

Published: Feb. 3, 2024

Language: Английский

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Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(12), P. 2742 - 2742

Published: Dec. 8, 2022

Intranasal administration has gained an increasing interest for brain drug delivery since it allows direct transport through neuronal pathways, which can be quite advantageous central nervous system disorders, such as depression and anxiety. Nanoparticles have been studied possible alternatives to conventional formulations, with the objective of improving bioavailability. The present work aimed analyze potential intranasal nanoparticle treatment anxiety, using analysis several studies already performed. From carried-out analysis, was concluded that use nanoparticles drug’s protection from enzymatic degradation, modulation its components controlled release enhanced permeation. Furthermore, results in vivo further verified these systems’ potential, reaching faster leading increased bioavailability and, consequently, therapeutic effect. Hence, general, leads a onset action, prolonged concentrations effects, presenting high alternative currently available therapies

Language: Английский

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Flavonols in Action: Targeting Oxidative Stress and Neuroinflammation in Major Depressive Disorder

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 6888 - 6888

Published: April 7, 2023

Major depressive disorder is one of the most common mental illnesses that highly impairs quality life. Pharmacological interventions are mainly focused on altered monoamine neurotransmission, which considered primary event underlying disease's etiology. However, many other neuropathological mechanisms contribute to progression and clinical symptoms have been identified. These include oxidative stress, neuroinflammation, hippocampal atrophy, reduced synaptic plasticity neurogenesis, depletion neurotrophic factors, dysfunction hypothalamic-pituitary-adrenal (HPA) axis. Current therapeutic options often unsatisfactory associated with adverse effects. This review highlights relevant findings concerning role flavonols, a ubiquitous class flavonoids in human diet, as potential antidepressant agents. In general, flavonols be both an effective safe option management depression, largely based their prominent antioxidative anti-inflammatory Moreover, preclinical studies provided evidence they capable restoring neuroendocrine control HPA axis, promoting alleviating depressive-like behavior. Although these promising, still far from being implemented practice. Hence, further needed more comprehensively evaluate respect improvement signs depression.

Language: Английский

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Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 17, 2023

Abstract Despite extensive research on astrocytic Ca 2+ in synaptic transmission, its contribution to the modulation of sensory transmission during different brain states remains largely unknown. Here, by using two-photon microscopy and whole-cell recordings, we show two distinct signals murine barrel cortex: a small, long-lasting increase sleep large, widespread but short-lasting spike when aroused. The large wave aroused mice was inositol trisphosphate (IP3)-dependent, evoked locus coeruleus-norepinephrine system, enhanced input, contributing reliable transmission. However, small transient IP3-independent contributed decreased extracellular K + , hyperpolarization neurons, suppression These events respond pharmacological inputs contribute arousal functions modulating efficacy Together, our data demonstrate an important function for astrocytes via waves.

Language: Английский

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Antidepressant effects of coumarins and their derivatives: A critical analysis of research advances

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 956, P. 175958 - 175958

Published: Aug. 4, 2023

Coumarins and their derivatives are non-flavonoids polyphenols with diverse pharmacological activities including anti-depressant effects. This study systematically examines the antidepressant effects of coumarins in relation to time series research progress pathways, association other diseases, toxicity bliometric analysis. The review was approached using Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) coupled R package Biblioshiny, a web interface Bibliometrix analysis VOSviewer software analytic tools. Literature searches were conducted Scopus, Web Science, PubMed from inception through January 21, 2023. Coumarins, depression, coumarin treatment main search terms used which resulted inclusion 46 eligible publications. Scopoletin, psoralen, 7-hydroxycoumarin, meranzin hydrate, osthole, esculetin/umbelliferone most studied exerted stronger affinity monoamine oxidase-B (MAO-B) inhibition and, inhibitory effect via neurotransmitter pathway on MAO is well-studied. However, epigenetic modification, neuroendocrine, neurotrophic pathways understudied. Recent focuses targeted cytokines fibromyalgia. There link between gut microbiome, brain, depression; hydrate exerts an activity by remodelling gastrointestinal system. We established that empirical data some support limited. Likewise, safe dosage range several yet be fully determined.

Language: Английский

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Neuroendocrine pathogenesis of perimenopausal depression

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: March 30, 2023

With the development of social economics and increase working pressure, more women are suffering from long-term serious stress showing symptoms perimenopausal depression (PMD). The incidence rate PMD is increasing, physical mental health seriously affected. However, due to lack accurate knowledge pathophysiology, its diagnosis treatment cannot be accurately executed. By consulting relevant literature in recent years, this paper elaborates neuroendocrine mechanism aspects epigenetic changes, monoamine neurotransmitter receptor hypothesis, glial cell-induced neuroinflammation, estrogen receptor, interaction between HPA axis HPG axis, micro-organism-brain gut axis. purpose probe into new ways by providing about PMD.

Language: Английский

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