Actual Data on Essential Trace Elements in Parkinson’s Disease DOI Open Access
Cristina Popescu, Constantin Munteanu, Aura Spînu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(11), P. 1852 - 1852

Published: May 29, 2025

“Sola dosis facit venenum” (Paracelsus). Essential trace elements, crucial for maintaining neuronal function, have their dysregulation increasingly correlated with neurodegenerative disorders, particularly Parkinson’s disease (PD). This systematic review aims to synthesize recent high-quality evidence regarding the involvement of essential such as iron, zinc, copper, manganese, and selenium, in pathogenesis and, consequently, potential therapeutic targets PD. A comprehensive literature search was conducted articles published between 1 January 2023 31 December 2024. Out an initial pool 1231 identified studies, 63 met methodological eligibility criteria according PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) guidelines. All potentially eligible interventional observational studies were initially assessed using Physiotherapy Evidence Database (PEDro) scale, which is commonly employed evaluating internal validity statistical interpretability clinical trials rehabilitation-focused studies. Following qualitative assessment PEDro 18 ultimately selected based on scientific relevance rigor. To supplement scoring, designed primarily individual trials, we applied AMSTAR-2 (A MeaSurement Tool Assess Reviews) checklist evaluation included reviews or meta-analyses. The a variety clinical, postmortem, experimental models investigate trace-element concentrations mechanistic roles findings revealed consistent patterns iron accumulation substantia nigra, zinc’s bidirectional effects oxidative stress autophagy, copper-induced α-synuclein aggregation, neuroprotective role selenium via antioxidant pathways. Manganese associated mitochondrial dysfunction neuroinflammation. disturbances contribute PD pathology through interconnected mechanisms involving redox imbalance, protein misfolding, impaired cellular homeostasis. These elements may serve both biomarkers tools, warranting further investigation into personalized metal-based interventions

Language: Английский

lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer DOI Creative Commons
Asif Ahmad Bhat, Muhammad Afzal, Ehssan Moglad

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Language: Английский

Citations

14
Copper in melanoma: at the crossroad of protumorigenic and anticancer roles DOI Creative Commons

Natalia Chrzan,

Mariusz L. Hartman

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103552 - 103552

Published: Feb. 15, 2025

Language: Английский

Citations

2
Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells DOI Creative Commons
Hanan R. H. Mohamed,

Basma A. Mohamed,

George M. Hakeem

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

Nanotherapy has emerged as a promising strategy for the targeted and efficient treatment of melanoma, most aggressive lethal form skin cancer, with minimized systemic toxicity. However, therapeutic efficacy cobalt oxide nanoparticles (Co3O4NPs) in melanoma remains unexplored. This study aimed to assess potential Co3O4NPs by evaluating their impact on cell viability, genomic DNA mitochondrial integrity, reactive oxygen species (ROS) generation apoptosis induction A-375 cells. Our findings demonstrated concentration-dependent reduction viability upon five Co3O4NP concentrations (0.2, 2, 20, 200, 2000 µg/ml), an IC50 value 303.80 µg/ml. Treatment this concentration significantly increased ROS generation, induced dramatic damage, disrupted membrane integrity. Flow cytometric analysis revealed necrosis following exposure at value. Results qRT-PCR remarkable dysregulation apoptotic genes, including significant downregulation p53 ND3 genes marked upregulation anti-apoptotic gene Bcl2. These highlight novel potent inducers death manner through excessive production, instability, dysfunction expression, ultimately promoting thus underscores nanotherapeutic candidate treatment, warranting further exploration elucidate full biological clinical applicability.

Language: Английский

Citations

1
Formation and evaluation of doxorubicin and cromoglycate metal–organic framework for anti-cancer activity DOI

Ebaa Abu Saleem,

Zainab Lafi, Naeem Shalan

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Jan. 31, 2025

We develop and evaluate copper-based metal-organic frameworks (Cu-MOFs) incorporating cromolyn as a linker to enhance structural stability, drug delivery efficiency, therapeutic potential, particularly for breast cancer treatment. Two Cu-MOF formulations were synthesized: Cu-MOFs-BDC-DOX (using terephthalic acid) Cu-MOFs-CROMO-DOX linker). Characterization was performed using SEM/TEM morphology, FTIR, XRD, TGA confirm integrity. Drug encapsulation efficiency release profiles assessed, followed by in vitro cytotoxicity, cell migration, colony formation assays MDA-MB-231 cells. Both demonstrated high (83-91%) sustained over 48 h at pH 7.4. exhibited superior cytotoxicity with an IC50 of 0.88 ± 0.07 µM compared 7.1 0.11 Cu-MOFs-BDC-DOX. inhibit migration dose-dependent manner. The formulation enhanced outperforming its counterpart targeting This study highlights the promise MOF-based nanocarriers overcoming limitations conventional chemotherapy, offering pathway more effective targeted treatments reduced side effects.

