Characterisation of Post-Sepsis Cardiomyopathy Using Cardiovascular Magnetic Resonance DOI Creative Commons
Samuel Malomo, T Oswald, Edward R. Stephenson

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(8), P. 997 - 997

Published: April 14, 2025

Background: Post-sepsis cardiomyopathy is associated with an increased risk of adverse cardiovascular outcomes. It remains poorly understood, which limits therapeutic development. This study characterised post-sepsis using magnetic resonance (CMR) imaging. Methods: Patients admitted acute sepsis and suspected cardiac injury or heart failure who subsequently (47 days [IQR: 22-122]) underwent CMR at a UK tertiary centre were included. Age- gender-matched controls (n = 16) also Subjects 1.5 Tesla cines, native T1- T2-mapping, late gadolinium enhancement (LGE) Results: Of the 22 patients (age 50 ± 13 years; 64% males), (59%) had left ventricular (LV) dilatation. significantly elevated end-diastolic end-systolic volume indices compared to (p 0.011 p 0.013, respectively). Eleven (50%) LV systolic dysfunction (ejection fraction < 50%), most whom (8/11) non-ischaemic patterns LGE 7 mid-wall; n 1 mid-wall/patchy). In eleven preserved function ≥ three (27%) significant subepicardial/mid-wall; patchy). Compared controls, septal myocardial T1 values 0.001) but similar T2 0.090), suggesting presence fibrosis without oedema. Conclusions: by dilatation, dysfunction, in distribution. Significant oedema not prominent several weeks post-recovery. Further work needed test these findings on multi-centre basis develop novel therapies for cardiomyopathy.

Language: Английский

Characterisation of Post-Sepsis Cardiomyopathy Using Cardiovascular Magnetic Resonance DOI Creative Commons
Samuel Malomo, T Oswald, Edward R. Stephenson

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(8), P. 997 - 997

Published: April 14, 2025

Background: Post-sepsis cardiomyopathy is associated with an increased risk of adverse cardiovascular outcomes. It remains poorly understood, which limits therapeutic development. This study characterised post-sepsis using magnetic resonance (CMR) imaging. Methods: Patients admitted acute sepsis and suspected cardiac injury or heart failure who subsequently (47 days [IQR: 22-122]) underwent CMR at a UK tertiary centre were included. Age- gender-matched controls (n = 16) also Subjects 1.5 Tesla cines, native T1- T2-mapping, late gadolinium enhancement (LGE) Results: Of the 22 patients (age 50 ± 13 years; 64% males), (59%) had left ventricular (LV) dilatation. significantly elevated end-diastolic end-systolic volume indices compared to (p 0.011 p 0.013, respectively). Eleven (50%) LV systolic dysfunction (ejection fraction < 50%), most whom (8/11) non-ischaemic patterns LGE 7 mid-wall; n 1 mid-wall/patchy). In eleven preserved function ≥ three (27%) significant subepicardial/mid-wall; patchy). Compared controls, septal myocardial T1 values 0.001) but similar T2 0.090), suggesting presence fibrosis without oedema. Conclusions: by dilatation, dysfunction, in distribution. Significant oedema not prominent several weeks post-recovery. Further work needed test these findings on multi-centre basis develop novel therapies for cardiomyopathy.

Language: Английский

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