Enantioselective effect of chiral prothioconazole on the conformation of bovine serum albumin

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 240, P. 124541 - 124541

Published: April 20, 2023

Language: Английский

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Designing an anticancer Pd(II) complex as poly(ADP-ribose) polymerase 1 inhibitor

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139885 - 139885

Published: Jan. 14, 2025

Language: Английский

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Computational and experimental examinations of new antitumor palladium(II) complex: CT-DNA-/BSA-binding, in-silico prediction, DFT perspective, docking, molecular dynamics simulation and ONIOM

Journal of Biomolecular Structure and Dynamics, Journal Year: 2023, Volume and Issue: 42(10), P. 5447 - 5469

Published: June 22, 2023

Since the design of metal complexes with better biological activities is important, herein a new palladium(II) complex bearing en and acac (en stand for ethylenediamine acetylacetonato, respectively) as its ligands, [Pd(en)(acac)]NO

Language: Английский

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A new zinc(II) complex of 2-benzoimidazoledisulfide ligand: synthesis, X-ray crystallographic structure, investigation of CT-DNA and BSA interaction by spectroscopic techniques and molecular docking

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2023, Volume and Issue: 443, P. 114830 - 114830

Published: May 11, 2023

Language: Английский

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Exploring the cytotoxicity on human lung cancer cells and DNA binding stratagem of camptothecin functionalised silver nanoparticles through multi-spectroscopic, and calorimetric approach

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 3, 2023

Abstract The influence of nanoparticles inside the human body and their interactions with biological macromolecules need to be explored/studied prior specific applications. objective this study is find potential camptothecin functionalised silver (CMT-AgNPs) in biomedical This article primarily investigates binding stratagem CMT-AgNPs calf thymus DNA (ctDNA) through a series spectroscopic calorimetric methods then analyses anticancer activity cytotoxicity CMT-AgNPs. were synthesized using simple one pot method characterized UV–Visible, fourier transform infrared (FTIR) spectroscopy, X-ray diffraction high-resolution transmission electron microscopy (HRTEM). average size 10 ± 2 nm. A group experimental techniques such as UV–Visible spectrophotometry, fluorescence dye displacement assay, circular dichroism (CD) viscosity analysis unravelled typical groove mode ctDNA. CD measurement evidenced minor conformational alterations double helical structure ctDNA presence information deduced from isothermal titration calorimetry (ITC) experiment that was exothermic spontaneous nature. Moreover, all thermodynamic parameters extracted ITC data. constants obtained UV absorption experiments, studies consistently order 4 Mol −1 . All these results validated formation CMT-AgNPs–ctDNA complex unambiguously confirm An exhaustive vitro MTT assay by CMT against A549, HT29, HeLa L929 cell lines revealed capability agent.

Language: Английский

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Synthesis and characterization of mixed-ligand Co(II) complexes with gabapentin or pregabalin and diimine coligands: DNA interaction, antibacterial, antifungal and molecular docking studies

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1304, P. 137609 - 137609

Published: Jan. 24, 2024

Language: Английский

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Modern approaches to studying interactions of metal complexes with DNA

Russian Chemical Bulletin, Journal Year: 2025, Volume and Issue: 74(3), P. 559 - 584

Published: March 1, 2025

Language: Английский

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Structure-bioactivity relationship study on anticancer Pd and Pt complexes with aliphatic glycine derivative ligands

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 317, P. 124408 - 124408

Published: May 6, 2024

Language: Английский

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Thermodynamic and functional changes of alpha-chymotrypsin after interaction with gallic acid

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 313, P. 124109 - 124109

Published: March 3, 2024

Language: Английский

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Aminoquinoline-based Re(I) tricarbonyl complexes: Insights into their antiproliferative activity and mechanisms of action

European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 266, P. 116094 - 116094

Published: Dec. 27, 2023

In an effort to develop new potent anticancer agents, two Schiff base rhenium(I) tricarbonyl complexes, containing the ubiquitous aminoquinoline scaffold, were synthesized. The structural integrity of iminopyridyl-substituted ligands and corresponding fac-rhenium(I) complexes confirmed by X-ray crystallography, spectroscopic analytical techniques. Both showed adequate stability over a 48-h incubation period. Furthermore, cytotoxic activity precursor evaluated against hormone-dependent MCF-7 hormone-independent triple negative MDA-MB-231 breast cancer cell lines. Inclusion [Re(CO)3Cl]+ entity significantly enhanced cytotoxicity tested Remarkably, incorporation Schiff-base iminoquinolyl notably Re(I) in comparison with iminopyridyl entity. Notably, quinolyl-substituted complex up three-fold higher than cisplatin lines, underpinning significance quinoline pharmacophore rational drug design. addition, most active better selectivity towards cells non-tumorigenic FG-0 cells. Western blotting revealed that increased levels γH2AX, key DNA damage response protein. Moreover, apoptosis was both lines due detection cleaved PARP. show favourable binding affinities calf thymus (CT-DNA), bovine serum albumin (BSA), order their interactions align effects. silico molecular simulations also performed CT-DNA, BSA targets.

Language: Английский

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