Intestinal homeostasis in the gut-lung-kidney axis: a prospective therapeutic target in immune-related chronic kidney diseases DOI Creative Commons

Xinyin Liu,

Xiaoran Wang, Peipei Zhang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 1, 2023

In recent years, the role of intestinal homeostasis in health has received increasing interest, significantly improving our understanding complex pathophysiological interactions gut with other organs. Microbiota dysbiosis, impaired barrier, and aberrant immunity appear to contribute pathogenesis immune-related chronic kidney diseases (CKD). Meanwhile, relationship between pathological changes respiratory tract (e.g., infection, fibrosis, granuloma) CKD cannot be ignored. The present review aimed elucidate new underlying mechanism CKD. lungs may affect function through mediation. Communication is believed exist lung microbiota across long physiological distances. Following inhalation various pathogenic factors particulate matter 2.5 mum or less diameter, pathogen) air mouth nose, considering anatomical connection nasopharynx lungs, microbiome regulates oxidative stress inflammatory states kidneys. intestine participates differentiation T cells promotes migration immune specific This better explain occurrence progression caused by upper precursor infection suggests complications some autoimmune anti-neutrophil cytoplasm antibodies -associated vasculitis, systemic lupus erythematosus). can also acute distress syndrome obstructive pulmonary disease). We conclude that damage barrier appears development gut-lung-kidney interplay, leading us establish axis hypothesis. Further, we discuss possible therapeutic interventions targets. For example, using prebiotics, probiotics, laxatives Rhubarb officinale) regulate ecology alleviate stress, as well improve local system communication

Language: Английский

Immunotherapy Strategy for Systemic Autoimmune Diseases: Betting on CAR-T Cells and Antibodies DOI Creative Commons
Vitaly Chasov,

Ekaterina Zmievskaya,

Irina Ganeeva

et al.

Antibodies, Journal Year: 2024, Volume and Issue: 13(1), P. 10 - 10

Published: Feb. 1, 2024

Systemic autoimmune diseases (SAIDs), such as systemic lupus erythematosus (SLE), sclerosis (SSc) and rheumatoid arthritis (RA), are fully related to the unregulated innate adaptive immune systems involved in their pathogenesis. They have similar pathogenic characteristics, including interferon signature, loss of tolerance self-nuclear antigens, enhanced tissue damage like necrosis fibrosis. Glucocorticoids immunosuppressants, which limited specificity prone tolerance, used first-line therapy. A plethora novel immunotherapies been developed, monoclonal bispecific antibodies, other biological agents target cellular soluble factors disease pathogenesis, B cells, co-stimulatory molecules, cytokines or receptors, signaling molecules. Many these shown encouraging results clinical trials. CAR-T cell therapy is considered most promising technique for curing diseases, with recent successes treatment SLE SSc. Here, we overview therapeutic approaches based on cells antibodies targeting diseases.

Language: Английский

Citations

18
The Complex Role of Gut Microbiota in Systemic Lupus Erythematosus and Lupus Nephritis: From Pathogenetic Factor to Therapeutic Target DOI Creative Commons
E Parodi,

M. Novi,

Paolo Bottino

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 445 - 445

Published: Feb. 18, 2025

The role of gut microbiota (GM) and intestinal dysbiosis in triggering the onset and/or modulating severity progression lupus nephritis (LN) has been object intense research over last few years. Some alterations at phyla level, such as abundance Proteobacteria reduction Firmicutes/Bacteroidetes (F/B) ratio α-diversity have consistently reported systemic erythematosus (SLE), whereas a more specific ascribed to some species (Bacteroides thetaiotaomicron Ruminococcus gnavus) LN. Underlying mechanisms include microbial translocation through "leaky gut" subsequent molecular mimicry, immune dysregulation (alteration IFNγ levels balance between Treg Th17 subsets), epigenetic interactions. Levels bacterial metabolites, butyrate other short-chain fatty acids (SCFAs), appear play key Beyond components GM, virome mycobiome are also increasingly recognized important players modulation an response. On hand, microbiota-based therapy appears promising includes diet, prebiotics, probiotics, symbiotics, fecal transplantation (FMT). could correct critical alterations, F/B Treg/Th17 imbalance, blunt production autoantibodies renal damage. Despite current limits, GM is emerging powerful environmental factor that be harnessed interfere with leading SLE, preventing flares organ damage, including aim this review provide state-of-the-art analysis SLE LN on one while exploring possible therapeutic manipulation control disease hand.

