The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology DOI Creative Commons
Roberta Amoriello, Christian Memo, Laura Ballerini

et al.

Molecular Brain, Journal Year: 2024, Volume and Issue: 17(1)

Published: Jan. 23, 2024

Abstract The central nervous system (CNS) is finely protected by the blood–brain barrier (BBB). Immune soluble factors such as cytokines (CKs) are normally produced in CNS, contributing to physiological immunosurveillance and homeostatic synaptic scaling. CKs peptide, pleiotropic molecules involved a broad range of cellular functions, with pivotal role resolving inflammation promoting tissue healing. However, pro-inflammatory can exert detrimental effect pathological conditions, spreading damage. In inflamed recruit immune cells, stimulate local production other inflammatory mediators, promote dysfunction. Our understanding neuroinflammation humans owes much study multiple sclerosis (MS), most common autoimmune demyelinating disease, which autoreactive T cells migrate from periphery CNS after encounter still unknown antigen. CNS-infiltrating produce that aggravate demyelination neurodegeneration. This review aims recapitulate state art about healthy focus on recent advances bridging adaptive neurophysiology.

Language: Английский

The second decade of anti-TNF-a therapy in clinical practice: new lessons and future directions in the COVID-19 era DOI Open Access
Gerasimos Evangelatos, Giorgos Bamias, George D. Kitas

et al.

Rheumatology International, Journal Year: 2022, Volume and Issue: 42(9), P. 1493 - 1511

Published: May 3, 2022

Language: Английский

Citations

62
TNF plays a crucial role in inflammation by signaling via T cell TNFR2 DOI Open Access

Muhammad S. Alam,

Shizuka Otsuka,

Nathan Wong

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(50)

Published: Dec. 6, 2021

Significance Inflammatory diseases are mediated by products such as TNF and IL-17 produced T helper (Th) cell subsets. Here, we identify a direct role for in the production of pathogenic cells, particularly cells that produce (Th17) interferon-γ (Th1). We found shapes inflammatory response signaling via its relatively unstudied “minor” receptor, TNFR2, skewing to become Th17 enhancing cytokine Th1 cells. Preventing TNFR2 resulted reduced disease mouse models multiple sclerosis colitis. This work integrates importance with Th17/Th1 pathogenicity may explain paradox IL-17–dependent diseases, psoriasis ankylosing spondylitis, respond anti-TNF monotherapy.

Language: Английский

Citations

56
NF-κB Signaling and Inflammation—Drug Repurposing to Treat Inflammatory Disorders? DOI Creative Commons
Annabell Roberti, Laura Elizabeth Chaffey, David R. Greaves

et al.

Biology, Journal Year: 2022, Volume and Issue: 11(3), P. 372 - 372

Published: Feb. 26, 2022

NF-κB is a central mediator of inflammation, response to DNA damage and oxidative stress. As result its role in so many important cellular processes, dysregulation has been implicated the pathology human diseases. activation causes inappropriate inflammatory responses diseases including rheumatoid arthritis (RA) multiple sclerosis (MS). Thus, modulation signaling being widely investigated as an approach treat chronic diseases, autoimmunity cancer. The emergence COVID-19 late 2019, subsequent pandemic huge clinical burden patients with life-threatening SARS-CoV-2 pneumonia led massive scramble repurpose existing medicines lung inflammation wide range healthcare systems. These efforts continue have proven be controversial. Drug repurposing strategies are promising alternative de novo drug development, they minimize development timelines reduce risk failure due unexpected side effects. Different experimental approaches applied identify which inhibit that could repurposed anti-inflammatory drugs.

Language: Английский

Citations

50
Immune System Dysregulation in the Progression of Multiple Sclerosis: Molecular Insights and Therapeutic Implications DOI
Zuber Khan, Sidharth Mehan, Ghanshyam Das Gupta

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 548, P. 9 - 26

Published: April 30, 2024

Language: Английский

Citations

13
The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology DOI Creative Commons
Roberta Amoriello, Christian Memo, Laura Ballerini

et al.

Molecular Brain, Journal Year: 2024, Volume and Issue: 17(1)

Published: Jan. 23, 2024

Abstract The central nervous system (CNS) is finely protected by the blood–brain barrier (BBB). Immune soluble factors such as cytokines (CKs) are normally produced in CNS, contributing to physiological immunosurveillance and homeostatic synaptic scaling. CKs peptide, pleiotropic molecules involved a broad range of cellular functions, with pivotal role resolving inflammation promoting tissue healing. However, pro-inflammatory can exert detrimental effect pathological conditions, spreading damage. In inflamed recruit immune cells, stimulate local production other inflammatory mediators, promote dysfunction. Our understanding neuroinflammation humans owes much study multiple sclerosis (MS), most common autoimmune demyelinating disease, which autoreactive T cells migrate from periphery CNS after encounter still unknown antigen. CNS-infiltrating produce that aggravate demyelination neurodegeneration. This review aims recapitulate state art about healthy focus on recent advances bridging adaptive neurophysiology.

Language: Английский

Citations

11