Medication overuse in patients with migraine: Severity of dependence and personality characteristics

Cephalalgia Reports, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Introduction Factors associated with the development of medication overuse (MO) are not fully understood. The aim this article is to investigate whether patients diagnosed migraine and without MO differed in personality characteristics. Methods study was a single-center observational migraine, as defined by International Classification Headache Disorders III (ICHD-III). After written consent, were given access an online survey. Scores obtained Severity Dependence Scale (SDS) NEO Five-Factor Inventory (NEO-FFI), namely openness experience, conscientiousness, extraversion, agreeableness, neuroticism, from both compared applying Mann–Whitney U-test. Results A total 128 completed survey, which 46 (35.9%) analgesic overuse. Patients significantly older (41.2 ± 8.6 vs. 37.5 11.4, p = 0.015), while percentage female equivalent between groups (73.3% 86.4%, 0.068). Migraine reported more frequent past or current visits mental care providers (52.2% 29.4%, 0.015). SDS comparable (2.8 3.8 2.3 2.9, 0.756). scored higher on agreeableness ( 0.016). No differences observed regarding remaining Conclusions likely report health those MO. Differences traits minimal, only being

Language: Английский

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Trends in migraine and tension-type headaches in South Asia: findings from the Global Burden of Disease Study 2021 (1990–2021)

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

Headache disorders, including migraines and tension-type headaches (TTH), are major contributors to global disability. In South Asia, where these conditions often underdiagnosed, their burden has grown substantially. This study evaluates trends in headache disorders across eight Asian countries from 1990 2021, using data the Global Burden of Disease (GBD) Study 2021. Data GBD were analysed evaluate incidence, prevalence, years lived with disability (YLDs) for subtypes. Trends assessed absolute numbers age-standardized rates, demographic patterns by age gender examined identify vulnerable populations. Joinpoint regression analysis was employed detect significant temporal shifts. From Asia rose 114.2 million 206.8 367.4 698.5 YLDs nearly doubling 6.0 11.6 million. Migraines accounted 294.4 cases, while TTH contributed 495.4 increasing 92.88 99.35%, respectively. Afghanistan saw highest relative growth, India largest burden. Women middle-aged adults disproportionately affected, prevalence observed females aged 30-34 years. The Maldives showed dramatic increases TTH-related YLDs, highlighting disparities smaller nations. rising highlights need region-specific strategies targeting high-burden subtypes, countries, populations mitigate disabling impacts.

Language: Английский

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Prevalence and relative frequency of cervicogenic headache in population- and clinic-based studies: A systematic review and meta-analysis

Cephalalgia, Journal Year: 2025, Volume and Issue: 45(3)

Published: March 1, 2025

Background Cervicogenic headache is a rare disorder which garnering increasing clinical and research interest, but whose prevalence phenotype surrounded by uncertainty. We found it timely to systematically appraise the current literature on prevalence, relative frequency, features of cervicogenic in population- clinic-based settings. Methods PubMed Embase were searched for observational, studies published between 1 January 1942 3 September 2024 that reported frequency headache, diagnosed according International Classification Headache Disorders. The titles, abstracts, full text-articles screened two independent investigators. To estimate pooled across clinic- population-based studies, random-effects meta-analyses conducted. study was pre-registered PROSPERO (identifier: CRD42024498128) accordance with Guidelines Meta-Analyses Observational Studies Epidemiology. Results Three met inclusion criteria from Disorders diagnosing headache. One reporting among adult patients who evaluated tertiary care unit. one population 3.9% females representing 77.8% those affected. In be 3.1% (95%, CI, 2.6–3.8) amongst outpatient 3165 women 80.8% 71.9–87.4). Conclusions Based this meta-analysis, data are limited. scarcity stresses need further into diagnostic criteria, its position

Language: Английский

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Analysis of headache burden Chinese in the global context from 1990 to 2021

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Headache is one of the leading causes disability in worldwide and China, second most burden disease nervous system after stroke. We aimed to analyze global trends headache disorders, migraine TTH among people China an international context. Data were taken from Global Burden Disease (GBD) Study 2021 database examine incidence, prevalence, disability-adjusted life year disorders. In context a large scale world, currently state high incidence female middle-aged young patients are main body this disease. Need focus on vulnerable population while formulating effective health policies developing good treatment measures reduce disorders improve DALYs rate headache.

