The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment DOI Open Access
Hui Lyu,

Jinghua Kong,

Jiasi Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13334 - 13334

Published: Dec. 12, 2024

Pancreatic cancer remains one of the most lethal forms cancer. Currently, there is a lack effective drug treatments for pancreatic However, as newly discovered form non-apoptotic cell death, ferroptosis has garnered increasing attention in relation to Understanding role tumorigenesis and treatment may enable more clinical trials minimize side effects or restrict emergence resistance. In this review, we summarize current knowledge regarding process underlying mechanisms ferroptosis, well its dual both promoting facilitating strategies Additionally, how implicated development pancreatitis insulin resistance, indicating that play an important risk pancreatitis- insulin-resistance-related cancers, also addressed.

Language: Английский

Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1 DOI

Shimeng Zhou,

Yu Shi,

Jiang-ying Li

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nanocarriers Targeting Circular RNA ADARB1 Boost Radiosensitivity of Nasopharyngeal Carcinoma through Synergically Promoting Ferroptosis DOI
Dan Wang, Le Tang, Mingjian Chen

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(45), P. 31055 - 31075

Published: Oct. 28, 2024

Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, prevalent in regions such as Southern China Southeast Asia. Radiotherapy serves primary clinical treatment for this carcinoma. However, resistance to radiotherapy fundamental cause failure patient mortality, with underlying mechanisms yet be fully elucidated. We identified recently characterized circular RNA, circADARB1, which markedly upregulated NPC tissues closely associated poor prognosis resistance. Both vitro vivo experiments demonstrated that circADARB1 inhibited ferroptosis, thereby inducing cells. Building on these findings, we synthesized biomimetic nanomaterial consisting semiconducting polymer nanoparticles wrapped cell membranes, designed deliver both siRNA targeting iron ions. The application not only efficiently suppressed expression boosted intracellular concentrations, but also enhanced ferroptosis induced by radiotherapy, improving radiosensitivity Furthermore, our study revealed heat shock protein HSP90B1, repaired misfolded SLC7A11 GPX4 proteins triggered preserving their stability biological functions. Mechanistically, facilitated cysteine transportation into cells glutathione synthesis, while employed mitigate lipid peroxidation shielding from oxidative damage inhibiting ultimately leading Our investigation elucidates molecular substantial relevance, highlights promising prospects nanotechnology precision cancer therapy.

Language: Английский

Citations

3
circTP63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway DOI
Dan Wang,

Sicheng Zuo,

Junshang Ge

et al.

Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Language: Английский

Citations

2
The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment DOI Open Access
Hui Lyu,

Jinghua Kong,

Jiasi Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13334 - 13334

Published: Dec. 12, 2024

Pancreatic cancer remains one of the most lethal forms cancer. Currently, there is a lack effective drug treatments for pancreatic However, as newly discovered form non-apoptotic cell death, ferroptosis has garnered increasing attention in relation to Understanding role tumorigenesis and treatment may enable more clinical trials minimize side effects or restrict emergence resistance. In this review, we summarize current knowledge regarding process underlying mechanisms ferroptosis, well its dual both promoting facilitating strategies Additionally, how implicated development pancreatitis insulin resistance, indicating that play an important risk pancreatitis- insulin-resistance-related cancers, also addressed.

Language: Английский

Citations

0