Left ventricular ejection time: its relation to left ventricular systolic function and functional capacity in cardiomyopathic patients DOI Creative Commons
Eman S. El Shahawy,

Asmaa A. Hassan

Al-Azhar Assiut Medical Journal, Journal Year: 2024, Volume and Issue: 22(2), P. 118 - 126

Published: April 1, 2024

Background and aim Left ventricular ejection time (LVET) was used to evaluate left function. Transthoracic echocardiogram done, parameters of LV systolic function by utilizing tissue Doppler imaging two-dimensional strain were obtained. Moreover, the New York Heart Association (NYHA) functional class 6 min walk test (6MWT) investigated intending detect LVET value in detection dysfunction patients with dilated cardiomyopathy (DCM) its relation a capacity assess clinical severity heart failure. Patients methods The enrolled 131 cases (101 myopathic 30 case as control). All do complete transthoracic dimensions, volumes, Parameters compared both groups. calculated, compared, correlated function, NYHA class, 6MWT. Results volumes DCM significantly elevated ( P <0.001), while their reduced. Additionally, cardiomyopathic group revealed significant reduction comparison control =0.002). correlates [LVEF M-mode r =0.01), LVEF =0.17), global longitudinal =0.09), velocity =0.20)]. Furthermore, connected 6MWT =−0.06, <0.0001, =0.04, =0.01, respectively). Conclusions In individuals having DCM, is simple valuable measure diagnose well it has potential implications for assessing

Language: Английский

Accuracy of the 6-Minute Walk Test for Assessing Functional Capacity in Patients With Heart Failure With Preserved Ejection Fraction and Other Chronic Cardiac Pathologies: Results of the ExIC-FEp Trial and a Meta-Analysis DOI Creative Commons
Iván Cavero‐Redondo, Alicia Saz‐Lara, Bruno Bizzozero‐Peroni

et al.

Sports Medicine - Open, Journal Year: 2024, Volume and Issue: 10(1)

Published: June 18, 2024

Abstract Background Heart diseases, particularly heart failure, significantly impact patient quality of life and mortality rates. Functional capacity assessment is vital for predicting prognosis risk in these patients. While the cardiopulmonary exercise test considered gold standard, 6-minute walk has emerged as a more accessible alternative. However, screening accuracy optimal cut-off points detecting severely reduced functional cardiac pathologies, including failure with preserved ejection fraction, are unclear. The study aimed to analyse diagnostic capacity, defined VO 2max < 14 ml/kg/min, compared participants fraction using data from “Ejercicio en Insuficiencia Cardiaca con Fracción de Eyección Preservada” (ExIC-FEp) trial; compare results previous studies investigating assessing other chronic pathologies through meta-analysis. Results ExIC-FEp trial involved 22 who were not treated beta-blockers, test, specifically 2max, reference test. had sensitivity 70%, specificity 80%, an area under curve 76% trial. Five included meta-analysis showing 79%, 78%, 85%. Conclusion In conclusion, holds promise tool ml/kg/min point. It demonstrates moderate good accuracy. regardless aetiology, Trial Registration NCT05726474. Registered 16 February 2023, https://clinicaltrials.gov/study/NCT05726474 .

Language: Английский

Citations

4
Cancer-Therapy-Related Cardiac Dysfunction: Latest Advances in Prevention and Treatment DOI Creative Commons
Carla Contaldi,

Carmine D’Aniello,

Domenico Panico

et al.

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 471 - 471

Published: March 15, 2025

The increasing efficacy of cancer therapies has significantly improved survival rates, but it also highlighted the prevalence cancer-therapy-related cardiac dysfunction (CTRCD). This review provides a comprehensive overview identification, monitoring, and management CTRCD, condition resulting from several treatments, such as anthracyclines, HER2-targeted therapies, target radiotherapy. paper includes discussion mechanisms CTRCD associated with various treatments. Early detection through serum biomarkers advanced imaging techniques is crucial for effective monitoring risk stratification. Preventive strategies include pharmacological interventions ACE inhibitors/angiotensin receptor blockers, beta-blockers, statins. Additionally, novel agents like sacubitril/valsartan, sodium-glucose co-transporter type 2 inhibitors, vericiguat show promise in managing left ventricular dysfunction. Lifestyle modifications, including structured exercise programs optimized nutritional strategies, further contribute to cardioprotection. latest treatments both asymptomatic symptomatic across its stages are discussed. Emerging technologies, genomics, artificial intelligence, biomarkers, gene therapy, paving way personalized approaches prevention treatment. These advancements hold great improving long-term outcomes patients by minimizing cardiovascular complications.

Language: Английский

Citations

0
Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice DOI Creative Commons
Nabil V. Sayour, Dániel Kucsera,

Abdulaziz AlHaddad

et al.

