Covalent organic frameworks (COFs) as carrier for improved drug delivery and biosensing applications

Biotechnology and Bioengineering, Journal Year: 2024, Volume and Issue: 121(7), P. 2017 - 2049

Published: April 25, 2024

Porous organic frameworks (POFs) represent a significant subclass of nanoporous materials in the field science, offering exceptional characteristics for advanced applications. Covalent (COFs), as novel and intriguing type porous material, have garnered considerable attention due to their unique design capabilities, diverse nature, wide-ranging The structural features COFs, such high surface area, tuneable pore size, chemical stability, render them highly attractive various applications, including targeted controlled drug release, well improving sensitivity selectivity electrochemical biosensors. Therefore, it is crucial comprehend methods employed creating COFs with specific properties that can be effectively utilized biomedical To address this indispensable fact, review paper commences concise summary different classifications synthesizing COFs. Second, highlights recent advancements delivery, carriers classification delivery systems biosensing, encompassing drugs, biomacromolecules, small biomolecules detection biomarkers. While exploring potential field, important acknowledge limitations researchers may encounter, which could impact practicality Third, concludes thought-provoking discussion thoroughly addresses challenges opportunities associated leveraging This aims contribute scientific community's understanding immense enhancing performance biosensors

Language: Английский

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Large Area Film of Highly Crystalline, Cleavable, and Transferable Semi-Conducting 2D-Imine Covalent Organic Framework on Dielectric Glass Substrate

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(23), P. 30485 - 30495

Published: May 30, 2024

Two dimensional (2D) imine-based covalent organic framework (COF), 2D-COF, is a newly emerging molecular 2D polymer with potential applications in thin film electronics, sensing, and catalysis. It considered an ideal candidate due to its robust nature precise tunability of the electronic functional properties. Herein, we report scalable facile synthesis imine-COF control over thickness (ranging from 100 nm few monolayers) dimension reaching up 2 cm on dielectric (glass) substrate. Highly crystalline imine films are formed by maintaining quasi-equilibrium (very slow, ∼15 h) Schiff base condensation reaction between p-phenylenediamine (PDA) benzene-1,3,5-tricarboxaldehyde (TCA) molecules. Free-standing ultrathin obtained using sonication exfoliation 2D-COF polymer. Insights into microstructure thin/ultrathin scanning transmission electron microscopy (SEM TEM) atomic force (AFM), which shows high crystallinity layered structure both films. The chemical was established X-ray photoelectron spectroscopy (XPS). Optical band gap measurements also reveal semiconducting gap. This further calculation density theory (DFT), reveals semiconductor-like strong dispersion bands near conduction valence edges. structural characteristics (layered morphology microscopic structure) show significant for application device fabrication. In addition, frontier bands, making it material charge carrier transportation devices.

Language: Английский

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Synthesis and Analysis of Novel Polyamide COF-TH as a Potent Anticancer Delivery Vehicle Under Variable pH Conditions

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(5), P. 5217 - 5229

Published: Aug. 29, 2024

Language: Английский

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