Unraveling the intricate relationship between lipid metabolism and oncogenic signaling pathways DOI Creative Commons
Fahad Khan,

Deena Elsori,

Meenakshi Verma

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: June 12, 2024

Lipids, the primary constituents of cell membrane, play essential roles in nearly all cellular functions, such as cell-cell recognition, signaling transduction, and energy provision. Lipid metabolism is necessary for maintenance life since it regulates balance between processes synthesis breakdown. Increasing evidence suggests that cancer cells exhibit abnormal lipid metabolism, significantly affecting their malignant characteristics, including self-renewal, differentiation, invasion, metastasis, drug sensitivity resistance. Prominent oncogenic pathways modulate metabolic gene expression elevate enzyme activity include phosphoinositide 3-kinase (PI3K)/AKT, MAPK, NF-kB, Wnt, Notch, Hippo pathway. Conversely, when are not regulated, they can lead to malfunctions signal transduction pathways. This, turn, enables uncontrolled growth by providing energy, building blocks, redox potentials. Therefore, targeting metabolism-associated could be an effective therapeutic approach decrease incidence promote survival. This review sheds light on interactions reprogramming cancer. Exploring a target provide promising creating anticancer treatments identifying inhibitors. Additionally, we have also provided overview drugs this review.

Language: Английский

Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications DOI Creative Commons
Xinyang Zhong, Xuefeng He, Yaxian Wang

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Nov. 1, 2022

Colorectal cancer (CRC) is the third most common and second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark cancer, Warburg effect promotes metastasis remodels tumor microenvironment, including promoting angiogenesis, immune suppression, cancer-associated fibroblasts formation drug resistance. Targeting metabolism would be promising method for treatment CRC. In this review, we summarize information about roles in microenvironment to elucidate mechanisms governing identify novel targets therapy.

Language: Английский

Citations

154
Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications DOI Creative Commons
Qian Zhong,

Xina Xiao,

Yijie Qiu

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(3)

Published: May 2, 2023

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent bonds on backbones amino acid side chains proteins and expand diversity proteins, which provides basis for emergence organismal complexity. To date, more than 650 types protein modifications, such as most well-known phosphorylation, ubiquitination, glycosylation, methylation, SUMOylation, short-chain long-chain acylation redox irreversible have been described, inventory is still increasing. By changing conformation, localization, activity, stability, charges, interactions with other biomolecules, PTMs ultimately alter phenotypes biological processes cells. The homeostasis important human health. Abnormal may cause changes in properties loss functions, are closely related occurrence development various diseases. In this review, we systematically introduce characteristics, regulatory mechanisms, functions health addition, therapeutic prospects diseases by targeting associated enzymes also summarized. This work will deepen understanding promote discovery diagnostic prognostic markers drug targets

Language: Английский

Citations

119
Exosomal circRNA: emerging insights into cancer progression and clinical application potential DOI Creative Commons
Fan Zhang, Jiajia Jiang, Hui Qian

et al.

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: June 26, 2023

Abstract Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as immune fibroblasts, other components, thereby regulating critical aspects of cancer progression including escape, angiogenesis, metabolism, drug resistance, proliferation metastasis. Interestingly, microenvironment have new findings in influencing escape mediated by the release exosomal circRNA. Given intrinsic stability, abundance, broad distribution circRNAs, they represent excellent diagnostic prognostic biomarkers for liquid biopsy. Moreover, artificially synthesized circRNAs may open up possibilities therapy, potentially bolstered nanoparticles or plant exosome delivery strategies. In this review, we summarize functions underlying mechanisms cell non-tumor cell-derived progression, with special focus on their roles immunity metabolism. Finally, examine potential application therapeutic targets, highlighting promise clinical use.

Language: Английский

Citations

96
The role of AMPK in cancer metabolism and its impact on the immunomodulation of the tumor microenvironment DOI Creative Commons

Chenicheri K. Keerthana,

Tennyson P. Rayginia,

Sadiq C. Shifana

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 15, 2023

Adenosine monophosphate-activated protein kinase (AMPK) is a key metabolic sensor that pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse and physiological effects besides its fundamental role in glucose lipid metabolism. Aberrancy signaling one determining factors which lead development chronic diseases such as obesity, inflammation, diabetes, cancer. The activation downstream cascades orchestrate dynamic changes tumor bioenergetics. It well documented possesses suppressor context progression by modulating inflammatory pathways. In addition, plays central potentiating phenotypic functional reprogramming various classes immune cells reside microenvironment (TME). Furthermore, AMPK-mediated responses facilitate recruitment certain types TME, impedes development, progression, metastasis Thus, appears play an important regulation anti-tumor response regulating plasticity cells. effectuates modulation immunity via nutrient TME virtue molecular crosstalk with major checkpoints. Several studies including from our lab emphasize on anticancer several phytochemicals, are potential drug candidates. scope this review encompasses significance cancer metabolism influence drivers within special emphasis use phytochemicals target combat

Language: Английский

Citations

88
Cancer metabolites: promising biomarkers for cancer liquid biopsy DOI Creative Commons
Wenxiang Wang, Zhiwei Rong, Guangxi Wang

et al.

