Better Cardiorespiratory Fitness Defined as VO₂max Increases the Chance of Partial Clinical Remission and Prolongs Remission Duration in People with Newly Diagnosed Type 1 Diabetes

Clinical Medicine Insights Endocrinology and Diabetes, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 1, 2024

Introduction: An essential process affecting the course of type 1 diabetes (DM1) is appearance and duration clinical remission. One most important factors promoting occurrence remission physical activity, due to increased activity antioxidants, reduces insulin resistance improves glucose transport. Maximal oxygen capacity (VO 2 max) an objective measure body’s aerobic capacity. To assess VO max, uptake should be measured directly during exercise test. The aim study was evaluate in adults with DM1 its relationship partial (pCR) years follow-up. Methods: pCR assessed by following mathematical formula: A1c (%) + [4 × dose (U/kg/d)]. result ⩽9 indicates pCR. max between 6th 24th month using ergospirometer (COSMED K5 System), test carried out on a cycloergometer (RAMP incremental test). Results: group consisted 32 DM1. People were proved have higher level [36.0 (33.0-41.5) vs 30.9 (26.5-34.4) ml/min/kg, P = .009. Univariate multivariate regression confirmed significant association presence [AOR 1.26 (1.05-1.52), .015]. Duration longer among results [15 (9-24) 9 (0-12) months, .043]. positive observed (rs 0.484, .005). Multivariate linear confirms (ml/min/kg) (β 0.595, .002). Conclusion: better chance at

Language: Английский

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Genetic causality between type 1 diabetes and arrhythmia identified by a two-sample Mendelian randomization study

Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 213, P. 111725 - 111725

Published: May 31, 2024

Language: Английский

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Evaluating the Diagnostic Accuracy of Anti- Zinc Transporter 8 Antibodies in Type 1 Diabetes: A Systematic Review and Meta-Analysis

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 9, 2024

ABSTRACT Background The association between autoantibodies and the risk of type 1 diabetes mellitus (T1DM) is well established. However, there still a lack quantitative insight into role anti-zinc transporter 8 (anti-ZnT8) antibodies their efficacy in T1DM diagnosis. Objective To conduct systematic review meta-analysis on anti-ZnT8 T1DM. Methods Relevant studies were retrieved from PubMed database analyzed using fixed or random-effects model. Results Out 211 screened articles, 23 selected total 14,172 patients included analysis. Our pooled analysis revealed that autoantibody expression was significantly associated with an increased development both children adults [OR 1.14 (95% CI: 1.12-1.16); P = 0.07]. Conclusion provides robust evidence supporting significant positivity development.

Language: Английский

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Incidence of Type 1 Diabetes in Children Aged 0–14 Years in Trentino–Alto Adige Region and Determinants of Onset with Ketoacidosis

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(10), P. 1055 - 1055

Published: Oct. 11, 2024

To assess the incidence and temporal trend of type 1 diabetes (T1D) diabetic ketoacidosis (DKA) during period 2014-2023 in youths aged 0-14 years Trentino-Alto Adige region, Italy.

Language: Английский

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Distinguishing risk factors for depression and burnout in parents managing type 1 diabetes mellitus in children

Journal of Pediatric Nursing, Journal Year: 2024, Volume and Issue: 80, P. 32 - 40

Published: Nov. 14, 2024

Language: Английский

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