Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology

Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 73 - 73

Published: Jan. 24, 2025

The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine

Language: Английский

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Neurodegenerative diseases and catechins: (−)-epigallocatechin-3-gallate is a modulator of chronic neuroinflammation and oxidative stress

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 1, 2024

Catechins, a class of phytochemicals found in various fruits and tea leaves, have garnered attention for their diverse health-promoting properties, including potential combating neurodegenerative diseases. Among these catechins, (-)-epigallocatechin-3-gallate (EGCG), the most abundant polyphenol green tea, has emerged as promising therapeutic agent due to its potent antioxidant anti-inflammatory effects. Chronic neuroinflammation oxidative stress are key pathological mechanisms diseases such Alzheimer's disease (AD) Parkinson's (PD). EGCG neuroprotective efficacy scavenging free radicals, reducing attenuating neuroinflammatory processes. This review discusses molecular EGCG's anti-oxidative chronic neuroinflammation, emphasizing effects on autoimmune responses, neuroimmune system interactions, focusing related AD PD. By elucidating action impact processes, this underscores intervention AD, PD, possibly other Overall, emerges natural compound stress, offering novel avenues strategies treatment disorders.

Language: Английский

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Selenium Attenuates Radiation Colitis by Regulating cGAS‐STING Signaling

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract Radiation colitis is one of the most common complications in patients undergoing pelvic radiotherapy and there no effective treatment clinic. Therefore, searching for agents radiation urgently needed. Herein, it found that essential element selenium (Se) protective against through inhibiting X‐ray‐induced apoptosis, cell cycle arrest, inflammation with involvement balancing generation reactive oxygen species after irradiation. Mechanistically, Se, especially nanoparticles (SeNPs), induced selenoprotein expression then functioned to effectively restrain DNA damage response, which reduced intestinal injury. Additionally, SeNPs also restrained cyclic GMP‐AMP synthas (cGAS)‐ stimulator interferon genes (STING)‐TBK1‐IRF3 signaling pathway cascade, thereby blocking transcription inflammatory cytokine gene, IL‐6 TNF‐α, thus alleviating inflammation. Moreover, inducing expression, such as GPX4, vivo can regulate microenvironment immunity gut microbiota attenuate radiation‐induced by oxidative stress maintaining homeostasis. Together, these results unravel a previously unidentified modulation role but suppressing cGAS‐STING‐TBK1‐IRF3 cascade.

Language: Английский

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Sargassum fusiforme and its fucoidan alleviates high-fat diet induced obesity associated with the improvement of the gut microbiota profile

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106686 - 106686

Published: Feb. 1, 2025

Language: Английский

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Crosstalk between intestinal flora and human iron metabolism: the role in metabolic syndrome-related comorbidities and its potential clinical application

Microbiological Research, Journal Year: 2024, Volume and Issue: 282, P. 127667 - 127667

Published: March 1, 2024

Language: Английский

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LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance, systemic inflammation, and mitochondrial morphology in a weaned piglet model

Science China Life Sciences, Journal Year: 2024, Volume and Issue: 67(9), P. 1970 - 1988

Published: June 21, 2024

Language: Английский

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Regulation of gut microbiota on immune cell ferroptosis: A novel insight for immunotherapy against tumor

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217115 - 217115

Published: July 17, 2024

Language: Английский

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The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106836 - 106836

Published: Feb. 1, 2025

Ischemic stroke (IS) is a cerebrovascular disease that predominantly affects middle-aged and elderly populations, exhibiting high mortality disability rates. At present, the incidence of IS increasing annually, with notable trend towards younger affected individuals. Recent discoveries concerning "gut-brain axis" have established connection between gut brain. Numerous studies revealed intestinal microbes play crucial role in onset, progression, outcomes IS. They are involved entire pathophysiological process through mechanisms such as chronic inflammation, neural regulation, metabolic processes. Although numerous explored relationship microbiota, comprehensive analyses specific microbiota relatively scarce. Therefore, this paper provides an overview typical changes following investigates microorganisms context. Additionally, it presents analysis post-stroke microbiological therapy diet. The aim to identify potential microbial targets for therapeutic intervention, well highlight benefits therapies significance dietary management. Overall, seeks provide key strategies treatment management IS, advocating healthy diets health programs Meanwhile, may offer new perspective on future interdisciplinary development neurology, microbiology nutrition.

Language: Английский

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The Gut Microbiota Metabolite Butyrate Modulates Acute Stress-Induced Ferroptosis in the Prefrontal Cortex via the Gut–Brain Axis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1698 - 1698

Published: Feb. 17, 2025

Stress has been implicated in the onset of mental disorders such as depression, with prefrontal cortex (PFC) playing a crucial role. However, underlying mechanisms remain to be fully elucidated. Metabolites secreted by intestinal flora can enter bloodstream and exert regulatory effects on body. Consequently, this study aims investigate molecular which gut influences ferroptosis PFC neurons, thereby affecting depression-like behavioral changes mice subjected acute stress. Initially, we established mouse model restraint stress (3-day duration) verified that stress-induced neurons contributed alterations mice, evidenced morphological, behavioral, biology assessments. Subsequently, through fecal microbiota transplantation (FMT) experiments, significant correlation between stress-exposed mice. 16S rDNA sequencing identified butyric acid-producing bacteria, specifically g_Butyricimonas its primary metabolite, acid, critical regulators acutely stressed Furthermore, intervention butyrate demonstrated potential ameliorate damage blood-brain barriers these This also mitigated behaviors induced alleviating systemic inflammatory responses. The findings indicate plays role Additionally, metabolite modulate gut-brain axis.

Language: Английский

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Research Progress of Bile Acids in Neurodegenerative Diseases

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1718 - 1724

Published: Jan. 1, 2025

Language: Английский

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