Chemical Papers, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 18, 2024
Language: Английский
ACS Synthetic Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 21 - 40
Published: Jan. 6, 2025
The field of healthcare diagnostics is navigating complex challenges driven by evolving patient demographics and the rapid advancement new technologies worldwide. In response to these challenges, biosensors offer distinctive advantages over traditional diagnostic methods, such as cost-effectiveness, enhanced specificity, adaptability, making their integration with point-of-care (POC) platforms more feasible. recent years, aptasensors have significantly evolved in capabilities through emerging microfluidics, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems, wearable devices, machine learning (ML), driving progress precision medicine global solutions. Moreover, advancements not only improve accuracy but also hold potential revolutionize early detection, reduce costs, outcomes, especially resource-limited settings. This Account examines key advancements, focusing on how scientific breakthroughs, including artificial intelligence (AI), improved sensitivity precision. Additionally, has enabled real-time monitoring data analysis, fostering advances personalized healthcare. Furthermore, commercialization aptasensor could increase availability clinical settings support use widespread solutions for health challenges. Hence, this review discusses technological improvements, practical uses, prospects while surrounding standardization, validation, interdisciplinary collaboration application. Finally, ongoing efforts address are ensure that can be effectively implemented diverse systems.
Language: Английский
Citations
2
Biosensors, Journal Year: 2025, Volume and Issue: 15(2), P. 100 - 100
Published: Feb. 10, 2025
Understanding brain function requires advanced neural probes to monitor electrical and chemical signaling across multiple timescales regions. Microelectrode arrays (MEAs) are widely used record neurophysiological activity various depths regions, providing single-unit resolution for extended periods. Recent advancements in flexible MEAs, built on micrometer-thick polymer substrates, have improved integration with tissue by mimicking the brain's soft nature, reducing mechanical trauma inflammation. These flexible, subcellular-scale MEAs can stable signals months, making them ideal long-term studies. In addition recording, been functionalized electrochemical neurotransmitter detection. Electroactive neurotransmitters, such as dopamine, serotonin, adenosine, be directly measured via methods, particularly carbon-based surfaces. For non-electroactive neurotransmitters like acetylcholine, glutamate, γ-aminobutyric acid, alternative strategies, enzyme immobilization aptamer-based recognition, employed generate signals. This review highlights recent developments MEA fabrication functionalization achieve both electrophysiological recordings, minimizing sensor fowling damage when implanted long-term. It covers multi-time scale detection, development of conducting nanomaterial composite coatings enhance sensitivity, incorporation recognition carbon electrodes MEAs. Finally, it summarizes strategies acquire measurements from same device.
Language: Английский
Citations
1
Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 567, P. 120091 - 120091
Published: Dec. 15, 2024
Language: Английский
Citations
3
Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 189, P. 109984 - 109984
Published: March 14, 2025
Language: Английский
Citations
0
Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(6)
Published: May 28, 2025
Language: Английский
Citations
0
Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 566, P. 120039 - 120039
Published: Nov. 15, 2024
Language: Английский
Citations
1
Chemical Papers, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 18, 2024
Language: Английский
Citations
1