Glymphatic system dysfunction in cerebral infarction: advances and perspectives based on DTI-derived ALPS measures DOI
Bo Lin,

Y Y Leong,

Mazlyfarina Mohamad

et al.

American Journal of Translational Research, Journal Year: 2025, Volume and Issue: 17(3), P. 1630 - 1642

Published: Jan. 1, 2025

The glymphatic pathway plays a crucial role in the clearance of metabolic byproducts and solutes from cerebral tissue. Dysfunction has been associated with various neurological disorders, including ischemic stroke. Diffusion tensor imaging (DTI) derived Analysis aLong Perivascular Space (ALPS) have emerged as promising tools for evaluating function. This review aims to summarize current evidence on use DTI-derived ALPS measures assessing dysfunction stroke patients, explore their potential implications diagnosis, prognostication, treatment monitoring this patient population.

Language: Английский

Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements DOI
Adam M. Wright, Yu‐Chien Wu, Li Feng

et al.

NMR in Biomedicine, Journal Year: 2024, Volume and Issue: 37(9)

Published: May 7, 2024

Abstract Cerebrospinal fluid (CSF) plays a critical role in metabolic waste clearance from the brain, requiring its circulation throughout various brain pathways, including ventricular system, subarachnoid spaces, para‐arterial interstitial and para‐venous spaces. The complexity of CSF has posed challenge obtaining noninvasive measurements dynamics. assessment dynamics circulatory pathways is possible using diffusion magnetic resonance imaging (MRI) with optimized sensitivity to incoherent water movement across brain. This review presents an overview both established emerging MRI techniques designed measure their potential clinical applications. discussion offers insights into optimization acquisition parameters enhance specificity metrics on underlying Lastly, we emphasize importance cautious interpretations diffusion‐based imaging, especially when differentiating between tissue‐ fluid‐related changes or elucidating structural versus functional alterations.

Language: Английский

Citations

13
Glymphatic system dysfunction in middle-aged and elderly chronic insomnia patients with cognitive impairment evidenced by diffusion tensor imaging along the perivascular space (DTI-ALPS) DOI

Yu Jin,

Wenmin Zhang, M. C. Yu

et al.

Sleep Medicine, Journal Year: 2024, Volume and Issue: 115, P. 145 - 151

Published: Feb. 6, 2024

Language: Английский

Citations

11
Widespread and Prolonged Pain May Reduce Brain Clearance Capacity Only via Sleep Impairment: Evidence from Participants with Knee Pain DOI
Pedro A. Valdés-Hernández, Soamy Montesino-Goicolea, Chavier Laffitte Nodarse

et al.

Journal of Pain, Journal Year: 2025, Volume and Issue: unknown, P. 105356 - 105356

Published: March 1, 2025

Language: Английский

Citations

1
Noninvasive Magnetic Resonance Imaging Measures of Glymphatic System Activity DOI Creative Commons
Koji Kamagata, Yuya Saito, Christina Andica

et al.

Journal of Magnetic Resonance Imaging, Journal Year: 2023, Volume and Issue: 59(5), P. 1476 - 1493

Published: Sept. 1, 2023

The comprehension of the glymphatic system, a postulated mechanism responsible for removal interstitial solutes within central nervous system (CNS), has witnessed substantial progress recently. While direct measurement techniques involving fluorescence and contrast agent tracers have demonstrated success in animal studies, their application humans is invasive presents challenges. Hence, exploring alternative noninvasive approaches that enable research imperative. This review primarily focuses on several magnetic resonance imaging (MRI) techniques, encompassing perivascular space (PVS) imaging, diffusion tensor image analysis along PVS, arterial spin labeling, chemical exchange saturation transfer, intravoxel incoherent motion. These methodologies provide valuable insights into dynamics fluid, water permeability across blood-brain barrier, cerebrospinal fluid flow cerebral parenchyma. Furthermore, elucidates underlying concept clinical applications these MRI highlighting strengths limitations. It addresses concerns about relationship between activity pathological alterations, emphasizing necessity further studies to establish correlations measurements findings. Additionally, challenges associated with conducting multisite such as variability systems acquisition parameters, are addressed, suggestion use harmonization methods, combined association test (COMBAT), enhance standardization statistical power. Current gaps future directions assessing discussed, need larger sample sizes, approaches. In conclusion, this provides invaluable methods monitoring CNS. highlights potential advancing our understanding facilitating applications, paving way endeavors field. EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: Stage 5.

