Journal of Vacuum Science & Technology B Nanotechnology and Microelectronics Materials Processing Measurement and Phenomena,
Journal Year:
2024,
Volume and Issue:
42(2)
Published: Feb. 13, 2024
The
prevalence
of
breast
cancer
in
women
underscores
the
urgent
need
for
innovative
and
efficient
detection
methods.
This
study
addresses
this
imperative
by
harnessing
salivary
biomarkers,
offering
a
noninvasive
accessible
means
identifying
cancer.
In
study,
commercially
available
disposable
based
strips
similar
to
commonly
used
glucose
were
utilized
functionalized
detect
with
biomarkers
HER2
CA15-3.
results
demonstrated
limits
these
two
reached
as
low
1
fg/ml
much
lower
than
those
conventional
enzyme-linked
immunosorbent
assay
range
1∼4
ng/ml.
By
employing
synchronized
double-pulse
method
apply
10
1.2
ms
voltage
pulses
electrode
sensing
strip
drain
transistor
amplifying
detected
signal,
signal
was
average
digital
output
readings
corresponding
pulses.
sensor
sensitivities
achieved
approximately
70/dec
30/dec
CA15-3,
respectively.
Moreover,
efficiency
novel
technique
is
underscored
its
swift
testing
time
less
15
minimal
sample
requirement
only
3
Biosensors,
Journal Year:
2021,
Volume and Issue:
11(6), P. 179 - 179
Published: June 3, 2021
Neurotransmitters
are
biochemical
molecules
that
transmit
a
signal
from
neuron
across
the
synapse
to
target
cell,
thus
being
essential
function
of
central
and
peripheral
nervous
system.
Dopamine
is
one
most
important
catecholamine
neurotransmitters
since
it
involved
in
many
functions
human
system,
including
motor
control,
reward,
or
reinforcement.
It
utmost
importance
quantify
amount
dopamine
abnormal
levels
can
cause
variety
medical
behavioral
problems.
For
instance,
Parkinson’s
disease
partially
caused
by
death
dopamine-secreting
neurons.
To
date,
various
methods
have
been
developed
measure
levels,
electrochemical
biosensing
seems
be
viable
due
its
robustness,
selectivity,
sensitivity,
possibility
achieve
real-time
measurements.
Even
if
detection
not
facile
presence
electroactive
interfering
species
with
similar
redox
potentials
real
biological
samples,
numerous
strategies
employed
resolve
this
issue.
The
objective
paper
review
materials
(metals
metal
oxides,
carbon
materials,
polymers)
frequently
used
for
point
out
their
respective
advantages
drawbacks.
Different
types
biosensors,
(micro)electrodes,
platforms,
field-effect
transistors,
also
described.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(19), P. 11488 - 11558
Published: Sept. 25, 2023
The
eye
contains
a
complex
network
of
physiological
information
and
biomarkers
for
monitoring
disease
managing
health,
ocular
devices
can
be
used
to
effectively
perform
point-of-care
diagnosis
management.
This
comprehensive
review
describes
the
target
various
diseases,
including
ophthalmic
metabolic
neurological
based
on
anatomical
background
eye.
also
includes
recent
technologies
utilized
in
eye-wearable
medical
latest
trends
wearable
devices,
specifically
smart
contact
lenses
purpose
After
introducing
other
such
as
retinal
prosthesis,
we
further
discuss
current
challenges
potential
possibilities
lenses.
International Journal of Nanomedicine,
Journal Year:
2021,
Volume and Issue:
Volume 16, P. 803 - 832
Published: Feb. 1, 2021
Abstract:
Heavy
metals
cause
considerable
environmental
pollution
due
to
their
extent
and
non-degradability
in
the
environment.
Analysis
trace
levels
of
arsenic,
lead,
mercury,
cadmium
as
most
toxic
heavy
show
that
they
can
various
hazards
humans'
health.
To
achieve
rapid,
high-sensitivity
methods
for
analyzing
ultra-trace
amounts
different
biological
samples,
novel
biosensors
have
been
designed
with
participation
strategies
applied
nanotechnology.