Language: Английский

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Headache in transgender men using gender‐affirming hormone therapy: A case–control study

Headache The Journal of Head and Face Pain, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Objectives This study aimed to compare the frequency, characteristics, and impact of primary headaches in transgender men (TM), cisgender (CM), women (CW). Background Gender is a social construct shaped by roles norms influenced cultural environmental factors. Studies on typically only consider sex generally overlook gender. Methods was case–control conducted at Hospital das Clínicas, Universidade Federal de Pernambuco, Brazil. A pilot comparing 25 TM CM individuals determine sample size requirements. After that, 50 (cases), (controls), CW (controls) were included. The controls age matched cases. semi‐structured questionnaire, six‐item Headache Impact Test (HIT‐6), Anxiety Depression Scale used. Data collection occurred from April 2022 November 2023. Results All taking gender‐affirming hormone therapy (testosterone cypionate, 41; testosterone undecanoate/undecylenate, six; esters, three). According calculation, adequate power achieved for frequency tension‐type headache (TTH) impact. No differences observed between migraine (odds ratio [OR] 1.14, 95% confidence interval [CI] 0.45–2.91), TTH (OR 0.74, CI 0.28–1.96), or severity (frequency ≥8 days/month: OR 0.54; 1.18–1.63; moderate/severe intensity: 1.24, 0.49–3.18; HIT‐6 score ≥56 points: 0.66, 0.25–1.75) adjusted higher education depression conditional logistic regression). group exhibited significantly lower rates all types 0.20, 0.05–0.85) 0.18, 0.07–0.45) prevalence any 3.93, 1.60–9.63) without aura 3.12, 1.10–8.84) compared anxiety There no (frequency, intensity, impact). Conclusions are type groups. have than CM, but difference severity.

Language: Английский

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Headache disorders and relevant sex and socioeconomic patterns in adolescents and young adults across 204 countries and territories: an updated global analysis

The Journal of Headache and Pain, Journal Year: 2023, Volume and Issue: 24(1)

Published: Aug. 17, 2023

Primary headache disorders are a group of highly prevalent and disabling neurological diseases that mainly consist migraine tension-type (TTH). A previous study showed the burden headaches peaked at working age ranged from 15 to 49, particularly among females, affecting their productivity severely damaging social interactions.The latest dataset was retrieved Global Burden Disease (GBD) Study 2019. Three indicators, including prevalence, incidence, years lived with disability (YLDs), were adopted for evaluation. The overall specific burdens fully compared analysed global, regional, national levels. ratio female YLD rates male due calculated estimate sex pattern. Finally, we utilized two-tailed Spearman test explore potential association between socioeconomic background young people.Globally, disorders, total 2,049,979,883 cases (95% uncertainty interval (UI): 1,864,148,110 2,239,388,034), 601,229,802 incident UI: 530,329,914 681,007,934), 38,355,993 YLDs 7,259,286 83,634,503) observed those aged 10 54 in Sex differences widely found all types adolescents adults, especially migraine. However, most interesting finding associations tested environment patients positive, regardless region or country territory.Overall, global adults largely increased 1990 Although slight declines differences, they remained significant challenging. positive correlations people relatively inconsistent investigations, several related hypotheses proposed explanation. Interdisciplinary actions involving education, policy- law-making, basic medical practice desperately needed further fight against burden, promote gender equality care, eliminate stigmatization student groups.

