Mechanisms of Azole Potentiation: Insights from Drug Repurposing Approaches

ACS Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

The emergence of azole resistance and tolerance in pathogenic fungi has emerged as a significant public health concern, emphasizing the urgency for innovative strategies to bolster efficacy azole-based treatments. Drug repurposing stands promising practical avenue advancing antifungal therapy, with potential swift clinical translation. This review offers comprehensive overview synergistic agents uncovered through drug strategies, alongside an in-depth exploration mechanisms by which these augment potency. Drawing from mechanisms, we delineate aimed at enhancing effectiveness, such inhibiting efflux pumps elevate concentrations within fungal cells, intensifying ergosterol synthesis inhibition, mitigating cell azoles, disrupting biological processes extending beyond synthesis. is beneficial development potentiators, it meticulously examines instances provides nuanced discussions on underlying progression potentiators strategies.

Language: Английский

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Recent Advances of Halloysite Nanotubes in Biomedical Applications

Small, Journal Year: 2023, Volume and Issue: 20(2)

Published: Sept. 5, 2023

Abstract Halloysite nanotubes (HNTs) have emerged as a highly regarded choice in biomedical research due to their exceptional attributes, including superior loading capacity, customizable surface characteristics, and excellent biocompatibility. HNTs feature tubular structures comprising alumina silica layers, endowing them with large area versatile chemistries that facilitate selective modifications. Moreover, substantial pore volume wide range of sizes enable efficient entrapment diverse functional molecules. This comprehensive review highlights the broad application spectrum HNTs, shedding light on potential innovative effective therapeutic agents across various diseases. It emphasizes necessity optimizing drug delivery techniques, developing targeted systems, rigorously evaluating biocompatibility safety through preclinical clinical investigations, exploring combination therapies, advancing scientific understanding. With further advancements, hold promise revolutionize pharmaceutical industry, opening new avenues for development transformative treatments.

Language: Английский

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Prevalence of pharmaceuticals and personal care products, microplastics and co-infecting microbes in the post-COVID-19 era and its implications on antimicrobial resistance and potential endocrine disruptive effects

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 904, P. 166419 - 166419

Published: Aug. 23, 2023

Language: Английский

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Moesziomyces aphidis Bloodstream Infection in Oncologic Patient: First Report in Poland

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(2), P. 95 - 95

Published: Jan. 24, 2025

Moesziomyces spp. (Pseudozyma) is a genus recognized as new opportunistic human pathogen, causing systemic infections including premature neonates and adult patients. These fungi’s natural resistance to caspofungin enables them spread through vascular catheter colonization, making etiological agent associated with fungal bloodstream (FBIs) significant contributor high mortality rates. In this report, we present case of fungemia caused by aphidis species in patient medical history that revealed pancreatic cancer infiltrating the duodenum bile ducts. During hospitalization, M. was cultured twice from peripheral blood samples on Sabouraud agar. The strain sensitive amphotericin B voriconazole. vitro susceptibility testing fluconazole, caspofungin, anidulafungin, micafungin. Antifungal therapy voriconazole resulted resolution clinical symptoms infection. Related fungemia, reviewed total three cases Europe published PubMed database between 2003 2024. To best our knowledge, first FBI Poland fourth an Europe.

Language: Английский

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From Co-Infections to Autoimmune Disease via Hyperactivated Innate Immunity: COVID-19 Autoimmune Coagulopathies, Autoimmune Myocarditis and Multisystem Inflammatory Syndrome in Children

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 3001 - 3001

Published: Feb. 3, 2023

Neutrophilia and the production of neutrophil extracellular traps (NETs) are two many measures increased inflammation in severe COVID-19 that also accompany its autoimmune complications, including coagulopathies, myocarditis multisystem inflammatory syndrome children (MIS-C). This paper integrates currently disparate innate hyperactivation relates these to SARS-CoV-2 activation immunity. Aggregated data include Toll-like receptors (TLRs), nucleotide-binding oligomerization domain (NOD) receptors, NOD leucine-rich repeat pyrin-domain-containing (NLRPs), retinoic acid-inducible gene I (RIG-I) melanoma-differentiation-associated 5 (MDA-5). mainly activates virus-associated TLR3, TLR7, TLR8, NLRP3, RIG-1 MDA-5. Severe COVID-19, however, is characterized by additional TLR1, TLR2, TLR4, TLR5, TLR6, NOD1 NOD2, which primarily responsive bacterial antigens. The patterns Kawasaki disease, or MIS-C, mimic those rather than alone suggesting autoimmunity follows combined SARS-CoV-2-bacterial infections. Viral known synergize produce required support disease pathology. Additional studies demonstrate anti-bacterial antibodies account for autoantigen targets complications.

