Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 257, P. 112578 - 112578
Published: April 25, 2024
Language: Английский
Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142356 - 142356
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118444 - 118444
Published: June 6, 2024
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6487 - 6487
Published: June 12, 2024
Copper is a transition metal essential for growth and development indispensable eukaryotic life. This to neuronal function: its deficiency, as well overload have been associated with multiple neurodegenerative disorders such Alzheimer's disease Wilson's psychiatric conditions schizophrenia, bipolar disorder, major depressive disorders. plays fundamental role in the function of human Central Nervous System (CNS), being cofactor enzymes that play key physiology during development. In this context, we thought it would be timely summarize data on alterations metabolism copper at CNS level might influence neuropsychiatric symptoms. We present non-systematic review study selection based authors' judgement offer reader perspective most significant elements symptoms disease. highlight characterized by marked heterogeneity clinical presentation among patients same mutation. should motivate more research efforts disentangle environmental factors modulating expression genetic predisposition disorder.
Language: Английский
Citations
3
Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107279 - 107279
Published: June 26, 2024
Transfer RNA-derived small RNAs (tsRNAs) are a class of non-coding RNA (sncRNA) molecules derived from tRNA, including tRNA fragments (tRFs) and halfs (tiRNAs). tsRNAs can affect cell functions by participating in gene expression regulation, translation intercellular signal transduction, immune response. They have been shown to play an important role various human diseases, cardiovascular diseases (CVDs). Targeted regulation the progression CVDs. The induced pathological conditions be detected when released into extracellular, giving them enormous potential as disease biomarkers. Here, we review biogenesis, degradation process related functional mechanisms tsRNAs, discuss research progress application prospects different CVDs, provide new perspective on treatment
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7545 - 7545
Published: July 9, 2024
Wilson's disease (WD) is inherited in an autosomal recessive manner and caused by pathogenic variants of the
Language: Английский
Citations
2
Current Medical Science, Journal Year: 2024, Volume and Issue: 44(5), P. 867 - 882
Published: Sept. 30, 2024
Language: Английский
Citations
2
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: March 22, 2024
Phosphatase and tensin homologue deleted on chromosome ten (PTEN) was initially recognized as a significant regulator of cancer suppression could impede cell survival, proliferation, energy metabolism. PTEN is highly expressed in neurons performs crucial functions neurogenesis, synaptogenesis, neuronal survival. Disruption activity may also result abnormal function associated with various neurological disorders, including stroke, seizures, autism. Although several studies have shown that involved the development degenerative processes nervous system, there still lack in-depth summarize analyse patterns cooperation between authors, institutions, countries, journals, well research hotspots trends this important field. To identify further visualize comprehend especially neural diseases, we used bibliometric analysis to relevant publications topic. We first found number displayed growing trend time, but not stable. Universities, authors from United States are leading area research. In addition, many cutting-edge results been discovered, such key regulatory molecules cellular mechanisms which provide novel intervention targets precise therapeutic strategies for related pathological injuries diseases. Finally, literature published within last 5 years discussed future regarding system. Taken together, our findings, analysed using bibliometrics, reflect trends, providing reference studying These findings can assist new researchers developing their interests gaining basic information. Moreover, clinical guidelines treating system diseases caused by dysfunction.
Language: Английский
Citations
1
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: July 9, 2024
Citation: Li J, Wang Y, Xiong K and Gao C (2024) Editorial: Neuroinflammation cognitive impairment. Front. Aging Neurosci. 16:1453772. doi: 10.3389/fnagi.2024.1453772
Citations
1
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 16, 2024
Objectives Osteosarcoma (OS) is the primary bone tumor originating from transformed mesenchymal cells. It unclear whether associations between specific circulating immune cells and OS are causal or due to bias. To clarify predicted genetically altered associated with development, we performed a two-sample Mendelian randomization (MR) analysis. Methods The genetic variants strongly cell traits as instrumental variables (IVs) were used perform MR analyses. effect of on risk was measured using summary statistics genome-wide association studies (GWAS). Results Our findings indicate that CD80 CD62L+ myeloid dendritic CD28−CD4−CD8− T-cell absolute count positively (CD80 cell, OR: 3.41 [95% CI: 1.40 8.31], p = 0.007; count, 4.49 1.29 15.62], 0.018). also found CD20 has negative CD24+CD27+ B (OR: 0.32 0.14 0.72], 0.006) similar impact IgD+ CD38− 0.19 0.05 0.68], 0.011). Conclusions These illustrate predisposition can exert risk, which confirms crucial role played by immunity in development. Particularly, underscores evidence for exploring new treatment strategy future.
Language: Английский
Citations
1
World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(8), P. 773 - 779
Published: Aug. 26, 2024
In this editorial, we delved into the article titled “Cellular preconditioning and mesenchymal stem cell ferroptosis.” This groundbreaking study underscores a pivotal discovery: Ferroptosis, type of programmed death, drastically reduces viability donor cells (MSCs) after engraftment, thereby undermining therapeutic value cell-based therapies. Furthermore, proposes that by manipulating ferroptosis mechanisms through preconditioning, can potentially enhance survival rate functionality MSCs, ultimately amplifying their potential. Given crucial role plays in shaping outcomes deem it imperative to further investigate intricate interplay between death effectiveness MSCs.
Language: Английский
Citations
1