Language: Английский

Citations

1
Synthesis, characterization, crystal structures, and toxicity studies of nitro-lawsone, its oxime derivative, and Cu(II) complexes DOI

Manisha Gaikwad,

Sunita Salunke‐Gawali, Vivek Mokashi

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142195 - 142195

Published: March 1, 2025

Language: Английский

Citations

1
Phage display technology in ecotoxicology: phage display derived unique peptide for copper identification in aquatic samples DOI Creative Commons
Marta Sosnowska, Tomasz Łęga, Marcin Olszewski

et al.

Microbial Cell Factories, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 8, 2025

Ecotoxicology is essential for the evaluation and comprehension of effects emergency pollutants (EP) such as heavy metal ions on natural environment. EPs pose a substantial threat to health humans proper functioning global ecosystem. The primary concern exposure animals through contaminated water. presence in drinking water ought be monitored accordance with World Health Organization regulations. Among numerous harmful ions, copper are responsible variety human diseases. This study investigates application phage display screening method toxicological targets, served main focus. To identify Cu-binding M13 clones unique peptides assess their affinity utilized Escherichia coli factories producing recombinant bacteriophages, modified biopanning procedure an ELISA assay. research highlights increasing importance tool ecotoxicology. We synthesized selected peptide enable rapid optical detection Cu(II) aqueous solutions. By incorporating dansyl group into designated sequence, we implemented fluorescence assays real-time measurements. Cu2+- binding peptide's efficacy was confirmed spectroscopic measurements, which allowed response times high selectivity. technique successfully applied develop fluorescent peptide-based chemosensor that exhibited selectivity sensitivity Cu2+.

Language: Английский

Citations

0
Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies DOI Creative Commons
Zhichao Liu,

Yongkang Gan,

Zhen Shen

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Copper is an essential micronutrient involved in various physiological processes cell types. Consequently, dysregulation of copper homeostasis-either excessive or deficient-can lead to pathological changes, such as heart failure (HF). Recently, a new type copper-dependent death known cuproptosis has drawn increasing attention the impact dyshomeostasis on HF. Notably, was associated with occurrence Hence, this review aimed investigate biological uptake, transport, excretion, and storage at both cellular systemic levels terms HF, along underlying mechanisms action. Additionally, role its related mitochondrial dysfunction HF pathogenesis analyzed. Finally, we reviewed therapeutic potential current drugs that target metabolism for treating Overall, conclusions revealed copper-based therapies development strategies treatment

Language: Английский

Citations

0
A prognostic model for lung adenocarcinoma based on cuproptosis and disulfidptosis related genes revealing the key prognostic role of FURIN DOI Creative Commons
Ji Young You,

Qing Yu,

Ronghui Chen

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 19, 2025

Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer. Despite advances in treatment, prognosis remains poor due to late diagnosis. Cuproptosis (driven by copper ion accumulation) and disulfidptosis disulfide bond are novel forms programmed cell death, closely linked tumor initiation, progression, resistance. However, specific roles these mechanisms LUAD remain inadequately studied. This study integrated multi-omics data from TCGA GEO databases systematically evaluate differential expression prognostic significance disulfide-related genes (DCRGs), identify two DCRG molecular subtypes, construct a scoring model based on four key genes. Multi-omics analysis results revealed that score not only accurately predicts patients but also associated with immune infiltration patterns EGFR inhibitor responses. RT-qPCR validated high FURIN RHOV cells, supporting their role as potential therapeutic targets. Further Mendelian randomization confirmed causal relationship between development. These findings provide biomarkers for evaluation cuproptosis offer theoretical basis targeting treatment.

Language: Английский

Citations

0
Unravelling the developmental toxicity of heavy metals using zebrafish as a model: a narrative review DOI
Soumen K. Manna, Sayeed Mohammed Firdous

BioMetals, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Language: Английский

Citations

0
N,N’bis-(2-mercaptoethyl) isophthalamide (NBMI) as a novel chelator for Wilson’s Disease DOI
Rajitha Gadde, Shrey Shah,

Mark Böhlke

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0