Handbook of Religion and Health

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

Abstract The 2001 (first) edition of this Handbook was a comprehensive review history, research, and discussions on religion health through the year 2000. Appendix listed 1,200 separate quantitative studies each rated in quality 0–10 scale, followed by about 2,000 references an extensive index for rapid topic identification. 2012 (second) systematically updated research from 2000 to 2010, with number then reaching thousands. This 2023 (third) is most scientifically rigorous date, covering best published 2021 emphasis prospective randomized controlled trials. Beginning Foreword Dr. Howard K. Koh, former US Assistant Secretary Health Department Human Services, nearly 600,000-word volume examines almost every aspect health, reviewing past more recent relationship between outcomes. Furthermore, all its 34 chapters conclude clinical community applications, making text relevant both healthcare professionals (physicians, nurses, social workers, rehabilitation therapists, counselors, psychologists, sociologists, etc.) clergy (community clergy, chaplains, pastoral etc.). book’s focuses studies, describing study single line, allowing researchers quickly locate existing research. It should not be surprising that two decades has been cited health.

Language: Английский

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Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors

Diabetes/Metabolism Research and Reviews, Journal Year: 2021, Volume and Issue: 38(3)

Published: Oct. 8, 2021

Metabolic syndrome (MS) is a chronic non-infective characterised clinically by set of vascular risk factors that include insulin resistance, hypertension, abdominal obesity, impaired glucose metabolism, and dyslipidaemia. These are due to pro-inflammatory state, oxidative stress, haemodynamic dysfunction, ischaemia, which overlap in 'dysmetabolic' patients. This review aimed evaluate the relationship between traditional components MS with cardiovascular disease (CVD), inflammation, stress. MEDLINE-PubMed, EMBASE, Cochrane databases were searched. Chronic low-grade inflammatory states metaflammation often accompanied metabolic changes directly related CVD incidence, such as diabetes mellitus, obesity. Moreover, an increase serum concentration cytokines, mainly interleukin-1 β (IL-1β), IL-6, tumour necrosis factor-α (TNF-α), originating from chronically inflamed adipose tissue associated The reactive oxygen species overloads antioxidant systems causing post-translational alterations proteins, lipids, DNA leading Hyperglycaemia contributes stress production advanced glycosylation end products (AGEs) cellular molecular dysfunction. Oxidative inflammation senescence CVD. should not be seen only being triggered classical factors. Atherosclerosis multifactorial pathological process several triggering aetiopathogenic mechanisms. Its medium long-term repercussions, however, invariably constitute significant cause morbidity mortality. Implementing preventive therapeutic measures against oxy-reductive imbalances has unquestionable potential for favourable clinical outcomes medicine.

Language: Английский

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Stress and inflammation – The need to address the gap in the transition between acute and chronic stress effects

Psychoneuroendocrinology, Journal Year: 2019, Volume and Issue: 105, P. 164 - 171

Published: Feb. 21, 2019

Language: Английский

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The Role of Inflammation in Cardiovascular Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 12906 - 12906

Published: Oct. 26, 2022

Atherosclerosis is a chronic inflammatory disease, in which the immune system has prominent role its development and progression. Inflammation-induced endothelial dysfunction results an increased permeability to lipoproteins their subendothelial accumulation, leukocyte recruitment, platelets activation. Recruited monocytes differentiate into macrophages develop pro- or anti-inflammatory properties according microenvironment. Atheroma progression healing determined by balance between these functional phenotypes. Macrophages smooth muscle cells secrete cytokines including interleukins IL-1β, IL-12, IL-6. Within arterial wall, low-density lipoprotein cholesterol undergoes oxidation. Additionally, triglyceride-rich remnant exert pro-inflammatory effects. catabolize oxidized coalesce lipid-rich necrotic core, encapsulated collagen fibrous cap, leading formation of fibro-atheroma. In conditions inflammation, catabolic effect on resulting thin-cap fibro-atheroma makes plaque vulnerable. However, morphology may change over time, shifting from high-risk lesions more stable calcified plaques. addition conventional cardiovascular risk factors, exposure acute psychological stress increase disease through inflammation mediated sympathetic output release cytokines. Inflammation also link ageing clones leukocytes peripheral blood. Anti-inflammatory interventions specifically blocking cytokine pathways reduce myocardial infarction stroke, although they infections.

