Global, regional, and national burden and trends of migraine among women of childbearing age from 1990 to 2021: insights from the Global Burden of Disease Study 2021

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: June 6, 2024

Abstract Background Migraine, a neurological disorder with significant female predilection, is the leading cause of disability-adjusted life years (DALYs) in women childbearing age (WCBA). There currently lack comprehensive literature analysis on overall global burden and changing trends migraines WCBA. Methods This study extracted three main indicators, including prevalence, incidence, DALYs, related to migraine WCBA from Global Burden Disease(GBD) database 1990 2021. Our presented point estimates 95% uncertainty intervals (UIs). It evaluated using estimated annual percentage change (EAPC) change. Results In 2021, DALYs cases among were 493.94 million, 33.33 18.25 respectively, changes 48%, 43%, 47% compared 1990. Over past 32 years, prevalence rates globally have increased, an EAPC 0.03 (95% UI: 0.02 0.05) 0.04 0.05), while incidence decreased -0.07 -0.08 -0.05). Among 5 Socio-Demographic Index (SDI) regions, middle SDI region recorded highest WCBA, at 157.1 10.56 5.81 approximately one-third total. terms age, for group 15–19 5942.5 thousand, rate per 100,000 population 1957.02, all groups. The total number show increasing trend particularly 45–49 group. Conclusions Overall, has significantly increased over within Research findings emphasize importance customized interventions aimed addressing issue thus contributing attainment Sustainable Development Goal 3 set by World Health Organization.

Language: Английский

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Evaluation of outcomes of calcitonin gene-related peptide (CGRP)-targeting therapies for acute and preventive migraine treatment based on patient sex

Cephalalgia, Journal Year: 2024, Volume and Issue: 44(3)

Published: March 1, 2024

Background Women show increased prevalence and severity of migraine compared to men. Whether small molecule calcitonin gene-related peptide receptor (CGRP-R) antagonists (i.e., gepants) monoclonal antibodies targeting either the CGRP-R or CGRP might sexually dimorphic outcomes for acute preventive therapy has not been established. Methods We conducted a subpopulation analysis available published data from FDA reviews evaluate potential sex differences in response rates ubrogepant, rimegepant zavegepant therapy. Available erenumab, fremanezumab, galcanezumab eptinezumab, approved atogepant were examined prevention based on patient sex. Preventive analyzed separately patients with episodic chronic migraine. Results In women, three gepants produced statistically significant drug effects regardless dose tested mandated co-primary endpoints, proportion achieving two-hour pain-freedom free their most bothersome symptom at two hours post-dose. average placebo-subtracted was 9.5% (CI: 7.4 11.6) numbers needed treat 11. The also women. gepant drugs did reach endpoint men, an effect 2.8% −2.5 8.2) number 36. For freedom post-dose endpoint, male patients. treatment each studies always numerically greater women than evaluation using change specified primary (e.g., monthly days), observed almost favored over placebo both similar men treated group. Conclusion/Interpretation: Small are effective but do demonstrate effectiveness CGRP-targeting therapies female possible remain uncertain. patients, CGRP/CGRP-R similarly effective. highlight differential targeted different populations need understanding neurobiology

Language: Английский

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Female-selective mechanisms promoting migraine

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: April 24, 2024

Sexual dimorphism has been revealed for many neurological disorders including chronic pain. Prelicinal studies and post-mortem analyses from male female human donors reveal sexual of nociceptors at transcript, protein functional levels suggesting different mechanisms that may promote pain in men women. Migraine is a common female-prevalent disorder characterized by painful debilitating headache. Prolactin neurohormone circulates higher females implicated clinically migraine. sensitizes sensory neurons mice, non-human primates humans revealing female-selective mechanism conserved evolutionarily likely translationally relevant. produces migraine-like behaviors rodents enhances the release calcitonin gene-related peptide (CGRP), neurotransmitter causal promoting migraine patients. CGRP, like prolactin, behaviors. Consistent with these observations, publicly available clinical data indicate small molecule CGRP-receptor antagonists are preferentially effective treatment acute therapy Collectively, observations support conclusion qualitative sex differences providing opportunity to tailor therapies based on patient improved outcomes. Additionally, should be considered design trials as well reassessment past warranted.

