Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 192, P. 114636 - 114636
Published: Dec. 6, 2022
Language: Английский
Diagnostics, Journal Year: 2023, Volume and Issue: 13(8), P. 1375 - 1375
Published: April 8, 2023
Förster resonance energy transfer (FRET)-based biosensors are being fabricated for specific detection of biomolecules or changes in the microenvironment. FRET is a non-radiative from an excited donor fluorophore molecule to nearby acceptor molecule. In FRET-based biosensor, and molecules typically fluorescent proteins nanomaterials such as quantum dots (QDs) small that engineered be close proximity each other. When biomolecule interest present, it can cause change distance between acceptor, leading efficiency corresponding fluorescence intensity acceptor. This used detect quantify interest. have wide range applications, including fields biochemistry, cell biology, drug discovery. review article provides substantial approach on principle, applications point-of-need diagnosis, wearable, single molecular (smFRET), hard water, ions, pH, tissue-based sensors, immunosensors, aptasensor. Recent advances artificial intelligence (AI) Internet Things (IoT) this type sensor challenges.
Language: Английский
Citations
73
Carbon, Journal Year: 2023, Volume and Issue: 213, P. 118281 - 118281
Published: July 5, 2023
Language: Английский
Citations
57
Biosensors, Journal Year: 2024, Volume and Issue: 14(6), P. 277 - 277
Published: May 28, 2024
Biosensors function as sophisticated devices, converting biochemical reactions into electrical signals. Contemporary emphasis on developing biosensor devices with refined sensitivity and selectivity is critical due to their extensive functional capabilities. However, a significant challenge lies in the binding affinity of biosensors biomolecules, requiring adept conversion amplification interactions various signal modalities like electrical, optical, gravimetric, electrochemical outputs. Overcoming challenges associated sensitivity, detection limits, response time, reproducibility, stability essential for efficient creation. The central aspect fabrication any focused towards forming an effective interface between analyte electrode which significantly influences overall quality. Polymers macromolecular systems are favored distinct properties versatile applications. Enhancing conductivity these can be achieved through incorporating nanoparticles or carbonaceous moieties. Hybrid composite materials, possessing unique combination attributes advanced selectivity, thermal stability, mechanical flexibility, biocompatibility, tunable properties, emerge promising candidates In addition, this approach enhances response, amplification, fabricated biosensors, contributing effectiveness. This review predominantly explores recent advancements utilizing macrocyclic conjugated systems, such phthalocyanines, porphyrins, polymers, etc. hybrids, specific focus biosensors. It comprehensively covers synthetic strategies, working mechanisms, potential detecting biomolecules glucose, hydrogen peroxide, uric acid, ascorbic dopamine, cholesterol, amino acids, cancer cells. Furthermore, delves progress made, elucidating mechanisms responsible amplification. Conclusion addresses future directions macromolecule-based hybrids applications, providing concise overview evolving field. narrative emphasizes importance technology advancement, illustrating role smart design material enhancement improving performance across domains.
Language: Английский
Citations
29
ECS Sensors Plus, Journal Year: 2024, Volume and Issue: 3(2), P. 020601 - 020601
Published: April 1, 2024
Dopamine is an essential neurotransmitter for daily cognitive functions controlling many neurophysiological processes including memory, cognition, and physical control. Development of analytical methods sensors to detect dopamine important health monitoring neurological research. This review provides overview recent advances in the development electrochemical catalytic biosensors based on enzyme enzyme-mimetic materials discusses their potential applications measurements biological fluids. The first part summarizes critically assesses different types enzymes mimetic that can be used catalytically convert dopamine, followed by a discussion biosensor’s fabrication, key design parameters, detection mechanism various electrode platforms ranging from single-use screen-printed electrodes microneedles implantable microelectrodes. second examples samples, saliva, urine, serum, cell cultures, brain tissue. We conclude with summary advantages limitations these devices clinical field, outlook future research towards implementation broader adoption neurophysiology, pharmacology, field.
Language: Английский
Citations
20
Applied Surface Science, Journal Year: 2022, Volume and Issue: 592, P. 153257 - 153257
Published: April 2, 2022
Language: Английский
Citations
51
Biosensors, Journal Year: 2023, Volume and Issue: 13(2), P. 211 - 211
Published: Jan. 31, 2023
Catecholamines, including dopamine, epinephrine, and norepinephrine, are considered one of the most crucial subgroups neurotransmitters in central nervous system (CNS), which they act at brain’s highest levels mental function play key roles neurological disorders. Accordingly, analysis such catecholamines biological samples has shown a great interest clinical pharmaceutical importance toward early diagnosis diseases as Epilepsy, Parkinson, Alzheimer diseases. As promising routes for real-time monitoring catecholamine neurotransmitters, optical electrochemical biosensors have been widely adopted perceived dramatically accelerating development last decade. Therefore, this review aims to provide comprehensive overview on recent advances main challenges biosensors. Particular emphasis is given biosensors, reviewing their sensing mechanism unique characteristics brought by emergence nanotechnology. Based specific biosensors’ performance metrics, multiple perspectives therapeutic use nanomaterial future trends also summarized.
Language: Английский
Citations
39
Chemosensors, Journal Year: 2023, Volume and Issue: 11(3), P. 179 - 179
Published: March 7, 2023
Neurotransmitters (NTs) are known as endogenous chemical messengers with important roles in the normal functioning of central and peripheral nervous systems. Abnormal levels certain NTs, such dopamine, serotonin epinephrine, have been linked several neurodegenerative diseases (such Alzheimer’s disease, Parkinson’s disease Huntington’s disease). To date, various strategies employed for quantitative determination nanocomposite materials based on conducting polymers metal nanoparticles constitute a cornerstone development electrochemical sensors low costs, stability, fast response rates high selectivity sensitivity. The preparation analytical applications sensing neurotransmitters discussed this paper. Recent developments also emphasis benefits brought by improving sensitivity measurements. synthesis methods situ generation within polymer layers reviewed. nanocomposite-sensing towards detection epinephrine terms quantification limits, linear range, selectivity.
Language: Английский
Citations
30
Clinica Chimica Acta, Journal Year: 2023, Volume and Issue: 547, P. 117437 - 117437
Published: June 13, 2023
Language: Английский
Citations
24
Journal of Electroanalytical Chemistry, Journal Year: 2024, Volume and Issue: 959, P. 118180 - 118180
Published: March 12, 2024
Language: Английский
Citations
10
Bulletin of Materials Science, Journal Year: 2024, Volume and Issue: 47(2)
Published: March 23, 2024
Language: Английский
Citations
9