Mechanisms associated with cuproptosis and implications for ovarian cancer DOI

Biqing Chen,

Jiaqi Liu

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 257, P. 112578 - 112578

Published: April 25, 2024

Language: Английский

The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm DOI Creative Commons
Thi Thuy Tien Vo, Tzu‐Yu Peng,

Thi Hong Nguyen

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 5, 2024

Abstract Copper is a crucial trace element that plays role in various pathophysiological processes the human body. also acts as transition metal involved redox reactions, contributing to generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated different types regulated cell death. The recent discovery cuproptosis, copper-dependent death pathway distinct from other known forms, raised interest researchers field cancer therapy. Herein, present work aims outline current understanding with an emphasis on its anticancer activities through interplay copper-induced stress, thereby providing new ideas for therapeutic approaches targeting modes future.

Language: Английский

Citations

29
Microwave‐Sintered Nano‐SiC Reinforced 8SiC/Ti‐3Cu Composite: Fabrication, Wear Resistance, Antibacterial Function, and Biocompatibility DOI
Xin Li, Ying‐Chao Zhao, Dengfeng Yin

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract The significance of biomedical applications Ti alloys is best emphasized by their widespread utilization as implantable materials, such internal supports and bone replacements. are sensitive to fretting wear, which leads the early failure implants. Improved wear resistance implants essential ensure a prolonged implant life. Based on structure‐function‐integrated concept, this work unprecedentedly designs fabricates an antibacterial 8SiC/Ti‐3Cu composite with improved using microwave sintering from pure Ti, Cu, nano‐SiC powders. For comparison, SiC‐free Ti‐3Cu manufactured under same conditions sintering. addition 8 vol.% SiC significantly reduces porosity pore size composites. shows Vickers hardness 353 HV, compressive strength 803 MPa, elastic modulus 28.7 GPa, increased (wear rate decreased 70% compared Ti‐3Cu). In addition, exhibits excellent electrochemical corrosion resistance, biocompatibility in relation MC3T3‐E1 cells, bacteriostatic over 99% against E. coli . combination wear‐resistant nano‐reinforced 2 Cu renders it highly promising material.

Language: Английский

Citations

2
Wilson’s Disease—Crossroads of Genetics, Inflammation and Immunity/Autoimmunity: Clinical and Molecular Issues DOI Open Access
Grażyna Gromadzka,

Julia Czerwińska,

Elżbieta Krzemińska

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9034 - 9034

Published: Aug. 20, 2024

Wilson's disease (WD) is a rare, autosomal recessive disorder of copper metabolism caused by pathogenic mutations in the

Language: Английский

Citations

7
Recent advances of PIWI‐interacting RNA in cardiovascular diseases DOI Creative Commons
Bo Li, Kai Wang, Wei Cheng

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(8)

Published: July 31, 2024

Abstract Background The relationship between noncoding RNAs (ncRNAs) and human diseases has been a hot topic of research, but the study ncRNAs in cardiovascular (CVDs) is still its infancy. PIWI‐interacting RNA (piRNA), small ncRNA that binds to PIWI protein maintain genome stability by silencing transposons, was widely studied germ lines stem cells. In recent years, piRNA shown be involved key events multiple CVDs through various epigenetic modifications, revealing potential value as new biomarker or therapeutic target. Conclusion This review explores origin, degradation, function, mechanism important role CVDs, promising targets were summarized. provide strategy for treatment lay theoretical foundation future research. Key points can used target biomaker CVDs. influences apoptosis, inflammation angiogenesis regulating modificaions. Critical knowledge gaps remain unifying nomenclature PIWI‐independent function.

Language: Английский

Citations

4
Quantity of cu(II) ions in a copper pot by a DNAzyme-based fluorescent sensor DOI Creative Commons
Dazhi Jiang, Shijin Wang, Chang‐Hao Yang

et al.

Food Chemistry Molecular Sciences, Journal Year: 2025, Volume and Issue: 10, P. 100249 - 100249

Published: Feb. 18, 2025

Language: Английский

Citations

0
Two birds with one stone: one-step preparation of fluorine-doped CDs with sensitive sensing of copper and visualization of latent fingerprints DOI
Chao Chen, Yihao Zhang,

Sineng Gao

et al.

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(3)

Published: Feb. 19, 2025

Language: Английский

Citations

0
TAK1 at the crossroads of multiple regulated cell death pathways: from molecular mechanisms to human diseases DOI Open Access
Kun Huang, Qí Zhāng, Hao Wan

et al.

FEBS Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Regulated cell death (RCD), the form of that can be genetically controlled by multiple signaling pathways, plays an important role in organogenesis, tissue remodeling, and maintenance organism homeostasis is closely associated with various human diseases. Transforming growth factor-beta-activated kinase 1 (TAK1) a member serine/threonine protein family, which respond to different internal external stimuli participate inflammatory immune responses. Emerging evidence suggests TAK1 regulator at crossroad RCD including apoptosis, necroptosis, pyroptosis, PANoptosis. The regulation affects disease progression through therapeutic strategies targeting have been proposed for diseases, central nervous system cancers. In this review, we provide overview downstream pathways regulated its binding proteins. Their critical regulatory roles forms are also summarized. addition, discuss potential treatment specific focus on neurological disorders cancer.

Language: Английский

Citations

0
Strategies to combat cancer drug resistance: focus on copper metabolism and cuproptosis DOI Open Access

Leyi Yao,

Baoyi Jiang,

Dacai Xu

et al.

Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Cancer cells often develop tolerance to chemotherapy, targeted therapy, and immunotherapy drugs either before or during treatment. The significant heterogeneity among various tumors poses a critical challenge in modern cancer research, particularly overcoming drug resistance. Copper, as an essential trace element the body, participates biological processes of diseases, including cancers. growth many types tumor exhibits heightened dependence on copper. Thus, targeting copper metabolism inducing cuproptosis may be potential ways overcome Copper chelators have shown resistance by copper-dependent cells. In contrast, ionophores, copper-based nanomaterials, other small molecules been used induce cell death (cuproptosis) cells, drug-resistant This review summarizes regulation role resistance, providing ideas for future.

Language: Английский

Citations

0
Expression of SLC2A1 is upregulated in a mouse model of age-related hearing loss DOI
Jiali Liu,

Haisen Peng,

Yuehui Liu

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: 131, P. 111776 - 111776

Published: March 30, 2025

Language: Английский

Citations

0
Effect of Sodium Para-Aminosalicylic Acid on Cuproptosis in PC12 Cells Exposed Manganese, Iron, and Copper DOI
Haitao Huang, Thanh-Tung Ho, Zhixin Huang

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

Citations

0