Language: Английский

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Disease burden of migraine and tension-type headache in non-high-income East and Southeast Asia from 1990 to 2019

The Journal of Headache and Pain, Journal Year: 2023, Volume and Issue: 24(1)

Published: March 26, 2023

Abstract Background The world faces severe challenges from migraine and tension-type headache (TTH), which cause grave disability to patients place a heavy burden on their caregivers. However, headaches in specific individual regions have rarely been investigated. Therefore, we aimed fully analyse describe the current status changing trends TTH non-high-income East Southeast Asia provide more detailed real-world information for policy-making. Methods data used analysis were all extracted Global Burden of Disease (GBD) database. We adopted three major indicators disease burden, including prevalence, incidence, years lived with (YLD), two metrics, absolute number age-standardized rate, our present study further evaluation by age sex. results are presented form mean values 95% uncertainty intervals (UIs). In addition, differences between other regions, as well potential associations socioeconomic background, explored. Results 2019, approximately 195,702,169 291,924,564 Asia, 113,401,792 179,938,449 Asia. terms countries highest YLD rate (ASYR) was Thailand [645 (95% UI: 64 1,554)]. ASYR Indonesia [54 15 197)]. Furthermore, people ages 40 44, especially females, identified main population that suffered TTH. Unfortunately, did not observe significant association background. Conclusions To date, threats still serious ongoing, leading prominently negative impacts daily life work local residents. full attention sound guidelines urgently needed obtain greater advantages fighting against disorders future.

Language: Английский

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The prevalence and demographic associations of headache in the adult population of Benin: a cross-sectional population-based study

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: April 5, 2024

Abstract Background The Global Burden of Disease (GBD) study is increasingly well informed with regard to headache disorders, but sub-Saharan Africa (SSA) remains one the large regions world limited data directly derived from population-based studies. Campaign against Headache has conducted three studies in this region: Ethiopia east, Zambia south and Cameroon Central SSA. Here we report a similar Benin, first West Methods We used same methods questionnaire, applying cluster-randomized sampling country, randomly selecting households each region, visiting these unannounced adult member (aged 18–65 years) household. HARDSHIP structured translated into African French, was administered face-to-face by trained interviewers. Demographic enquiry followed diagnostic questions based on ICHD-3 criteria. Results From 2,550 eligible members, recruited 2,400 participants (participating proportion 94.1%). ever reported almost all (95.2%), being lifetime prevalence. last year 74.9%. Age-, gender- habitation-adjusted estimates 1-year prevalence were 72.9% for headache, 21.2% migraine (including definite probable), 43.1% TTH (also including 4.5% probable medication-overuse (pMOH) 3.1% other ≥ 15 days/month. One-day (point) 14.8% according day preceding interview. Conclusions Overall, findings are evidence that disorders very common low-income country. pMOH, above estimated global mean 1–2%, poverty not bar medication overuse. much as those its near neighbour, Cameroon. With migraine, they reasonably accord two earlier selected Beninese populations, which did take account migraine. This adds hitherto knowledge

Language: Английский

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Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(15), P. 2803 - 2814

Published: March 10, 2023

The detection of environmental temperatures is critical for survival, yet inappropriate responses to thermal stimuli can have a negative impact on overall health. physiological effect cold distinct among somatosensory modalities in that it soothing and analgesic, but also agonizing the context tissue damage. Inflammatory mediators produced during injury activate nociceptors release neuropeptides, such as calcitonin gene-related peptide (CGRP) substance P, inducing neurogenic inflammation, which further exasperates pain. Many inflammatory induce sensitization heat mechanical but, conversely, inhibit responsiveness, identity molecules pain peripherally enigmatic, are cellular molecular mechanisms altering sensitivity. Here, we asked whether inflammation via nociceptive ion channels TRPV1 (vanilloid subfamily transient receptor potential channel) TRPA1 (transient ankyrin 1) lead mice. Specifically, tested sensitivity mice after intraplantar injection lysophosphatidic acid or 4-hydroxy-2-nonenal, finding each induces dependent cold-gated channel melastatin 8 (TRPM8). Inhibition CGRP, toll-like 4 (TLR4) signaling attenuates this phenotype, neuropeptide produces TRPM8-dependent directly. Further, inhibition CGRP TLR4 alleviates allodynia differentially by sex. Last, induced both neuropeptides requires TRPM8, well neurotrophin artemin its GDNF α3 (GFRα3). These results consistent with artemin-induced requiring demonstrating alters localized GFRα3 TRPM8.SIGNIFICANCE STATEMENT generate complex diverse array pain-producing generated act sensitize peripheral sensory neurons, thereby Here identify specific neuroinflammatory pathway involving TRPM8 cation M member 8) (GDNF α3) leads pain, providing select targets therapies modality.

