Elevated triglyceride-glucose index is a risk factor for cardiovascular events in adults with type 1 diabetes: a cohort study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 2, 2025

Language: Английский

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Causal association between type 1 diabetes and autoimmune cholestasis: A bi-directional Mendelian randomized study

International Journal of Immunopathology and Pharmacology, Journal Year: 2025, Volume and Issue: 39

Published: March 1, 2025

Explore the causal relationship of risk between type 1 diabetes and primary biliary cholangitis (PBC) sclerosing (PSC). A association autoimmune liver disease remains ambiguous. This study explored potential causality different conditions, indicating that caution should be taken occurrence diseases in daily management T1D patients. Genetic variants were extracted as instrumental variables from genome-wide (GWAS) PBC, PSC, (T1D), 2 (T2D). Associations four enzymes, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine transferase (ALT), glutamyl transaminase (GGT), blood glucose-related indicators such 2h-glucose post-challenge (2hGlu), fasting glucose (FG), insulin (FI), glycated hemoglobin (HbA1c) also evaluated (GWAS p-value < 5 × 10 −8 ). bi-directional two-sample Mendelian randomization (MR) design was used to assess cholestasis. susceptibility increased PSC PBC. T2D reduced showed no correlation with Genetically PBC T2D. did not impact patients have an PBC/PSC, but causation is mediated or explained by altered levels. identified The findings provide new insight into these conditions.

Language: Английский

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Recurrent hypoglycaemia leads to impairment in glucagon‐mediated hepatic glycogenolysis in type 1 diabetic mice

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 20, 2025

Abstract Aims To explore the alterations in pancreatic α cells and hepatic glycogen metabolism mice with type 1 diabetes mellitus (T1DM) following recurrent hypoglycaemia, aiming to elucidate underlying mechanisms that contribute impaired counterregulatory responses hypoglycaemia. Materials/Methods The glycogenolysis were assessed T1DM experiencing hypoglycaemia induced by insulin. Furthermore, glucagon intervention experiments conducted on subjected their primary hepatocytes clarify further responsible for observed changes glycogenolysis. Results In mice, led a reduction of cell mass decrease synthesis secretion these cells, indicating compromised response repeated hypoglycaemic episodes disrupted glycogenolysis, thereby diminishing liver's ability respond expression receptors was closely associated impairment ultimately leading reduced hyperglycaemic effect exogenous glucagon. Conclusions Pancreatic play significant role developing hypoglycaemia; however, is even more critical. Recurrent can lead liver, resulting counterregulation.

Language: Английский

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ANÁLISE DOS IMPACTOS DO DIABETES MELLITUS TIPO 1 NO DESENVOLVIMENTO PSICOSSOCIAL EM CRIANÇAS DE ZERO A DEZ ANOS NO CONTINENTE AMERICANO: REVISÃO NARRATIVA DA LITERATURA

Revista Contemporânea, Journal Year: 2025, Volume and Issue: 5(4), P. e7958 - e7958

Published: April 23, 2025

A diabetes Mellitus tipo 1 é caracterizada por uma doença crônica que acomete qualquer indivíduo, especialmente a faixa etária pediátrica, podendo em decorrência à cursar com malefícios no desenvolvimento psicossocial dessas crianças. Para isso, o presente estudo foi realizado intuito de avaliar os impactos causados pela sob crianças entre zero dez anos continente americano. Trata-se revisão narrativa da literatura, onde foram através das bases dados: LILACS, SCIELO e PubMed selecionados trabalhos constassem tema supracitado estivessem 2020 2024. Dessa forma, desses, vistos notórios desafios ligados DM1 ao infantil, trazendo tona, portanto necessidade adaptações para lidar tal crônica, além necessitar abordagens multidisciplinares provocados sejam amenizados garantida melhor qualidade vida.

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Characterization of Perinatal Stem Cell Spheroids for the Development of Cell Therapy Strategy

Bioengineering, Journal Year: 2023, Volume and Issue: 10(2), P. 189 - 189

Published: Feb. 2, 2023

Type 1 diabetes mellitus (T1DM) is a complex metabolic disease characterized by massive loss of insulin-producing cells due to an autoimmune reaction. Currently, daily subcutaneous administration exogenous insulin the only effective treatment. Therefore, in recent years considerable interest has been given stem cell therapy and particular use three-dimensional (3D) cultures better reproduce vivo conditions. The goal this study provide reliable cellular model that could be investigated for regenerative medicine applications replacement T1DM. To pursue aim we create co-culture spheroid amniotic epithelial (AECs) Wharton's jelly mesenchymal stromal (WJ-MSCs) one-to-one ratio. resulting spheroids were analyzed viability, extracellular matrix production, hypoxic state both early- long-term cultures. Our results suggest are stable culture still viable with consistent production evaluated immunofluorescence staining. These findings may potentially differentiated into endo-pancreatic

Language: Английский

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Association of autoimmune thyroid disease with type 1 diabetes mellitus and its ultrasonic diagnosis and management