Basic Research in Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Despite accumulating data on underlying mechanisms, the influence of sex and prevalent cardio-metabolic co-morbidities manifestation severity immune checkpoint inhibitor (ICI)-induced cardiotoxicity has not been well defined. To elucidate whether affect ICI-induced cardiotoxicity, we randomized 17-month-old male female mice to receive control diet (CON) or high-fat (HFD) + L-NAME-a well-established mouse model co-morbidities-for 17 weeks (n = 5-7), evaluated markers T-cell function in spleen. As expected, HFD L-NAME significantly increased body- heart weight, serum cholesterol levels, caused no systolic dysfunction, however, led diastolic cardiomyocyte hypertrophy, fibrosis only males compared corresponding CON. Western blot analyses splenic protein levels showed differential expression depending co-morbidities, suggesting exhaustion both sexes L-NAME, but more pronounced males. In a sub-study with similar setup, tested cardiotoxic manifestations ICI by treating anti-PD-1 monoclonal antibody (ICI) for last 2 administration 5-7). After treatment, cardiac functions decreased CON, groups baseline (before administration). conclusion, this exploratory study using aged mice, describe first time that ICI-related dysfunction is diminished when obesity hypercholesterolemia are present, possibly due obesity-related exhaustion.

Language: Английский

Citations

3
Cardiovascular mortality in people with cancer compared to the general population: A systematic review and meta‐analysis DOI Creative Commons
Huah Shin Ng, Xingqiong Meng, Tania Marin

et al.

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(15)

Published: Aug. 1, 2024

Abstract Background Cardiovascular disease (CVD) is the leading cause of non‐cancer death in cancer survivors, but risk CVD varies between cancers. Objectives To synthesise available evidence on patterns and magnitude mortality risk. Methods A systematic search Medline (OVID), CINAHL Scopus databases from 01‐January‐2000 to 16‐July‐2023 studies people with cancer, reporting population compared a reference (e.g. general population) as standardised ratios (SMR). Meta‐analysis SMRs across types were pooled using random‐effects model allow for heterogeneity true effect size studies. Results We identified 136 16 countries. Sample sizes ranged 157 7,529,481. The majority ( n = 98; 72%) conducted United States, followed by Europe 22; 16%). most common cancers studied gastrointestinal 34 studies), haematological 31) breast 29). total 876 extracted diverse conditions. Of those, (535; 61%) indicated an increased (SMR >1), 109 (12%) lower <1) 232 (27%) equivalent (95% CI SMR included 1) population. meta‐analysis all reported showed 1.55, 95% 1.40–1.72) survivors varied conditions 1.36 1.29–1.44) heart diseases 1.56 1.39–1.76) cerebrovascular diseases. types, ranging 1.14 1.04–1.25) testicular/germ cell tumours 2.82 2.20–3.63) brain/central nervous system tumours. Conclusions Cancer are at premature population, type CVD. Future research should focus understanding mechanisms behind develop appropriate interventions.

Language: Английский

Citations

2
Cardioprotection of voluntary exercise against breast cancer-induced cardiac injury via STAT3 DOI
Lan Wu, Zhi‐Zheng Li, Hao Yang

et al.

Basic Research in Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

Language: Английский

Citations

1
Prehabilitation for patients undergoing neoadjuvant therapy prior to cancer resection: a systematic review and meta-analysis DOI
Ye Chen, Raquel Sebio,

Edgar Iglesias-Garcia

et al.

Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(11)

Published: Oct. 28, 2024

Language: Английский

Citations

1
A Lived Experience of an Accredited Exercise Physiologist with Breast Cancer—A Unique Perspective of Exercise DOI
Melissa J. Pearson, Neil A. Smart, Gudrun Dieberg

et al.

Journal of Clinical Exercise Physiology, Journal Year: 2024, Volume and Issue: 13(3), P. 100 - 110

Published: Aug. 23, 2024

Language: Английский

Citations

0
Left ventricular ejection time: its relation to left ventricular systolic function and functional capacity in cardiomyopathic patients DOI Creative Commons
Eman S. El Shahawy,

Asmaa A. Hassan

Al-Azhar Assiut Medical Journal, Journal Year: 2024, Volume and Issue: 22(2), P. 118 - 126

Published: April 1, 2024

Background and aim Left ventricular ejection time (LVET) was used to evaluate left function. Transthoracic echocardiogram done, parameters of LV systolic function by utilizing tissue Doppler imaging two-dimensional strain were obtained. Moreover, the New York Heart Association (NYHA) functional class 6 min walk test (6MWT) investigated intending detect LVET value in detection dysfunction patients with dilated cardiomyopathy (DCM) its relation a capacity assess clinical severity heart failure. Patients methods The enrolled 131 cases (101 myopathic 30 case as control). All do complete transthoracic dimensions, volumes, Parameters compared both groups. calculated, compared, correlated function, NYHA class, 6MWT. Results volumes DCM significantly elevated ( P <0.001), while their reduced. Additionally, cardiomyopathic group revealed significant reduction comparison control =0.002). correlates [LVEF M-mode r =0.01), LVEF =0.17), global longitudinal =0.09), velocity =0.20)]. Furthermore, connected 6MWT =−0.06, <0.0001, =0.04, =0.01, respectively). Conclusions In individuals having DCM, is simple valuable measure diagnose well it has potential implications for assessing

Language: Английский

Citations

0