Language: Английский

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Neurological care for LGBT+ people

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(5), P. 288 - 297

Published: March 18, 2024

Language: Английский

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The Global Burden of Migraine: A 30-Year Trend Review and Future Projections by Age, Sex, Country, and Region

Pain and Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract Introduction Migraine is a prevalent neurological disorder causing significant disability worldwide. Despite extensive research on specific populations, comprehensive analyses of global trends are remains limited. Methods We extracted incidence, prevalence, and disability-adjusted life years (DALYs) data for migraine from the Global Burden Disease 2021 database. Trends were analyzed across regions, age groups, sexes, sociodemographic index (SDI) using estimated annual percentage changes (EAPC). Predictive models (ARIMA) used to forecast 2050. Results From 1990 2021, burden significantly increased: prevalence increased by 58.15%, 732.56 million 1.16 billion cases, incidence 42.06%. The DALYs also 58.27%. There differences between sexes: female individuals had higher absolute rates but male exhibited four- five-fold more rapid increase than in these parameters. Adolescents (< 20 old) have fastest growth DALYs. Regionally, high SDI regions having highest age-standardized rate (ASR) low lowest ASR East Asia Latin America most increases burden, whereas Southeast pronounced decrease. analysis suggests will continue rise until 2050, particularly among adolescents. Conclusions has escalated with bearing greater showing faster rate. face rapidly rising prevalence. Disparities countries, sexes emphasize need targeted public health strategies. Focused interventions required mitigate growing impact migraines health,

Language: Английский

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Migraine in men

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 3, 2025

Migraine is a common primary headache disorder, less frequently affecting men than women, and often regarded as predominantly "women's disease." Despite this, migraine in presents with unique characteristics terms of symptoms, treatment responses, comorbidities, pain perception. Historically, research has focused more on overlooking critical male-specific aspects. This review delves into the epidemiology, clinical presentation, particular challenges diagnosing managing men. It addresses sex-specific triggers, hormonal influences, comorbid conditions prevalence severity Additionally, evaluates current therapeutic strategies, underscoring necessity for individualized approaches. Men exhibit atypical symptoms compared to ICHD-3 criteria are likely report associated symptoms. They also tend have fewer psychological respond favorably pharmacological treatments, yet seek medical support. The reasons these sex disparities complex, involving biological, psychosocial, cultural factors, such brain structural differences, differences functional responses painful stimuli, effects, behavioral influences like adherence masculine norms stigma. underrepresented research. In contrast, preclinical studies focus solely male animals result various misconceptions. disparity necessitates greater aspects enhance diagnosis, treatment, Addressing stigma, increasing healthcare access, ensuring balanced gender representation future crucial comprehensive understanding effective management all patients.

Language: Английский

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Can Headache Be a Symptom of Celiac Disease?: A University Hospital Experience

Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, Journal Year: 2025, Volume and Issue: 15(1), P. 323 - 329

Published: Jan. 29, 2025

Aim: The purpose of this study was to determine the prevalence Celiac disease in pediatric patients presenting with headache. However, little is known about co-morbidity and To our knowledge, first prospective that systematically reviews topic. Method: Two hundred forty four referred Pediatric neurology clinic Adıyaman University Training Research Hospital between January 2021 November 2022 were examined. Gender, age, type headache, serology, other laboratory parameters cases meeting inclusion criteria recorded. Upper gastrointestinal endoscopy performed on positive serology. Patients whose results compatible placed a gluten-free diet. Results: group consisted 202 patients, 123 girls (60.9%). patients’ mean age 12.67±3.524 years. Tension-type headache determined 121 (59.9%) patient group, migraine 81 (40.1%). detected 5.4%. Vitamin B12 211±79.1 pg/ml, ferritin 19.5±13.9 ng/mL, vitamin D 17.6±9.86 ng/ml (n=193). Interestingly, all who diagnosed reported complaints decreased diet, no statistically significant correlation found any finding type. Conclusion: Although it still controversial whether common children celiac disease, showed neurological symptoms improved after diet disease. should be investigated persistent despite pharmacological treatment.

Language: Английский

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