Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract The modulation of gut microbiota presents promising therapeutic possibilities for various health conditions, ranging from gastrointestinal infections to neurodegenerative and mental disorders. Among the available interventions, modulators (GMMs) such as probiotics prebiotics have demonstrated significant potential in infection prevention neuroprotection. Despite these encouraging findings, clinical application GMMs remains challenging due safety concerns inconsistent effectiveness across diverse patient populations. These factors create substantial barriers widespread adoption microbiota-based therapies practice. To overcome challenges fully leverage modulation, this review explores feasibility repurposing managing multiple A broad spectrum microbiota-targeted strategies is examined, including dietary modifications, fecal transplantation, bacteriophage therapy, microbiome engineering, immune system modulation. particularly innovative approach involves integrating with pharmaceutical delivery systems enhance efficacy while mitigating adverse effects. This integrative strategy underscores pivotal role disease, supporting development precision medicine tailored individual needs. By combining targeted mechanisms, not only improves treatment but also addresses critical regarding variability. Furthermore, outlines future research directions within rapidly evolving field emphasizing necessity comprehensive trials long-term evaluations. critically assessing both opportunities associated study provides a strategic framework translating experimental into viable applications. holistic has redefine paradigms, offering personalized wide range disorders advancing broader medicine.

Language: Английский