Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis

Diagnostics, Journal Year: 2023, Volume and Issue: 13(3), P. 491 - 491

Published: Jan. 29, 2023

(1) Background: Long COVID syndrome is a significant cause of morbidity in COVID-19 patients who remain symptomatic with varied clinical presentations beyond three weeks. Furthermore, the relevance considering cardiovascular outcomes post-COVID-19 important current pandemic; (2) Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed this systematic review meta-analysis. searches conducted from multiple databases without language restrictions until October 8, 2022, to find studies evaluating such as arrhythmias, myocardium pericardium diseases, coronary vessel disease, thromboembolic disorders post-COVID cases. pooled odds ratio (OR), standard mean difference (SMD) their corresponding 95% confidence intervals (CI) computed association; (3) Results: Altogether, seven total 8,126,462 (cases: 1,321,305; controls: 6,805,157) participants included Pooled ratios significantly higher cases (OR > 1, p < 0.05) than controls. However, mortality (OR: 4.76, = 0.13), heart rate variability (SMD: −0.06, 0.91) between controls not statistically significant; (4) Conclusions: Significant sequelae long highlight importance careful cardiac monitoring phase address complications soon possible; larger-scale prospective are required accurate estimation.

Language: Английский

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Quality of Life in COVID-Related ARDS Patients One Year after Intensive Care Discharge (Odissea Study): A Multicenter Observational Study

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(3), P. 1058 - 1058

Published: Jan. 29, 2023

Investigating the health-related quality of life (HRQoL) after intensive care unit (ICU) discharge is necessary to identify possible modifiable risk factors. The primary aim this study was investigate HRQoL in COVID-19 critically ill patients one year ICU discharge.

Language: Английский

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Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 835 - 835

Published: July 11, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Language: Английский

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Long-term cognitive and autonomic effects of COVID-19 in young adults: a cross-sectional study at 28 months

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Jan. 16, 2025

The COVID-19 pandemic, caused by SARS-CoV-2, has had profound global impacts since its emergence in late 2019. Whilst acute symptoms are well-documented, increasing evidence suggests long-term consequences extending beyond the phase. This study aimed to investigate cognitive and autonomic effects of young adults. We conducted a cross-sectional comparing adults with history (n = 34) matched controls 34). Cognitive function was assessed using Sternberg Task, Stroop Go/No-Go Task (GNG). Autonomic evaluated heart rate variability (HRV) parameters. average time interval between infection testing 28.2 months. group showed significantly increased reaction 2-item absent condition (p 0.044) errors 4-item present 0.012) neutral response 0.028) normalized for completing task 0.022) Task. No significant differences were found GNG HRV parameters did not differ groups, although trends toward higher overall observed group. Young who approximately 28 months ago show minimal impact on regulation. However, subtle inefficiencies persist, particularly working memory executive tasks. These findings suggest generally favorable prognosis following mild moderate but highlight need further investigation into persistent effects.

Language: Английский

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Echocardiographic Left Ventricular Function in the Third Year After COVID-19 Hospitalization: A Follow-Up Pilot Study in South-East of Romania

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 333 - 333

Published: Feb. 14, 2025

Background and Objectives: Cardiac involvement in COVID-19 has been confirmed during the acute stage of infection. However, prevalence spectrum post-infectious cardiac dysfunction remain incompletely clarified. The objective our study was to evaluate frequency echocardiographic changes 2 years after hospitalization for moderate severe patients with no previously known pathology. Material Methods: We conducted a retrospective cohort analyzing severity markers infection parameters assessed ≥2 illness, based on recent guideline recommended algorithm diagnostic left ventricular (LV) dysfunction. Results: included 50 Caucasian patients, 60% male, 54% aged < 65 years, 32% forms disease. primary comorbidities were hypertension, obesity, diabetes. correlated computed tomography (CT) lung lesion score neutrophil-to-lymphocyte ratio >6 but not associated post-COVID-19 changes. Left ejection fraction (LVEF) reduced only 18% cases, global longitudinal strain (GLS) impairment observed 46% contributing LV systolic subclinical 61%. Impaired diastolic disfunction normal pressure filling present 30.61% cases elevated 10.2%. Conclusions: is an independent predictive factor GLS impairment, which can indicate myocardial contractile dysfunction, even asymptomatic heart This underscores importance regular monitoring recovering from COVID-19.

Language: Английский

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Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes

Metabolites, Journal Year: 2023, Volume and Issue: 13(10), P. 1032 - 1032

Published: Sept. 25, 2023

Long COVID-19 patients show systemic inflammation and persistent symptoms such as fatigue malaise, profoundly affecting their quality of life. Since improving oxygenation can oppose at multiple tissue levels, we hypothesized that hyperbaric oxygen therapy (HBOT) could arrest progression thus relieve COVID-19. We evaluated oxy-inflammation biomarkers in long subjects treated with HBOT monitored non-invasive methods. Five (two athletes three other comorbidities) were assigned to receive HBOT: 100% inspired O2 2.4 ATA a multiplace chamber for 90 min (three athletes: 15 × 5 days/wk 3 weeks; two affected by Idiopathic Sudden Sensorineural Hearing Loss: 30 6 one patient osteomyelitis: week weeks and, after 30-day break, followed second cycle 20 HBOT). Using saliva and/or urine samples, reactive species (ROS), antioxidant capacity, cytokines, lipids peroxidation, DNA damage, renal status assessed T1_pre (basal level) T2_pre level treatment), the results showed attenuated ROS production, lipid NO metabolites, biomarker especially post-treatment. Thus, may represent an alternative method treating COVID-19-induced long-lasting manifestations oxy-inflammation.