This
review
attempted
investigate
novel,
sensitive,
efficient,
cost-benefit,
point
care,
user-friendly
detect
these
based
on
functional
mechanisms.
The
study's
search
included
examining
primary
databases
from
2015
onwards
keywords
focusing
metal
biosensors'
performance
toxicity
use
aptamers
whole
cells
two
important
bio-functional
nanomaterials
is
remarkable
diagnostic
bioreceptor
design.
application
hybridized
containing
a
specific
physicochemical
function
presence
suitable
transducer
improve
sensing
an
integrated
detection
system.
Our
study
showed
addition
both
labeled
label-free
strategies,
wide
range
nanoparticles
nanocomposites
were
used
modify
biosensor
surface
platform
metals.
limit
linear
dynamic
essential
characteristic
superior
are
studied.
Furthermore,
perspectives
challenges
facing
design
outlined.
development
nanotechnology,
especially
real
face
such
capability
simultaneously
multiple
metals,
interference
process
complex
matrices,
efficiency
stability
implemented
laboratory
conditions.
Keywords:
biosensors,
toxicity,
nanomaterials,
ACS Applied Materials & Interfaces,
Journal Year:
2020,
Volume and Issue:
13(8), P. 9329 - 9358
Published: Nov. 6, 2020
Aptamers
are
exciting
smart
molecular
probes
for
specific
recognition
of
disease
biomarkers.
A
number
strategies
have
been
developed
to
convert
target–aptamer
binding
into
physically
detectable
signals.
Since
the
aptamer
sequence
was
first
discovered,
a
large
variety
aptamer-based
biosensors
developed,
with
considerable
attention
paid
their
potential
applications
in
clinical
diagnostics.
So
far,
techniques
combination
wide
range
functional
nanomaterials
used
design
aptasensors
further
improve
sensitivity
and
detection
limit
target
determination.
In
this
paper,
advantages
aptamers
over
traditional
antibodies
as
components
high-throughput
screening
molecules
highlighted.
Aptamer–target
pairing
configurations
predominantly
single-
or
dual-site
binding;
modes
each
aptamer–target
configuration
is
described.
Furthermore,
signal
transduction
including
optical,
electrical,
mechanical,
mass-sensitive
clearly
explained
together
examples.
Finally,
we
summarize
recent
progress
development
diagnosis,
cancer
biomarkers
vivo
imaging.
We
then
conclude
discussion
on
advanced
challenges
aptasensors.
Biosensors,
Journal Year:
2022,
Volume and Issue:
12(5), P. 269 - 269
Published: April 24, 2022
Cancer
is
one
of
the
deadliest
diseases
worldwide,
and
there
a
critical
need
for
diagnostic
platforms
applications
in
early
cancer
detection.
The
diagnosis
can
be
made
by
identifying
abnormal
cell
characteristics
such
as
functional
changes,
number
vital
proteins
body,
genetic
mutations
structural
so
on.
Identifying
biomarker
candidates
DNA,
RNA,
mRNA,
aptamers,
metabolomic
biomolecules,
enzymes,
most
important
challenges.
In
order
to
eliminate
challenges,
emerging
biomarkers
identified
designing
suitable
biosensor.
One
powerful
technologies
development
biosensor
technology
based
on
nanostructures.
Recently,
graphene
its
derivatives
have
been
used
diverse
therapeutic
approaches.
Graphene-based
biosensors
exhibited
significant
performance
with
excellent
sensitivity,
selectivity,
stability,
wide
detection
range.
this
review,
principle
technology,
advances,
challenges
graphene-based
field-effect
transistors
(FET),
fluorescence
sensors,
SPR
biosensors,
electrochemical
detect
different
cells
systematically
discussed.
Additionally,
we
provide
an
outlook
properties,
applications,
derivatives,
Graphene
Oxide
(GO),
Reduced
(RGO),
Quantum
Dots
(GQDs),
nanobiosensors.
