Frontiers in Molecular Biosciences,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 11, 2024
Ferroptosis,
an
iron-ion-dependent
process
of
lipid
peroxidation,
damages
the
plasma
membrane,
leading
to
non-programmed
cell
death.
Osteoarthritis
(OA),
a
prevalent
chronic
degenerative
joint
disease
among
middle-aged
and
older
adults,
is
characterized
by
chondrocyte
damage
or
loss.
Emerging
evidence
indicates
that
ferroptosis
plays
role
in
OA
development.
However,
most
research
has
concentrated
on
regulation
involving
typical
iron
ions,
potentially
neglecting
significance
elevated
copper
ions
both
serum
fluid
patients
with
OA.
This
review
aims
fill
this
gap
systematically
examining
interplay
between
metabolism,
oxidative
stress,
ferroptosis,
copper-associated
death
It
will
provide
comprehensive
overview
ions'
regulating
their
dual
approach
seeks
offer
new
insights
for
further
research,
prevention,
treatment
Clinical and Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Sept. 26, 2024
Abstract
Long
non-coding
RNAs
(lncRNAs)
have
emerged
as
crucial
regulators
in
various
cellular
processes,
including
cancer
progression
and
stress
response.
Recent
studies
demonstrated
that
copper
accumulation
induces
a
unique
form
of
cell
death
known
cuproptosis,
with
lncRNAs
playing
key
role
regulating
cuproptosis-associated
pathways.
These
may
trigger
cell-specific
responses
to
stress,
presenting
new
opportunities
prognostic
markers
therapeutic
targets.
This
paper
delves
into
the
cuproptosis-mediated
cancer,
underscoring
their
potential
biomarkers
targets
for
innovative
strategies.
A
thorough
review
scientific
literature
was
conducted,
utilizing
databases
such
PubMed,
Google
Scholar,
ScienceDirect,
search
terms
like
'lncRNAs,'
'cuproptosis,'
'cancer.'
Studies
were
selected
based
on
relevance
lncRNA
regulation
cuproptosis
pathways
implications
prognosis
treatment.
The
highlights
significant
contribution
cuproptosis-related
genes
pathways,
impacting
metabolism,
mitochondrial
responses,
apoptotic
signaling.
Specific
are
breast,
lung,
liver,
ovarian,
pancreatic,
gastric
cancers.
objective
this
article
is
explore
cancers
mediated
by
cuproptosis.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 17, 2025
Nanotherapy
has
emerged
as
a
promising
strategy
for
the
targeted
and
efficient
treatment
of
melanoma,
most
aggressive
lethal
form
skin
cancer,
with
minimized
systemic
toxicity.
However,
therapeutic
efficacy
cobalt
oxide
nanoparticles
(Co3O4NPs)
in
melanoma
remains
unexplored.
This
study
aimed
to
assess
potential
Co3O4NPs
by
evaluating
their
impact
on
cell
viability,
genomic
DNA
mitochondrial
integrity,
reactive
oxygen
species
(ROS)
generation
apoptosis
induction
A-375
cells.
Our
findings
demonstrated
concentration-dependent
reduction
viability
upon
five
Co3O4NP
concentrations
(0.2,
2,
20,
200,
2000
µg/ml),
an
IC50
value
303.80
µg/ml.
Treatment
this
concentration
significantly
increased
ROS
generation,
induced
dramatic
damage,
disrupted
membrane
integrity.
Flow
cytometric
analysis
revealed
necrosis
following
exposure
at
value.
Results
qRT-PCR
remarkable
dysregulation
apoptotic
genes,
including
significant
downregulation
p53
ND3
genes
marked
upregulation
anti-apoptotic
gene
Bcl2.
These
highlight
novel
potent
inducers
death
manner
through
excessive
production,
instability,
dysfunction
expression,
ultimately
promoting
thus
underscores
nanotherapeutic
candidate
treatment,
warranting
further
exploration
elucidate
full
biological
clinical
applicability.
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 13
Published: Jan. 31, 2025
We
develop
and
evaluate
copper-based
metal-organic
frameworks
(Cu-MOFs)
incorporating
cromolyn
as
a
linker
to
enhance
structural
stability,
drug
delivery
efficiency,
therapeutic
potential,
particularly
for
breast
cancer
treatment.
Two
Cu-MOF
formulations
were
synthesized:
Cu-MOFs-BDC-DOX
(using
terephthalic
acid)
Cu-MOFs-CROMO-DOX
linker).
Characterization
was
performed
using
SEM/TEM
morphology,
FTIR,
XRD,
TGA
confirm
integrity.