Language: Английский

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Neurological Health in Sexual and Gender Minority Individuals

Seminars in Neurology, Journal Year: 2024, Volume and Issue: 44(02), P. 193 - 204

Published: March 14, 2024

Abstract Despite representing a significant proportion of the U.S. population, there is paucity population-based research on health status and needs sexual gender minority (SGM) individuals in neurology. Compared with heterosexual peers, some SGM populations have higher burden chronic conditions. In parallel, are more likely to experience stigma discrimination producing psychological distress, which may contribute be compounded by reduced care access utilization. this narrative review, we summarize existing literature common neurological conditions such as stroke, headache, epilepsy, movement disorders, traumatic brain injury through lens intersection identity. Special focus attuned social determinants gender-affirming hormonal therapy. Given limitations available literature, an urgent unmet need for datasets that include orientation identity information, well funding will characterize prevalence conditions, unique risk factors, outcomes populations. community, providers should address deficiencies their professional training integrate inclusive language into clinical skillset build trust patients. There opportunity neurology proactively engage communities, collaborate remove barriers care, promote resilience, develop targeted interventions ensure high-quality, culturally competent improve all.

Language: Английский

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Biocompatible Fe-Based Metal-Organic Frameworks as Diclofenac Sodium Delivery Systems for Migraine Treatment

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(23), P. 12960 - 12960

Published: Dec. 4, 2023

Migraine is now the sixth most common disease in world and affects approximately 15% of population. Non-steroidal anti-inflammatory drugs, including ketoprofen, diclofenac sodium, ibuprofen, are often used during migraine attacks. Unfortunately, their efficiency can be reduced due to poor water solubility low cellular uptake. This requires design appropriate porous carriers, which enable drugs reach target site, increase dissolution stability, contribute a time-dependent specific release mode. In this research, potential MIL-88A metal-organic frameworks with divergent morphologies as sodium delivery platforms was demonstrated. Materials were synthesized under different conditions (temperature: 70 120 °C; solvent: distilled or N,N-Dimethylformamide) characterized using X-ray diffraction, low-temperature nitrogen adsorption/desorption, thermogravimetric analysis, infrared spectroscopy, scanning electron microscopy. They showed spherical, rod- diamond-like influenced by preparation factors. Depending on physicochemical properties, samples exhibited various sorption capacities toward (833–2021 mg/g). Drug adsorption onto surface materials primarily relied formation hydrogen bonds, metal coordination, electrostatic interactions. An vitro drug experiment performed at pH 6.8 revealed that diffused phosphate buffer controlled manner. The carriers provide high percentage range 58–97% after 24 h.

Language: Английский

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The role of androgens in migraine pathophysiology

Neurobiology of Pain, Journal Year: 2024, Volume and Issue: 16, P. 100171 - 100171

Published: July 1, 2024

Migraine affects ∼12 % of the worldwide population and is more prevalent in females, which suggests a role sex hormones migraine pathophysiology. Most studies have focused on estrogen progesterone, involvement androgens has been less studied. However, due to recent advances androgen interventions, could advance new androgen-based treatments, it critical better understand migraine. Testosterone, most studied androgen, was found an antinociceptive effect various animal human pain studies. Thus, also protective related lower severity prevalence. In this review, we discuss examining migraine-related symptoms models. Additionally, summarize results comparing levels between patients with healthy controls, assessing relationships severity, intervention impact testosterone treatment severity. Many limitations, however, suggest that may minor Still, possible are involved pathophysiology sub-group such as adolescents or postmenopausal women. We potential mechanisms testosterone, main tested, can These range from cellular level systems behavior include sensory neurons, immune vascular systems, stress response, brain function, mood. Lastly, future directions line research.

Language: Английский

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Medication Overuse Headache: an Updated Review and Clinical Recommendations on Management

Current Neurology and Neuroscience Reports, Journal Year: 2023, Volume and Issue: 23(7), P. 389 - 398

Published: June 5, 2023

Language: Английский

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