Scientific Reports,
Journal Year:
2019,
Volume and Issue:
9(1)
Published: July 29, 2019
Abstract
Bariatric
surgery
in
morbid
obesity,
either
through
sleeve
gastrectomy
(SG)
or
Roux-Y
gastric
bypass
(RYGB),
leads
to
sustainable
weight
loss,
improvement
of
metabolic
disorders
and
changes
intestinal
microbiota.
Yet,
the
relationship
between
gut
microbiota,
loss
surgical
procedure
remains
incompletely
understood.
We
determined
temporal
microbiota
composition
45
obese
patients
undergoing
crash
diet
followed
by
SG
(
n
=
22)
RYGB
23).
Intestinal
was
before
intervention
(baseline,
S1),
2
weeks
after
(S2),
1
week
(S3),
3
months
(S4)
6
(S5)
surgery.
Relative
S1,
microbial
diversity
index
declined
at
S2
S3
p
<
0.05),
gradually
returned
baseline
levels
S5.
Rikenellaceae
relative
abundance
increased
Ruminococcaceae
Streptococcaceae
decreased
0.05).
At
S3,
Bifidobacteriaceae
decreased,
whereas
those
Enterobacteriaceae
Increased
S3-S5
not
associated
with
major
composition.
No
significant
differences
appeared
both
procedures.
In
conclusion,
a
bariatric
were
an
immediate
but
temporary
decline
diversity,
permanent
composition,
independent
type.
EBioMedicine,
Journal Year:
2020,
Volume and Issue:
51, P. 102590 - 102590
Published: Jan. 1, 2020
A
substantial
body
of
literature
has
provided
evidence
for
the
role
gut
microbiota
in
metabolic
diseases
including
type
2
diabetes.
However,
reports
vary
regarding
association
particular
taxonomic
groups
with
disease.
In
this
systematic
review,
we
focused
on
potential
different
bacterial
taxa
affecting
We
have
summarized
from
42
human
studies
reporting
microbial
associations
disease,
and
identified
supporting
preclinical
or
clinical
trials
using
treatments
probiotics.
Among
commonly
reported
findings,
genera
Bifidobacterium,
Bacteroides,
Faecalibacterium,
Akkermansia
Roseburia
were
negatively
associated
T2D,
while
Ruminococcus,
Fusobacterium,
Blautia
positively
T2D.
also
discussed
molecular
mechanisms
effects
onset
progression
Annals of the New York Academy of Sciences,
Journal Year:
2019,
Volume and Issue:
1461(1), P. 37 - 52
Published: May 14, 2019
Obesity
is
a
complex
metabolic
disease
caused,
in
part,
by
the
interaction
between
an
individual's
genetics,
metabolism,
and
environment.
Emerging
evidence
supports
role
of
gut
microbiota
mediating
host
environment
extracting
energy
from
food
otherwise
indigestible
producing
metabolites
cytokines
that
affect
metabolism.
Furthermore,
microbial
imbalance
or
dysbiosis
has
been
shown
diseases
including
obesity,
recent
studies
are
beginning
to
unravel
mechanisms
involved.
The
affects
metabolism
obesity
through
several
pathways
involving
barrier
integrity,
production
affecting
satiety
insulin
resistance,
epigenetic
factors,
bile
acids
subsequent
changes
signaling.
While
field
microbiome
its
early
stage
development,
it
holds
promising
future
providing
us
with
novel
therapeutic
targets
may
restore
healthy
state
help
prevention
treatment
obesity.
Reproduction,
Journal Year:
2019,
Volume and Issue:
158(3), P. R79 - R90
Published: April 18, 2019
In
the
United
States,
36.5%
of
women
between
ages
20
and
39
years
are
obese.
This
obesity
results
in
not
only
metabolic
disorders
including
type
II
diabetes
cardiovascular
disease,
but
also
impaired
female
fertility.
Systemic
tissue-specific
chronic
inflammation
oxidative
stress
common
characteristics
obesity.
is
true
ovary.
Several
studies
have
demonstrated
that
pro-inflammatory
cytokines
reactive
oxygen
species
alter
estrous
cyclicity,
steroidogenesis
ovulation.
Inflammation
impair
meiotic
cytoplasmic
maturation
oocyte
which
reduces
its
developmental
competence
for
fertilization
pre-implantation
embryo
development.
Interestingly,
there
recent
evidence
obesity-
and/or
polycystic
ovary
syndrome
(PCOS)-dependent
changes
to
gut
microbiome
contributes
ovarian
inflammation,
expression
mRNAs
oocyte.
However,
several
gaps
remain
necessitating
future
identify
mechanisms
reduce
function
quality.
New England Journal of Medicine,
Journal Year:
2020,
Volume and Issue:
383(8), P. 721 - 732
Published: Aug. 19, 2020
Some
studies
have
suggested
that
in
people
with
type
2
diabetes,
Roux-en-Y
gastric
bypass
has
therapeutic
effects
on
metabolic
function
are
independent
of
weight
loss.
Obesity Reviews,
Journal Year:
2017,
Volume and Issue:
18(8), P. 832 - 851
Published: May 19, 2017
Summary
Imbalances
in
the
gut
microbiota,
bacteria
that
inhabit
intestines,
are
central
to
pathogenesis
of
obesity.
This
systematic
review
assesses
association
between
microbiota
and
weight
loss
overweight/obese
adults
its
potential
manipulation
as
a
target
for
treating
identified
43
studies
using
keywords
‘overweight’
or
‘obesity’
‘microbiota’
related
terms;
among
these
studies,
17
used
dietary
interventions,
11
bariatric
surgery
15
manipulation.
The
differed
their
methodologies
well
intervention
lengths.
