Functional connectomics in depression: insights into therapies

Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 27(9), P. 814 - 832

Published: June 5, 2023

Language: Английский

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Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment

Psychopharmacology, Journal Year: 2020, Volume and Issue: 238(5), P. 1265 - 1278

Published: Jan. 15, 2020

Abstract Depression is a leading cause of disability worldwide and improving its treatment core research priority for future programmes. A change in the view psychological biological processes, from seeing them as separate to complementing one another, has introduced new perspectives on pathological mechanisms depression mode action. This review presents theoretical model that incorporated this novel approach, cognitive neuropsychological hypothesis antidepressant proposes treatments decrease negative bias processing emotionally salient information early course treatment, which leads clinically significant mood improvement later treatment. The paper discusses role affective biases development response treatments. It also whether can be applied other interventions potential translational value, including choice, prediction drug development.

Language: Английский

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The neurobiology of treatment-resistant depression: A systematic review of neuroimaging studies

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 132, P. 433 - 448

Published: Dec. 8, 2021

Treatment-resistant depression (TRD) is a debilitating condition associated with higher medical costs, increased illness burden, and reduced quality of life compared to non-treatment-resistant major depressive disorder (MDD). The question arises whether TRD can be considered distinct MDD sub-type based on neurobiological features. To answer this we conducted systematic review neuroimaging studies investigating the differences between non-TRD. Our main findings are that patients show 1) functional connectivity (FC) within default mode network (DMN), 2) FC components DMN other brain areas, 3) hyperactivity regions. In addition, aberrant activity in occipital lobe may play role TRD. limitations most were related inherent confounding factors for comparing non-TRD, such as disease chronicity/severity medication history. Future use prospective longitudinal designs delineate which effects present treatment-naive result progression.

Language: Английский

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Amygdala biomarkers of treatment response in major depressive disorder: An fMRI systematic review of SSRI antidepressants

Psychiatry Research Neuroimaging, Journal Year: 2024, Volume and Issue: 338, P. 111777 - 111777

Published: Jan. 3, 2024

Language: Английский

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Connectome-based models can predict early symptom improvement in major depressive disorder

Journal of Affective Disorders, Journal Year: 2020, Volume and Issue: 273, P. 442 - 452

Published: May 11, 2020

Language: Английский

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Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Human Brain Mapping, Journal Year: 2021, Volume and Issue: 43(1), P. 500 - 542

Published: May 5, 2021

Abstract Sex is a biological variable that contributes to individual variability in brain structure and behavior. Neuroimaging studies of population‐based samples have identified normative differences between males females, many which are exacerbated psychiatric neurological conditions. Still, sex MRI outcomes understudied, particularly clinical with known disease risk, prevalence, expression symptoms. Here we review the existing literature on adult 14 distinct disorders. We discuss commonalities sources variance study designs, analysis procedures, subtype effects, impact these factors interpretation. Lastly, identify key problems neuroimaging offer potential recommendations address current barriers optimize rigor reproducibility. In particular, emphasize importance large‐scale initiatives such as Enhancing NeuroImaging Genetics through Meta‐Analyses consortium, UK Biobank, Human Connectome Project, others provide unprecedented power evaluate sex‐specific phenotypes major diseases.

Language: Английский

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Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression: Recent Critical Advances in Patient Care

Current Treatment Options in Psychiatry, Journal Year: 2021, Volume and Issue: 8(2), P. 47 - 63

Published: March 11, 2021

Abstract Purpose Transcranial magnetic stimulation (TMS) is an evidence-based treatment for pharmacoresistant major depressive disorder (MDD). In the last decade, field has seen significant advances in understanding and use of this new technology. This review aims to describe large, randomized controlled studies leading modern rTMS MDD. It also includes a special section briefly discussing these technologies during COVID-19 pandemic. Recent findings Several approaches are emerging field, including novel reduce time potentially yield optimize maximize clinical outcomes. Of these, theta burst TMS now evidence indicating it non-inferior standard provides advantages administration. indicate that neuroimaging related may be able improve targeting methods identify those patients most likely respond stimulation. Summary While data promising, research remains done individualize procedures. Emerging approaches, such as accelerated advanced methods, require additional replication demonstration real-world utility. Cautious administration pandemic possible with careful attention safety

Language: Английский

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Individualized fMRI connectivity defines signatures of antidepressant and placebo responses in major depression

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(6), P. 2490 - 2499

Published: Feb. 2, 2023

Language: Английский

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Predicting disability progression and cognitive worsening in multiple sclerosis using patterns of grey matter volumes

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2021, Volume and Issue: 92(9), P. 995 - 1006

Published: April 20, 2021

Objective In multiple sclerosis (MS), MRI measures at the whole brain or regional level are only modestly associated with disability, while network-based emerging as promising prognostic markers. We sought to demonstrate whether data-driven patterns of covarying grey matter (GM) volumes predict future disability in secondary progressive MS (SPMS). Methods used cross-sectional structural MRI, and baseline longitudinal data Expanded Disability Status Scale, Nine-Hole Peg Test (9HPT) Symbol Digit Modalities (SDMT), from a clinical trial 988 people SPMS. processed T1-weighted scans obtain GM probability maps applied spatial independent component analysis (ICA). repeated ICA on 400 healthy controls. survival models determine volume cognitive motor worsening. Results identified 15 regionally features. Compared GM, deep lesion volumes, some components correlated more closely outcomes. A mainly basal ganglia had highest correlations SDMT was worsening (HR=1.29, 95% CI 1.09 1.52, p<0.005). Two were 9HPT (HR=1.30, 1.06 1.60, p<0.01 HR=1.21, 1.01 1.45, p<0.05). could better (C-index=0.69–0.71) compared including (C-index=0.65–0.69, p value for all comparison <0.05). Conclusions The progression predicted by regions patterns, than single whole-brain measures. ICA, which may represent networks, can be trials play role stratifying participants who have most potential show treatment effect.

Language: Английский

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Transcranial focused ultrasound stimulation of cortical and thalamic somatosensory areas in human

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(7), P. e0288654 - e0288654

Published: July 21, 2023

The effects of transcranial focused ultrasound (FUS) stimulation the primary somatosensory cortex and its thalamic projection ( i . e ., ventral posterolateral nucleus) on generation electroencephalographic (EEG) responses were evaluated in healthy human volunteers. Stimulation unilateral circuits corresponding to non-dominant hand generated EEG evoked potentials across all participants; however, not perceived stimulation-mediated tactile sensations hand. These FUS-evoked (FEP) observed from both brain hemispheres shared similarities with (SSEP) median nerve stimulation. Use a 0.5 ms pulse duration (PD) sonication given at 70% duty cycle, compared use 1 2 PD, elicited more distinctive FEP peak features hemisphere ipsilateral sonication. Although several participants reported hearing tones associated FUS stimulation, likely be confounded by auditory sensation based separate measurement (AEP) tonal (mimicking same repetition frequency as stimulation). Off-line changes resting-state functional connectivity (FC) revealed that enhanced network sensorimotor sensory integration areas, which lasted for least than an hour. Clinical neurological evaluations, EEG, neuroanatomical MRI did reveal any adverse or unintended sonication, attesting safety. results suggest may induce long-term neuroplasticity humans, indicating neurotherapeutic potential various neuropsychiatric conditions.

Language: Английский

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