Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities DOI Creative Commons
Junshu Li, Wencheng Zhou, Huiling Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 24, 2024

Exosomes can regulate the malignant progression of tumors by carrying a variety genetic information and transmitting it to target cells. Recent studies indicate that exosomal circular RNAs (circRNAs) multiple biological processes in carcinogenesis, such as tumor growth, metastasis, epithelial-mesenchymal transition, drug resistance, autophagy, metabolism, angiogenesis, immune escape. In microenvironment (TME), circRNAs be transferred among cells, endothelial cancer-associated fibroblasts, microbiota, affecting initiation progression. Due high stability widespread presence circRNAs, they hold promise biomarkers for diagnosis prognosis prediction blood urine. addition, designing nanoparticles targeting utilizing derived from cells or stem provide new strategies cancer therapy. this review, we examined crucial role regulating tumor-related signaling pathways summarized transmission between various types their impact on TME. Finally, our review highlights potential diagnostic prognostic biomarkers, well suggesting clinical

Language: Английский

New insight into circRNAs: characterization, strategies, and biomedical applications DOI Creative Commons

Xin-Yi Feng,

Shun-Xin Zhu,

Ke‐Jia Pu

et al.

Experimental Hematology and Oncology, Journal Year: 2023, Volume and Issue: 12(1)

Published: Oct. 12, 2023

Abstract Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most circRNAs derived from exonic or intronic sequences by precursor RNA back-splicing. Advanced high-throughput sequencing and experimental technologies have enabled the extensive identification characterization circRNAs, such as novel types biogenesis, tissue-specific cell-specific expression patterns, epigenetic regulation, translation potential, localization metabolism. Increasing evidence has revealed that participate in diverse cellular processes, their dysregulation is involved pathogenesis various diseases, particularly cancer. In this review, we systematically discuss databases, challenges for circRNA discovery, new insight into strategies used studies biomedical applications. Although recent advanced understanding knowledge approaches annotation, functional applications continuously needed to provide insights circRNAs. The emergence circRNA-based protein strategy will be promising direction field biomedicine.

Language: Английский

Citations

54
Circular RNA in cancer DOI
Vanessa M. Conn, Arul M. Chinnaiyan, Simon J. Conn

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(9), P. 597 - 613

Published: July 29, 2024

Language: Английский

Citations

47
Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma DOI Creative Commons

Yau-Tuen Chan,

Cheng Zhang, Junyu Wu

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 6, 2024

Language: Английский

Citations

42
Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death DOI Creative Commons
Chi Zhou, Wenxin Li, Liang Zhenxing

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 12, 2024

Abstract Mutant KRAS (KRAS MUT ) is often exploited by cancers to shape tumor immunity, but the underlying mechanisms are not fully understood. Here we report that tumor-specific cytotoxic T lymphocytes (CTLs) from sensitive activation-induced cell death (AICD). circATXN7, an NF-κB-interacting circular RNA, governs sensitivity AICD inactivating NF-κB. Mechanistically, histone lactylation derived cell-produced lactic acid directly activates transcription of which binds NF-κB p65 subunit and masks nuclear localization signal motif, thereby sequestering it in cytoplasm. Clinically, circATXN7 upregulation CTLs correlates with adverse clinical outcomes immunotherapeutic resistance. Genetic ablation circAtxn7 CD8 + cells leads mutant-selective inhibition, while also increases anti-PD1 efficacy multiple models female mice. Furthermore, targeting adoptively transferred tumor-reactive improves their antitumor activities. These findings provide insight into how lymphocyte-expressed circRNAs contribute T-cell fate decisions anticancer immunotherapies.

