Overcoming obstacles to effective treatment of patients with migraine (Statement of the expert group on optimizing treatment of patients with migraine)

Neurology neuropsychiatry Psychosomatics, Journal Year: 2025, Volume and Issue: 17(2), P. 4 - 14

Published: April 21, 2025

Despite the development of basic principles and a wide arsenal therapeutic preventive agents, effective treatment migraine patients in daily practice is associated with some well-identified obstacles. Among many obstacles to treatment, several key factors can be identified: low patients' awareness nature disease, its course prognosis, methods prevention, rate referral for medical care unsatisfactory level diagnosis clinical practice, inadequate training physicians field headache, nonoptimal use symptom management strategies. The article discusses most common problems strategies optimize patients.

Language: Английский

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Headache and Facial Pain in Multiple Sclerosis: A Narrative Review

Clinical and Translational Neuroscience, Journal Year: 2025, Volume and Issue: 9(1), P. 16 - 16

Published: March 6, 2025

Headache and facial pain syndromes are frequently observed in people with multiple sclerosis (MS), often affecting young adults during pivotal stages of their lives. These conditions can disrupt ability to work, maintain relationships, engage daily activities, leading significant socio-economic personal challenges. This narrative review summarizes key epidemiological data diagnostic insights into headache disorders MS. It addresses the complexities diagnosing these overlapping highlights specific therapeutic considerations.

Language: Английский

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A Correlation Between Migraine and Endometriosis and Its Clinical Implications—A Systematic Literature Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2744 - 2744

Published: April 16, 2025

Background/Objectives: Migraine and endometriosis are two diseases that associated with women. Endometriosis is a condition exclusively affecting the female population as it affects genital tract, while migraine primary headache disorder having highest prevalence in women of reproductive age. Although, undoubtedly, they distinct disorders, some correlations have been suggested considering epidemiological similarities. Methods: This systematic review aimed to analyze putative links between those diseases. Two databases were searched accordance PRISMA guidelines, which led inclusion 28 most appropriate studies. The was registered PROSPERO. Results: A comprehensive analysis existing literature allowed us distinguish six different aspects: (i) course endometriosis, general, (ii) when comparing patients healthy individuals, (iii) relation types (iv) pain symptoms migraine, finally, (v) molecular (vi) genetic bases suspected correlation. Conclusions: Although not all results definitely apparent, showed higher together than both separately. More precisely, chronic demonstrated be possibly linked endometriosis. Moreover, usually more evident suffering from at time. Finally, suggestions presented due this comorbidity’s bases; however, literature, especially on topic, lacking.

Language: Английский

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Enhancement of the endocannabinoid system through monoacylglycerol lipase inhibition relieves migraine-associated pain in mice

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 18, 2025

Migraine affects over 1 billion people worldwide and is a leading cause of disability. Targeting the cannabinoid system offers promising approach for pain migraine relief. This study evaluated novel monoacylglycerol lipase (MAGL) inhibitor to prolong endocannabinoid action in acute chronic mouse models migraine. It also examined MAGL receptor (CB1) mRNA expression key head pain-processing regions. C57BL6/J male female mice received human trigger nitroglycerin (NTG) acutely or every other day 9 days. Allodynia was assessed by von Frey hair stimulation periorbital area. A single dose (ABD-1970) tested NTG models. Additionally, ABD-1970 given daily 5 days assess tolerance. In situ hybridization measured transcript MAGL, CB1, neuronal marker Rbfox3 trigeminal ganglia (TG) nucleus caudalis (TNC). injection blocked cephalic allodynia induced NTG. established intermittent Repeated administration did not induce tolerance, continued block NTG-induced after administration. There high CB1 TG TNC, present positive negative cells. effectively migraine-associated pain, likely through prolonged action. effect may be mediated at peripheral central sites considering respectively. The appears modulate mechanisms, target this disorder.

Language: Английский

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