Language: Английский

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Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(23), P. 11370 - 11379

Published: May 21, 2019

Aging and psychosocial stress are associated with increased inflammation disease risk, but the underlying molecular mechanisms unclear. Because both aging also lasting epigenetic changes, a plausible hypothesis is that along lifespan could confer risk through effects on molecules involved in inflammatory processes. Here, by combining large-scale analyses human cohorts experiments cells, we report FKBP5, protein implicated physiology, contributes to these relations. Across independent (total n > 3,000), synergized stress-related phenotypes, measured childhood trauma major depression questionnaires, epigenetically up-regulate FKBP5 expression. These age/stress-related were recapitulated cellular model of replicative senescence, whereby exposed replicating fibroblasts (glucocorticoid) hormones. Unbiased genome-wide blood linked higher mRNA proinflammatory profile altered NF-κB–related gene networks. Accordingly, immune cells showed promotes strengthening interactions NF-κB regulatory kinases, whereas opposing either genetic deletion (CRISPR/Cas9-mediated) or selective pharmacological inhibition prevented NF-κB. Further, signature enhanced response positive feedback loop was present individuals history acute myocardial infarction, state peripheral inflammation. findings suggest aging/stress-driven FKBP5–NF-κB signaling mediates inflammation, potentially contributing cardiovascular may thus point novel biomarker treatment possibilities.

Language: Английский

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Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review

Molecules, Journal Year: 2023, Volume and Issue: 28(17), P. 6403 - 6403

Published: Sept. 1, 2023

Fruits, vegetables, and other food items contain phytochemicals or secondary metabolites which may be considered non-essential nutrients but have medicinal importance. These dietary exhibit chemopreventive therapeutic effects against numerous diseases. Polyphenols are found in fruits, grains. compounds several health benefits such as immune modulators, vasodilators, antioxidants. This review focuses on recent studies using polyphenols to treat cardiovascular disorders, atherosclerosis, vascular endothelium deficits. We focus exploring the safety of highly effective ensure their maximum impact cardiac abnormalities discuss epidemiological evidence intervention trials related these properties. Kaempferol, quercetin, resveratrol prevent oxidative stress by regulating proteins that induce oxidation heart tissues. In addition, modulate tone vessels releasing nitric oxide (NO) reducing low-density lipoprotein (LDL) atherosclerosis. cardiomyocytes, suppress expression inflammatory markers inhibit production inflammation exert an anti-inflammatory response. Consequently, diseases strokes, hypertension, failure, ischemic disease could prevented polyphenols.

Language: Английский

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Unravelling the complexities of depression with medical intelligence: exploring the interplay of genetics, hormones, and brain function

Complex & Intelligent Systems, Journal Year: 2024, Volume and Issue: 10(4), P. 5883 - 5915

Published: April 4, 2024

Abstract Depression is a multifactorial disease with unknown etiology affecting globally. It’s the second most significant reason for infirmity in 2020, about 50 million people worldwide, 80% living developing nations. Recently, surge depression research has been witnessed, resulting multitude of emerging techniques developed prediction, evaluation, detection, classification, localization, and treatment. The main purpose this study to determine volume conducted on different aspects such as genetics, proteins, hormones, oxidative stress, inflammation, mitochondrial dysfunction, associations other mental disorders like anxiety stress using traditional medical intelligence (medical AI). In addition, it also designs comprehensive survey treatment planning, genetic predisposition, along future recommendations. This work designed through methods, including systematic mapping process, literature review, network visualization. we used VOSviewer software some authentic databases Google Scholar, Scopus, PubMed, Web Science data collection, analysis, designing picture study. We analyzed 60 articles related intelligence, 47 from machine learning 513,767 subjects (mean ± SD = 10,931.212 35,624.372) 13 deep 37,917 3159.75 6285.57). Additionally, found that stressors impact brain's cognitive autonomic functioning, increased production catecholamine, decreased cholinergic glucocorticoid activity, cortisol. These factors lead chronic inflammation hinder normal leading depression, anxiety, cardiovascular disorders. brain, reactive oxygen species (ROS) by IL-6 stimulation cytochrome c oxidase inhibited nitric oxide, potent inhibitor. Proteins, lipids, phosphorylation enzymes, mtDNA are further disposed impairment mitochondria. Consequently, dysfunction exacerbates impairs DNA (mtDNA) or deletions mtDNA, increases intracellular Ca 2+ levels, changes fission/fusion morphology, lastly leads neuronal death. highlights multidisciplinary approaches intelligence. It will open new way technologies.

Language: Английский

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Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence

Nature Reviews Cardiology, Journal Year: 2018, Volume and Issue: 15(9), P. 523 - 542

Published: July 27, 2018

Language: Английский

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Significance of psychosocial factors in cardiology: update 2018

Clinical Research in Cardiology, Journal Year: 2019, Volume and Issue: 108(11), P. 1175 - 1196

Published: May 10, 2019

Language: Английский

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Retinal and choroidal vascular changes in coronary heart disease: an optical coherence tomography angiography study

Biomedical Optics Express, Journal Year: 2019, Volume and Issue: 10(4), P. 1532 - 1532

Published: March 4, 2019

To reveal the association between retinal microvasculature changes and coronary heart disease (CHD), we assessed full thicknesses of eight areas, vessel density four layers (consisting nine areas) flow area in two with optical coherence tomography angiography (OCTA) CHD patients healthy controls. The mean several was significantly lower patients. difference choroid capillary (negative correlation) groups significant. Decreased blood were associated artery branch stenosis. decreases density, choroidal are closely related to

Language: Английский

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