Language: Английский

Citations

30
Glycolysis reprogramming in CAFs promotes oxaliplatin resistance in pancreatic cancer through circABCC4 mediated PKM2 nuclear translocation DOI Creative Commons

Rihua He,

Chonghui Hu, Yuan Yuan

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 23, 2025

Language: Английский

Citations

3
CircKIAA0182 Enhances Lung Cancer Progression and Chemoresistance through Interaction with YBX1 DOI
Masha Huang,

Jingyi Sun,

Qingqing Jiang

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 612, P. 217494 - 217494

Published: Jan. 23, 2025

Language: Английский

Citations

2
GC-derived exosomal circMAN1A2 promotes cancer progression and suppresses T-cell antitumour immunity by inhibiting FBXW11-mediated SFPQ degradation DOI Creative Commons
Yikai Shen, Jie Lin,

Tianlu Jiang

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 25, 2025

Abstract Background Exosomes, as extracellular membrane vesicles, play important roles in intercellular communication and can influence tumour progression. Circular RNAs (circRNAs) have been reported various malignancies are also components of exosomes. However, the role exosomal circRNAs gastric cancer (GC) progression has not completely clarified. Methods The enriched GC were identified using circRNA sequencing. biological function circMAN1A2 was investigated a series vitro vivo experiments. PKH-67 staining used to label molecular mechanism via mass spectrometry, immunoprecipitation, Western blot, single-cell RNA-sequencing data analyses. Results In our study, we determined that (hsa_circ_0000118) GC-derived Higher expression related poor survival patients (HR = 2.917, p 0.0120). Exosomal promoted suppressed antitumour activity T cells. Moreover, bound SFPQ cells cells, promoting G1/S phase transition cell cycle while inhibiting activation receptor signalling pathway decrease activity. Mechanistically, competed with FBXW11 for binding SFPQ, preventing FBXW11-mediated k48-linked ubiquitination protein degradation, thereby stabilizing expression. Conclusions Our work confirms critical immunosuppression GC. This novel axis circMAN1A2-SFPQ provides new insights into circRNA-based diagnostic therapeutic strategies.

Language: Английский

Citations

2
Immunoregulatory role of exosomal circRNAs in the tumor microenvironment DOI Creative Commons
Changsheng Lv,

Jinhao Chen,

Yuxiang Wang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 17, 2025

As cancer incidence and mortality rates rise, there is an urgent need to develop effective immunotherapy strategies. Circular RNA (circRNA), a newly identified type of non-coding RNA, abundant within cells can be released via exosomes, facilitating communication between cells. Studies have demonstrated that exosomal circRNAs alter the tumor microenvironment modulate immune responses by influencing functions T cells, natural killer (NK) macrophages, thereby enabling tumors evade system. Moreover, show potential as diagnostic biomarkers therapeutic targets for cancer. This review summarizes regulatory roles in their applications progression treatment, highlighting promise improving immunotherapy. Future research should concentrate on understanding mechanisms key developing targeted methods.

Language: Английский

Citations

2
Circular RNAs in neurological conditions – computational identification, functional validation, and potential clinical applications DOI Creative Commons

Oak Hatzimanolis,

Alex M. Sykes, Alexandre S. Cristino

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Non-coding RNAs (ncRNAs) have gained significant attention in recent years due to advancements biotechnology, particularly high-throughput total RNA sequencing. These developments led new understandings of non-coding biology, revealing that approximately 80% regions the genome possesses biochemical functionality. Among ncRNAs, circular (circRNAs), first identified 1976, emerged as a prominent research field. CircRNAs are abundant most human cell types, evolutionary conserved, highly stable, and formed by back-splicing events which generate covalently closed ends. Notably, circRNAs exhibit high expression levels neural tissue perform diverse functions, including acting molecular sponges for microRNAs, interacting with RNA-binding proteins regulate their availability activity, modulating transcription splicing, even translating into functional peptides some cases. Recent computational experimental methods enhanced our ability identify validate circRNAs, providing valuable insights biological roles. This review focuses on circRNA they related neuropsychiatric neurodegenerative conditions. We also explore potential applications clinical diagnostics, therapeutics, future directions. remain relatively underexplored area context neurological disorders. However, emerging evidence supports role critical players etiology mechanisms conditions such schizophrenia, bipolar disorder, major depressive Alzheimer’s disease, Parkinson’s disease. findings suggest may provide novel framework contributing dysfunctions underpinning these complex

Language: Английский

Citations

2
Environmental pollutants and exosomes: A new paradigm in environmental health and disease DOI
Afsaneh Javdani-Mallak,

Iman Salahshoori

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 925, P. 171774 - 171774

Published: March 18, 2024

Language: Английский

Citations

16