Language: Английский

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Cardiovascular Manifestations of the Long COVID Syndrome

Cardiology in Review, Journal Year: 2023, Volume and Issue: Publish Ahead of Print

Published: April 10, 2023

While most coronavirus 2019 (COVID-19) survivors have had complete resolution of symptoms, a significant proportion suffered from incomplete recovery. Cardiopulmonary such as dyspnea, chest pain, and palpitations are responsible for substantial symptom burden in COVID-19 survivors. Studies revealed persistent myocardial injury with late gadolinium enhancement scar on cardiac magnetic resonance patients. Evidence edema, active inflammation, left ventricular dysfunction, right is limited to minority Large observational studies indicated an increased risk cardiovascular disease compared the general population, including coronary artery disease, cardiomyopathy, arrhythmias. Management long COVID focused supportive therapy reduce systemic inflammation. Patients high risk, namely, those who complications during acute illness, patients new onset cardiopulmonary symptoms postinfectious period, competitive athletes, should be evaluated by specialist. sequelae currently based expert guideline recommendations given lack evidence specific syndrome. In this review, we outline manifestations COVID, current supporting abnormalities recommended management these

Language: Английский

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From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8290 - 8290

Published: May 5, 2023

Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection triggers various events from molecular to tissue level, which in turn is given by the intrinsic characteristics of each patient. Given diversity characteristic cellular phenotype, possible cytopathic, and clinical effects are difficult predict, determines heterogeneity COVID-19 symptoms. The purpose this article provide a comprehensive review cytopathic SARS-CoV-2 on cell types, focusing development COVID-19, may lead, some patients, persistence symptoms after recovery disease, condition known as long COVID. We describe mechanisms underlying virus-host interactions, including alterations protein expression, intracellular signaling pathways, immune responses. In particular, highlights potential impact these cytopathies function outcomes, such dysregulation, neuropsychiatric disorders, organ damage. concludes discussing future directions for research implications management treatment

Language: Английский

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Elevated FAI Index of Pericoronary Inflammation on Coronary CT Identifies Increased Risk of Coronary Plaque Vulnerability after COVID-19 Infection

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7398 - 7398

Published: April 17, 2023

Inflammation is a key factor in the development of atherosclerosis, disease characterized by buildup plaque arteries. COVID-19 infection known to cause systemic inflammation, but its impact on local vulnerability unclear. Our study aimed investigate coronary artery (CAD) patients who underwent computed tomography angiography (CCTA) for chest pain early stages after infection, using an AI-powered solution called CaRi-Heart®. The included 158 (mean age was 61.63 ± 10.14 years) with angina and low intermediate clinical likelihood CAD, 75 having previous 83 without infection. results showed that had higher levels pericoronary inflammation than those did not have suggesting may increase risk destabilization. This highlights potential long-term cardiovascular health, importance monitoring managing factors recovering from CaRi-Heart® technology offer non-invasive way detect instability COVID-19.

Language: Английский

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A Three-Year Cross-Sectional Analysis of Depression, Anxiety, and Quality of Life in Patients with Post-COVID-19 Syndrome

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 751 - 762

Published: March 1, 2024

Background: This study explores the longitudinal psychosocial impact of Long-COVID syndrome, also known as Post-COVID-19 characterized by enduring symptoms after coronavirus disease (COVID-19) infection, over years 2020, 2021, and 2022. It aimed to examine variations in depression, anxiety, quality life among patients during these years, hypothesizing significant inter-year differences reflecting pandemic's evolving influence. Methods: Conducted at Victor Babes Hospital for Infectious Diseases Pulmonology, Romania, this cross-sectional research involved 324 diagnosed with mild moderate COVID-19, assessed six months post-hospitalization. Standardized instruments, namely Short Form (SF-36) life, Generalised Anxiety Disorder Assessment (GAD-7) Patient Health Questionnaire (PHQ-9) were utilized. Results: The observed a consistent average patient age around 55 across years. A notable increase COVID-19 vaccination rates was recorded, rising from 20.9% 2020 70% 2022 (p< 0.001). Trends key post-COVID like fatigue cognitive issues varied Importantly, there decrease feelings sadness or scores declining 7.3 4.8 SF-36 survey indicated steady improvement overall health, reaching 55.8± 7.1 (p=0.035). Both GAD-7 PHQ-9 showed reductions anxiety depression p-values 0.030 0.031, respectively. Factors such smoking status, substance use, initial severity infection significantly associated levels. Conclusion: findings suggest that despite persistent physical symptoms, experienced enhancements mental well-being studied period. increasing might have contributed improvement. Addressing modifiable risk factors use could further optimize care health outcomes. Keywords: SARS-CoV-2, long-COVID, post, acute COVID

Language: Английский

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