Language: Английский

Citations

21
Neurofluids and the glymphatic system: anatomy, physiology, and imaging DOI Creative Commons
Danny J.J. Wang, Jun Hua, Di Cao

et al.

British Journal of Radiology, Journal Year: 2023, Volume and Issue: 96(1151)

Published: May 16, 2023

First described in 2012, the glymphatic system is responsible for maintaining homeostasis within central nervous system, including nutrient delivery, waste clearance, and consistency of ionic microenvironment. It comprised glial cells barrier systems that modulate neurofluid production, circulation, exchange. Experimental interrogation dynamics restricted to

Language: Английский

Citations

17
Current State of Artificial Intelligence in Clinical Applications for Head and Neck MR Imaging DOI Creative Commons
Noriyuki Fujima, Koji Kamagata, Daiju Ueda

et al.

Magnetic Resonance in Medical Sciences, Journal Year: 2023, Volume and Issue: 22(4), P. 401 - 414

Published: Jan. 1, 2023

Due primarily to the excellent soft tissue contrast depictions provided by MRI, widespread application of head and neck MRI in clinical practice serves assess various diseases. Artificial intelligence (AI)-based methodologies, particularly deep learning analyses using convolutional neural networks, have recently gained global recognition been extensively investigated research for their applicability across a range categories within medical imaging, including MRI. Analytical approaches AI shown potential addressing limitations associated with In this review, we focus on technical advancements deep-learning-based methodologies utility field encompassing aspects such as image acquisition reconstruction, lesion segmentation, disease classification diagnosis, prognostic prediction patients presenting We then discuss current offer insights regarding future challenges field.

Language: Английский

Citations

17
Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index: an analysis of reorientation technique of the OASIS-3 dataset DOI Creative Commons
Hiroyuki Tatekawa, Shu Matsushita, Daiju Ueda

et al.

Japanese Journal of Radiology, Journal Year: 2022, Volume and Issue: 41(4), P. 393 - 400

Published: Dec. 6, 2022

Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is intended to reflect glymphatic function of brain; however, head rotation may reduce reproducibility and reliability. This study aimed evaluate whether reorientation DTI data improves ALPS using OASIS-3 dataset.234 cognitively normal subjects from dataset were included. Original reoriented indices calculated a technique that registered vector information another created diffusivity maps. The F test was used compare variances original indices. Subsequently, with around z- (inferior-superior; n = 43) or x axis (right-left; 25) matched neutral position selected for evaluation intra- inter-rater Intraclass correlation coefficients (ICCs) participants separately. Bland-Altman plot comparing also evaluated.The exhibited significantly smaller variance than (p < 0.001). For inter-reliability, showed good-to-excellent in calculating even (ICCs index: 0.52-0.81; ICCs > 0.85). A wider range 95% limit agreement identified, indicating remarkably affect calculation index.The this enabled creation maps improved index.

Language: Английский

Citations

27
Glymphatic system dysfunction in pediatric acute lymphoblastic leukemia without clinically diagnosed central nervous system infiltration: a novel DTI-ALPS method DOI

Liping Lin,

Shu Su,

Weifeng Hou

et al.

European Radiology, Journal Year: 2023, Volume and Issue: 33(5), P. 3726 - 3734

Published: March 8, 2023

Language: Английский

Citations

13
Interstitial Fluidopathy of the Central Nervous System: An Umbrella Term for Disorders with Impaired Neurofluid Dynamics DOI Creative Commons
Toshiaki Taoka, Rintaro Ito, Rei Nakamichi

et al.

Magnetic Resonance in Medical Sciences, Journal Year: 2022, Volume and Issue: 23(1), P. 1 - 13

Published: Nov. 24, 2022

Interest in interstitial fluid dynamics has increased since the proposal of glymphatic system hypothesis. Abnormal have been pointed out to be an important factor various pathological statuses. In this article, we propose concept central nervous fluidopathy as a disease or condition which abnormal is one factors for development condition. We discuss aspects diseases, including Alzheimer's disease, Parkinson's normal pressure hydrocephalus, and cerebral small vessel disease. also method called "diffusion tensor image analysis along perivascular space" using MR diffusion images, used evaluate degree activity system.

Language: Английский

Citations

18
Recent Advances in Assessing Glymphatic System Function in Neurological Diseases Based on DTI-ALPS Method DOI Creative Commons

禹婷 蒋

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 98 - 108

Published: Jan. 1, 2025

Language: Английский

Citations

0