Bacterial indole-3-propionic acid inhibits macrophage IL-1β production through targeting methionine metabolism DOI
Ziyi Han, Jian Fu,

Aiyan Gong

et al.

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

EGCG drives gut microbial remodeling-induced epithelial GPR43 activation to lessen Th1 polarization in colitis DOI Creative Commons

Siyan Che,

Beibei Qin,

Kunfu Wu

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103291 - 103291

Published: July 30, 2024

Modulation of immune microenvironment is critical for inflammatory bowel disease (IBD) intervention. Epigallocatechin gallate (EGCG), as a natural low toxicity product, has shown promise in treating IBD. However, whether and how EGCG regulates the intestinal not fully understood. Here we report that lessens colitis by orchestrating Th1 polarization self-amplification novel manner required multilevel-regulated microecosystem. Mechanistically, activates GPR43 on IEC to inhibit dependently short chain fatty acid (SCFA)-producing gut microbiota. Inhibition activity weakens protective effects development. Moreover, confirm fecal SCFAs and/or are limited patients with correlated cell number. Taken together, our study reveals an microenvironment-dependent immunoregulatory IBD provides insight into mechanisms EGCG-based immunotherapeutic strategies

Language: Английский

Citations

4
Bifidobacterium pseudolongum‐Derived Bile Acid from Dietary Carvacrol and Thymol Supplementation Attenuates Colitis via cGMP‐PKG‐mTORC1 Pathway DOI Creative Commons
Ke Zhang, Yangbin Xu,

Yining Zheng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Carvacrol and thymol (CAT) have been widely recognized for their antimicrobial anti-inflammatory properties, yet specific effects on colitis the mechanisms involved remain insufficiently understood. This study establishes a causative link between CAT administration mitigation, primarily through enhancement of Bifidobacterium pseudolongum abundance in colon. increase promotes production secondary bile acids, particularly hyodeoxycholic acid (HDCA) 12-ketodeoxycholic (12-KCAC), which exert effects. Notably, does not alleviate symptoms germ-free mice, indicating necessity gut microbiota. research uncovers novel regulatory mechanism where HDCA 12-KCAC inhibit colonic inflammation by reducing expression transmembrane guanylate cyclase 1A epithelium. downregulation elevates intracellular Ca

Language: Английский

Citations

4
Poultry Nutrition: Achievement, Challenge and Strategy DOI
Kexin Cao,

Zhang‐Chao Deng,

Shijun Li

et al.

Journal of Nutrition, Journal Year: 2024, Volume and Issue: 154(12), P. 3554 - 3565

Published: Oct. 16, 2024

Language: Английский

Citations

4
Landscapes of gut microbiome and blood metabolomic signatures in relapsing remitting multiple sclerosis DOI
Jinzhou Feng, Shi Tang,

Xiao-Lin Yang

et al.

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

Citations

0
Bacterial indole-3-propionic acid inhibits macrophage IL-1β production through targeting methionine metabolism DOI
Ziyi Han, Jian Fu,

Aiyan Gong

et al.

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

Citations

0