Language: Английский

Citations

1
Environmental factors and rheumatic diseases DOI
Stefano Rodolfi, Carlo Selmi

Best Practice & Research Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown, P. 102053 - 102053

Published: March 1, 2025

Language: Английский

Citations

0
Exploring Gut Microbiota in Systemic Lupus Erythematosus: Insights and Biomarker Discovery Potential DOI

Lingyue Jin,

Jie Xiao, Yuhong Luo

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: April 11, 2025

Language: Английский

Citations

0
Systemic lupus erythematosus therapeutic strategy: From immunotherapy to gut microbiota modulation DOI Open Access
Vitaly Chasov,

Ekaterina Zmievskaya,

Irina Ganeeva

et al.

Journal of Biomedical Research, Journal Year: 2024, Volume and Issue: 38(6), P. 531 - 531

Published: Jan. 1, 2024

Systemic lupus erythematosus (SLE) is characterized by a systemic dysfunction of the innate and adaptive immune systems, leading to an attack on healthy tissues body. During development SLE, pathogenic features, such as formation autoantibodies self-nuclear antigens, caused tissue damage including necrosis fibrosis, with increased expression type Ⅰ interferon (IFN) regulated genes. Treatment immunosuppressants glucocorticoids, which are used standard therapy, not effective enough causes side effects. As alternative, more immunotherapies have been developed, monoclonal bispecific antibodies that target B cells, T co-stimulatory molecules, cytokines or their receptors, signaling molecules. Encouraging results observed in clinical trials some these therapies. Furthermore, chimeric antigen receptor cells (CAR-T) therapy has emerged most effective, safe, promising treatment option for demonstrated successful pilot studies. Additionally, emerging evidence suggests gut microbiota dysbiosis may play significant role severity use methods normalize microbiota, particularly fecal transplantation (FMT), opens up new opportunities SLE.

Language: Английский

Citations

3
Disruption in the human microbiome causing behavioural changes in bipolar disorder DOI
Sandhya Srinivasan

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Intestinal homeostasis in the gut-lung-kidney axis: a prospective therapeutic target in immune-related chronic kidney diseases DOI Creative Commons

Xinyin Liu,

Xiaoran Wang, Peipei Zhang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 1, 2023

In recent years, the role of intestinal homeostasis in health has received increasing interest, significantly improving our understanding complex pathophysiological interactions gut with other organs. Microbiota dysbiosis, impaired barrier, and aberrant immunity appear to contribute pathogenesis immune-related chronic kidney diseases (CKD). Meanwhile, relationship between pathological changes respiratory tract (e.g., infection, fibrosis, granuloma) CKD cannot be ignored. The present review aimed elucidate new underlying mechanism CKD. lungs may affect function through mediation. Communication is believed exist lung microbiota across long physiological distances. Following inhalation various pathogenic factors particulate matter 2.5 mum or less diameter, pathogen) air mouth nose, considering anatomical connection nasopharynx lungs, microbiome regulates oxidative stress inflammatory states kidneys. intestine participates differentiation T cells promotes migration immune specific This better explain occurrence progression caused by upper precursor infection suggests complications some autoimmune anti-neutrophil cytoplasm antibodies -associated vasculitis, systemic lupus erythematosus). can also acute distress syndrome obstructive pulmonary disease). We conclude that damage barrier appears development gut-lung-kidney interplay, leading us establish axis hypothesis. Further, we discuss possible therapeutic interventions targets. For example, using prebiotics, probiotics, laxatives Rhubarb officinale) regulate ecology alleviate stress, as well improve local system communication

Language: Английский

Citations

5