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(3), P. 348 - 360

Published: March 15, 2024

As a common hyperglycemic disease, type 1 diabetes mellitus (T1DM) is complicated disorder that requires lifelong insulin supply due to the immune-mediated destruction of pancreatic β cells. Although it an organ-specific autoimmune disorder, T1DM often associated with multiple other disorders. The most prevalent concomitant occurring in thyroid disease (AITD), which mainly exhibits two extremes phenotypes: hyperthyroidism [Graves' (GD)] and hypo-thyroidism [Hashimoto's thyroiditis, (HT)]. However, presence comorbid AITD may negatively affect metabolic management patients thereby increase risk for potential diabetes-related complications. Thus, routine screening function has been recommended when diagnosed. Here, first, we summarize current knowledge regarding etiology pathogenesis mechanisms both diseases. Subsequently, updated review association between offered. Finally, provide relatively detailed focusing on application ultrasonography diagnosing managing HT GD, suggesting its critical role timely accurate diagnosis T1DM.

Language: Английский

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Challenging directions in pediatric diabetes - the place of oxidative stress and antioxidants in systemic decline

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 18, 2024

Diabetes is a complex condition with rising global incidence, and its impact equally evident in pediatric practice. Regardless of whether we are dealing type 1 or 2 diabetes, the development complications following onset disease inevitable. Consequently, contemporary medicine must concentrate on understanding pathophysiological mechanisms driving systemic decline finding ways to address them. We particularly interested effects oxidative stress target cells organs, such as pancreatic islets, retina, kidneys, neurological cardiovascular systems. Our goal explore, using latest data from international scientific databases, relationship between persistence damage associated diabetes children. Additionally, highlight beneficial roles antioxidants vitamins, minerals, polyphenols, other bioactive molecules; mitigating pathogenic cascade, detailing how they intervene their properties. As result, our study provides comprehensive exploration key aspects stress-antioxidants-pediatric triad, expanding significance various diseases.

Language: Английский

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Investigating the Incidence of Dyslipidemia among Brazilian Children and Adolescents Diagnosed with Type 1 Diabetes Mellitus: A Cross-Sectional Study

Diseases, Journal Year: 2024, Volume and Issue: 12(3), P. 45 - 45

Published: Feb. 24, 2024

The treatment of Type 1 Diabetes Mellitus (T1DM) has always been a challenge for health professionals in relation to glycemic control. Increased body fat related worsening the lipid profile and increased prevalence dyslipidemia this population, leading negative repercussions on control cardiovascular risk. We aimed investigate distribution levels presence children adolescents with T1DM. A cross-sectional observational study was conducted 81 individuals both sexes (4–19 years) diagnosed Anthropometric biochemical data were collected, addition physical activity level, sexual maturation stage, insulin administration regimen. Lipid categorized as normal, borderline, elevated, by one or more altered parameter. noted 65.4% participants when considering borderline values. Of those, 23.5% had 42.0% two more. main total cholesterol triglycerides, followed non-HDL-c. factor associated increase HbA1c. Sex significant effect TC, HDL-c, ApoA-I. results reinforce need monitor T1DM, well importance early intervention treating dyslipidemia, especially patients poor

Language: Английский

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Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 601 - 601

Published: Jan. 24, 2023

The hypoglycemic and lipid-lowering effects of glucomannan are widely known, it is a potential effective treatment for type II diabetes. In this study, we evaluated the supplementation on blood-lipid-related indicators, blood-glucose-related blood pressure (BP), body weight (BW) in patients suffering from We searched databases including PubMed, Cochrane, comprehensive biomedical research database (Embase), Web Science, China National Knowledge Infrastructure (CNKI) literature Six randomized controlled trials (RCTs) were eligible (n = 440 participants) to be included our analysis. Glucomannan not only reduced total cholesterol (TC) (MD −0.38 [95% CI: −0.61, −0.15], p 0.001) low-density lipoprotein (LDL) levels −0.35 −0.52, −0.17], < 0.0001) compared with control group, but also fasting glucose (FBG) −1.08 −1.65, −0.50], 0.0002), 2 h postprandial (P2hBG) −1.92 −3.19, −0.65], 0.003), insulin (FINS) −1.59 −2.69, 0.004), serum fructosamine (SFRA) (SMD −1.19 −1.74, −0.64], 0.0001). Our analysis indicates that an nutritional intervention

Language: Английский

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Hypoglycemia in Type 1 Diabetes Mellitus

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: March 21, 2024

Hypoglycemia is a common problem in patients with type 1 diabetes and can be asymptomatic, mild, severe. Despite therapeutic approaches technological advances, hypoglycemia continues to an important cause of morbidity mortality patients. Impairment counterregulatory defense mechanisms unawareness are the main risk factors for hypoglycemia. Recurrent episodes awareness defective counter-regulation, resulting hypoglycemia-associated autonomic deficiency (HAAF) syndrome. Efforts needed prevent hypoglycemia, include glucose monitoring, patient education, medication adjustment. Advances technology, such as insulin pumps devices that allow continuous significantly reduce when used appropriately.

Language: Английский

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