Language: Английский

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Enhanced antifungal activity of posaconazole against Candida auris by HIV protease inhibitors, atazanavir and saquinavir

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 18, 2024

Abstract The increasing incidence and dissemination of multidrug-resistant Candida auris represents a serious global threat. emergence pan-resistant C. exhibiting resistance to all three classes antifungals magnifies the need for novel therapeutic interventions. We identified that two HIV protease inhibitors, atazanavir saquinavir, in combination with posaconazole exhibited potent activity against vitro vivo . Both saquinavir remarkable synergistic tested isolates other medically important species. In time-kill assay, both drugs restored fungistatic posaconazole, resulting reduction 5 5.6 log 10 , respectively. Furthermore, contrast individual drugs, combinations effectively inhibited biofilm formation by 66.2 81.2%, Finally, efficacy were mouse model infection. atazanavir/posaconazole saquinavir/posaconazole significantly reduced burden mice kidneys 2.04- (99.1%) 1.44-log (96.4%) colony forming unit, Altogether, these results suggest inhibitors warrants further investigation as new regimen treatment infections.

Language: Английский

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Hazards Associated with the Combined Application of Fungicides and Poultry Litter in Agricultural Areas

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(1), P. 110 - 134

Published: Jan. 9, 2024

In recent decades, the poultry farming industry has assumed a pivotal role in meeting global demand for affordable animal proteins. While makes substantial contribution to food security and nutrition, it also presents environmental public health challenges. The use of litter as fertilizer agricultural soils raises concerns about transfer pathogens drug-resistant microorganisms from farms crop production areas. On other hand, according Food Agriculture Organization United Nations (FAO), fungicides represent second most used chemical group practices. this context, receive application both production. This practice can result fungal contamination soil development antifungal resistance. article explores necessity monitoring resistance, particularly areas with co-application fungicides. It highlights fungi ecosystems, decomposition, mutualistic plant associations. We call interdisciplinary research comprehensively understand resistance environment. approach seeks promote sustainability realms human health, agriculture, environment, aligning seamlessly One Health concept.

Language: Английский

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Role of the microbiota-gut-brain axis in postacute COVID syndrome

AJP Gastrointestinal and Liver Physiology, Journal Year: 2023, Volume and Issue: 324(4), P. G322 - G328

Published: March 7, 2023

The COVID-19 pandemic has resulted in the infection of hundreds millions individuals over past 3 years, coupled with deaths. Along these more acute impacts infection, a large subset patients developed symptoms that collectively comprise "postacute sequelae COVID-19" (PASC, also known as long COVID), which can persist for months and maybe even years. In this review, we outline current knowledge on role impaired microbiota-gut-brain (MGB) axis signaling development PASC potential mechanisms involved, may lead to better understanding disease progression treatment options future.

Language: Английский

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Is the Rising Fungal Resistance a Global Concern?

Archives of Clinical Infectious Diseases, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 28, 2025

Language: Английский

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Nanotherapeutics for the Delivery of Antifungal Drugs

Therapeutic Delivery, Journal Year: 2024, Volume and Issue: 15(1), P. 55 - 76

Published: Jan. 1, 2024

The treatment of fungal infections is challenging with high death rates reported among immunocompromised patients. currently available antifungals suffer from poor bioavailability and solubility, pharmacokinetics, drug resistance, limited cellular uptake. clinical pipeline new dry. incorporation antifungal drugs into polymer-based nanocarriers to form nanotherapeutics a promising approach enhance the therapeutic outcomes drugs. This review summarizes different strategies that have been explored for delivery antifungals, resulting in enhanced outcomes, such as improved targeted/sustained delivery, prolonged circulation, retention at localized site action, overcoming resistance when compared free

Language: Английский

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