Biomarker Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: June 30, 2023

Abstract Cancer exerts a multitude of effects on metabolism, including the reprogramming cellular metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation cancer cells adaptation to tumor microenvironment. There is growing body evidence suggesting aberrant play pivotal roles tumorigenesis metastasis, have potential serve as biomarkers for personalized therapy. Importantly, high-throughput metabolomics detection techniques machine learning approaches offer tremendous clinical oncology by enabling identification cancer-specific metabolites. Emerging research indicates circulating great promise noninvasive detection. Therefore, this review summarizes reported abnormal cancer-related last decade highlights application liquid biopsy, specimens, technologies, methods, challenges. The provides insights into promising tool applications.

Language: Английский

Citations

46
PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti‐PD‐1 Immunotherapy DOI Creative Commons

Yi-Min Zheng,

Yining Wang, Lu Zhou

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(29)

Published: Sept. 14, 2023

Abstract The combination of immunotherapy and molecular targeted therapy exhibits promising therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still unclear. Here, phosphoglycerate mutase 1 (PGAM1) identified as a novel immunometabolic target by using bioinformatic algorithm based on multiple HCC datasets. PGAM1 highly expressed associated with poor prognosis response to immunotherapy. In vitro vivo experiments indicate that targeting inhibited cell growth promoted infiltration CD8 + T‐cells due decreased enzymatic activity. Mechanistically, inhibition promotes ferroptosis downregulating Lipocalin (LCN2) inducing energy stress ROS‐dependent AKT inhibition, which can also downregulate Programmed death 1‐ligand (PD‐L1). Moreover, an allosteric inhibitor (KH3) good antitumor effects patient‐derived xenograft (PDX) models enhanced anti‐PD‐1 subcutaneous orthotopic models. Taken together, findings demonstrate exerts effect promoting T‐cell synergize HCC. Targeting be new strategy “killing two birds one stone” for treatment.

Language: Английский

Citations

43
The role of AMPK in macrophage metabolism, function and polarisation DOI Creative Commons

Yinxing Cui,

Junhua Chen, Zhao Zhang

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Dec. 8, 2023

AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status in eukaryotic cells. It plays key role regulating cellular homeostasis multiple aspects cell metabolism. During macrophage polarisation, AMPK not only guides the metabolic programming macrophages, but also counter-regulates inflammatory function macrophages promotes their polarisation toward anti-inflammatory phenotype. located at intersection metabolism inflammation. The characteristics are closely related to immune-related diseases, infectious cancer progression immunotherapy. This review discusses structure its metabolism, macrophages. In addition, it summarises important pathway activators development macrophage-related diseases.

Language: Английский

Citations

43
Tumor microenvironment as a complex milieu driving cancer progression: a mini review DOI Creative Commons
Zhengrui Li, Jing Li,

Xiaolei Bai

et al.

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Language: Английский

Citations

19
Biodegradable Ferrous Sulfide-Based Nanocomposites for Tumor Theranostics through Specific Intratumoral Acidosis-Induced Metabolic Symbiosis Disruption DOI
Jingjing Wang, Zhaoli Sun,

Shuren Wang

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(43), P. 19884 - 19895

Published: Oct. 2, 2022

Abnormal metabolic symbiosis is a typical characteristic that differentiates the tumor regions from healthy tissues and meanwhile maintains survival. It of great potential to disrupt intratumoral in therapy. Herein, we report specific therapy strategy through inducing acidosis for elimination, which based on carbonic anhydrase inhibitor (CAI)-modified ferrous sulfide nanoparticles (FeS-PEG-CAI NPs). The FeS-PEG-CAI NPs show acid-responsive degradation capacity release functional components, including CAI, Fe2+, H2S, while remaining quite stable under normal physiological conditions. generated CAI H2S gas can not only intracellular induce but also provide suitable circumstances Fe2+-mediated Fenton reaction, producing abundant toxic hydroxyl radicals. Meanwhile, these dual-mode imaging with photoacoustic magnetic resonance imaging, dynamically monitor location process synergistic chemodynamic/photothermal/gas Overall, developed exert their role disrupting other effects, further enrich treatment strategies.

Language: Английский

Citations

61
LncRNAs in tumor metabolic reprogramming and immune microenvironment remodeling DOI

Jiecheng Yang,

Fangzhou Liu, Ying Wang

et al.

Cancer Letters, Journal Year: 2022, Volume and Issue: 543, P. 215798 - 215798

Published: June 21, 2022

Language: Английский

Citations

58