Drug
encapsulation
efficiency
release
profiles
assessed,
followed
by
in
vitro
cytotoxicity,
cell
migration,
colony
formation
assays
MDA-MB-231
cells.
Both
demonstrated
high
(83-91%)
sustained
over
48
h
at
pH
7.4.
exhibited
superior
cytotoxicity
with
an
IC50
of
0.88
±
0.07
µM
compared
7.1
0.11
Cu-MOFs-BDC-DOX.
inhibit
migration
dose-dependent
manner.
The
formulation
enhanced
outperforming
its
counterpart
targeting
This
study
highlights
the
promise
MOF-based
nanocarriers
overcoming
limitations
conventional
chemotherapy,
offering
pathway
more
effective
targeted
treatments
reduced
side
effects.
Microbial Cell Factories,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 8, 2025
Ecotoxicology
is
essential
for
the
evaluation
and
comprehension
of
effects
emergency
pollutants
(EP)
such
as
heavy
metal
ions
on
natural
environment.
EPs
pose
a
substantial
threat
to
health
humans
proper
functioning
global
ecosystem.
The
primary
concern
exposure
animals
through
contaminated
water.
presence
in
drinking
water
ought
be
monitored
accordance
with
World
Health
Organization
regulations.
Among
numerous
harmful
ions,
copper
are
responsible
variety
human
diseases.
This
study
investigates
application
phage
display
screening
method
toxicological
targets,
served
main
focus.
To
identify
Cu-binding
M13
clones
unique
peptides
assess
their
affinity
utilized
Escherichia
coli
factories
producing
recombinant
bacteriophages,
modified
biopanning
procedure
an
ELISA
assay.
research
highlights
increasing
importance
tool
ecotoxicology.
We
synthesized
selected
peptide
enable
rapid
optical
detection
Cu(II)
aqueous
solutions.
By
incorporating
dansyl
group
into
designated
sequence,
we
implemented
fluorescence
assays
real-time
measurements.
Cu2+-
binding
peptide's
efficacy
was
confirmed
spectroscopic
measurements,
which
allowed
response
times
high
selectivity.
technique
successfully
applied
develop
fluorescent
peptide-based
chemosensor
that
exhibited
selectivity
sensitivity
Cu2+.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 9, 2025
Copper
is
an
essential
micronutrient
involved
in
various
physiological
processes
cell
types.
Consequently,
dysregulation
of
copper
homeostasis-either
excessive
or
deficient-can
lead
to
pathological
changes,
such
as
heart
failure
(HF).
Recently,
a
new
type
copper-dependent
death
known
cuproptosis
has
drawn
increasing
attention
the
impact
dyshomeostasis
on
HF.
Notably,
was
associated
with
occurrence
Hence,
this
review
aimed
investigate
biological
uptake,
transport,
excretion,
and
storage
at
both
cellular
systemic
levels
terms
HF,
along
underlying
mechanisms
action.
Additionally,
role
its
related
mitochondrial
dysfunction
HF
pathogenesis
analyzed.
Finally,
we
reviewed
therapeutic
potential
current
drugs
that
target
metabolism
for
treating
Overall,
conclusions
revealed
copper-based
therapies
development
strategies
treatment
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 19, 2025
Lung
adenocarcinoma
(LUAD)
is
the
most
common
subtype
of
lung
cancer.
Despite
advances
in
treatment,
prognosis
remains
poor
due
to
late
diagnosis.
Cuproptosis
(driven
by
copper
ion
accumulation)
and
disulfidptosis
disulfide
bond
are
novel
forms
programmed
cell
death,
closely
linked
tumor
initiation,
progression,
resistance.
However,
specific
roles
these
mechanisms
LUAD
remain
inadequately
studied.
This
study
integrated
multi-omics
data
from
TCGA
GEO
databases
systematically
evaluate
differential
expression
prognostic
significance
disulfide-related
genes
(DCRGs),
identify
two
DCRG
molecular
subtypes,
construct
a
scoring
model
based
on
four
key
genes.
Multi-omics
analysis
results
revealed
that
score
not
only
accurately
predicts
patients
but
also
associated
with
immune
infiltration
patterns
EGFR
inhibitor
responses.
RT-qPCR
validated
high
FURIN
RHOV
cells,
supporting
their
role
as
potential
therapeutic
targets.
Further
Mendelian
randomization
confirmed
causal
relationship
between
development.
These
findings
provide
biomarkers
for
evaluation
cuproptosis
offer
theoretical
basis
targeting
treatment.