Restrictive
diets
decreased
abundance,
correlated
with
nutrient
deficiency
rather
than
generally
reduced
butyrate
producers
Firmicutes,
Lactobacillus
sp.
Bifidobacterium
impact
surgical
depended
on
given
technique
showed
similar
effect
producers,
addition
increasing
presence
Proteobacteria
phylum,
which
is
changes
intestinal
absorptive
surface,
pH
digestion
time.
Probiotics
strain
duration
diverse
effects
they
tended
reduce
body
fat.
Prebiotics
had
bifidogenic
increased
likely
due
cross‐feeding
interactions,
contributing
barrier
improving
metabolic
outcomes.
All
interventions
under
consideration
impacts
although
did
not
always
correlate
loss.
These
results
show
restrictive
microbial
abundance
promote
composition
could
have
long‐term
detrimental
colon.
In
contrast,
prebiotics
might
restore
healthy
microbiome
Journal of Endocrinological Investigation,
Journal Year:
2018,
Volume and Issue:
42(2), P. 117 - 128
Published: May 5, 2018
The
worldwide
obesity
epidemic
continues
unabated,
adversely
impacting
upon
global
health
and
economies.
People
with
severe
suffer
the
greatest
adverse
consequences
reduced
life
expectancy.
Currently,
bariatric
surgery
is
most
effective
treatment
for
people
obesity,
resulting
in
marked
sustained
weight
loss,
improved
obesity-associated
comorbidities
mortality.
Sleeve
gastrectomy
(SG)
Roux-en-Y
gastric
bypass
(RYGB),
common
procedures
undertaken
globally,
engender
loss
metabolic
improvements
by
mechanisms
other
than
restriction
malabsorption.
It
now
clear
that
a
plethora
of
gastrointestinal
(GI)
tract-derived
signals
plays
critical
role
energy
glucose
regulation.
SG
RYGB,
which
alter
GI
anatomy
nutrient
flow,
impact
these
ultimately
leading
to
improvements.
However,
whilst
highly
overall,
at
individual
level,
post-operative
outcomes
are
variable,
proportion
patients
experiencing
poor
long-term
outcome
gaining
little
benefit.
RYGB
markedly
different
anatomically
thus
differentially
signalling
bodyweight
Here,
we
review
proposed
cause
following
SG.
We
highlight
similarities
differences
between
two
focus
on
gut
hormones,
bile
acids
microbiota.
A
greater
understanding
procedure-related
will
allow
surgical
procedure
choice
be
tailored
maximise
post-surgery
facilitate
discovery
non-surgical
treatments
obesity.
Nutrients,
Journal Year:
2019,
Volume and Issue:
11(4), P. 766 - 766
Published: April 1, 2019
Type
2
diabetes
(T2D)
has
long
been
identified
as
an
incurable
chronic
disease
based
on
traditional
means
of
treatment.
Research
now
exists
that
suggests
reversal
is
possible
through
other
have
only
recently
embraced
in
the
guidelines.
This
narrative
review
examines
evidence
for
T2D
using
each
three
methods,
including
advantages
and
limitations
each.
Alimentary Pharmacology & Therapeutics,
Journal Year:
2020,
Volume and Issue:
51(6), P. 582 - 602
Published: Feb. 13, 2020
Abstract
Background
Helicobacter
pylori
is
the
most
infamous
constituent
of
gastric
microbiota
and
its
presence
strongest
risk
factor
for
cancer
other
gastroduodenal
diseases.
Although
historically
healthy
stomach
was
considered
a
sterile
organ,
we
now
know
it
colonised
with
complex
microbiota.
However,
role
in
health
disease
not
well
understood.
Aim
To
systematically
explore
literature
on
as
gut
after
bariatric
surgery.
Methods
A
systematic
search
online
bibliographic
databases
MEDLINE/EMBASE
performed
between
1966
February
2019
screening
accordance
Preferred
Reporting
Items
Systematic
Reviews
Meta‐Analyses
guidelines.
Randomised
controlled
trials,
cohort
studies
observational
were
included
if
they
reported
next‐generation
sequencing
derived
analysis
aspirate/tissue
or
stool
samples
(bariatric
surgical
outcomes).
Results
Sixty‐five
papers
eligible
inclusion.
With
exception
H
‐induced
conditions,
overarching
signatures
could
be
determined.
Gastric
carcinogenesis
induces
progressively
altered
an
enrichment
oral
intestinal
taxa
significant
changes
host
mucin
expression.
Proton
pump
inhibitors
usage
increases
richness.
Bariatric
surgery
associated
increase
potentially
pathogenic
proteobacterial
species
patient
samples.
Conclusion
While
remains
single
important
disease,
capacity
to
shape
collective
fully
elucidated.
Further
are
needed
intricate
host/microbial
microbial/microbial
interplay.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(1), P. 480 - 480
Published: Jan. 1, 2022
Diabetes
mellitus
is
a
significant
clinical
and
therapeutic
problem
because
it
can
lead
to
serious
long-term
complications.
Its
pathogenesis
not
fully
understood,
but
there
are
indications
that
dysbiosis
play
role
in
the
development
of
diabetes,
or
appears
during
course
disease.
Changes
microbiota
composition
observed
both
type
1
diabetes
(T1D)
2
(T2D)
patients.
These
modifications
associated
with
pro-inflammation,
increased
intestinal
permeability,
endotoxemia,
impaired
β-cell
function
insulin
resistance.
This
review
summarizes
gut
healthy
individuals
changes
bacterial
be
T1D
T2D.
It
also
presents
new
developments
therapy
based
on
influencing
as
promising
method
alter
diabetes.
Moreover,
highlights
lacking
data
suggests
future
directions
needed
prove
causal
relationship
between
