Selenium Metabolism and Biosynthesis of Selenoproteins in the Human Body

Biochemistry (Moscow), Journal Year: 2022, Volume and Issue: 87(S1), P. S168 - S177

Published: Jan. 1, 2022

Language: Английский

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Scientific opinion on the tolerable upper intake level for selenium

EFSA Journal, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 1, 2023

Following a request from the European Commission, EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver scientific opinion tolerable upper intake level (UL) for selenium. Systematic reviews of literature were conducted identify evidence regarding excess selenium clinical effects potential biomarkers effect, risk chronic diseases impaired neuropsychological development in humans. Alopecia, as an early observable feature well-established adverse effect exposure, is selected critical endpoint which base UL A lowest-observed-adverse-effect-level (LOAEL) 330 μg/day identified large randomised controlled trial humans (the Selenium Vitamin E Cancer Prevention Trial (SELECT)), uncertainty factor 1.3 applied. 255 established adult men women (including pregnant lactating women). ULs children are derived adults using allometric scaling (body weight0.75). Based available data, consumers unlikely exceed UL, except regular users food supplements containing high daily doses or Brazil nuts. No has been reported with current levels countries (excluding supplements) toddlers children, arising natural content foods does not raise reasons concern. Selenium-containing should be used caution, based individual needs.

Language: Английский

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Ferroptosis: mechanisms and implications for cancer development and therapy response

Trends in Cell Biology, Journal Year: 2023, Volume and Issue: 33(12), P. 1062 - 1076

Published: May 23, 2023

Language: Английский

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The Regulation of Selenoproteins in Diabetes: A New Way to Treat Diabetes

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(20), P. 1541 - 1547

Published: May 6, 2024

Selenium is an essential micronutrient required for the synthesis and function of selenoproteins, most which are enzymes involved in maintaining oxidative balance body. Diabetes a group metabolic disorders characterized by high blood glucose levels over prolonged period time. There three main types diabetes: type 1, 2, gestational diabetes. This review summarizes recent advances field diabetes research with emphasis on roles selenoproteins disturbance We also discuss interaction between lipid metabolism to provide new insights into prevention treatment

Language: Английский

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Selenium in cancer management: exploring the therapeutic potential

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 7, 2025

Selenium (Se) is important and plays significant roles in many biological processes or physiological activities. Prolonged selenium deficiency has been conclusively linked to an elevated risk of various diseases, including but not limited cancer, cardiovascular disease, inflammatory bowel Keshan acquired immunodeficiency syndrome. The intricate relationship between status health outcomes believed be characterized by a non-linear U-shaped dose-response curve. This review delves into the significance maintaining optimal levels detrimental effects that can arise from deficiency. Of particular interest role both prevention treatment cancer. Finally, this also explores diverse classes entities, encompassing selenoproteins, compounds nanoparticles, while examining mechanisms molecular targets their anticancer efficacy.

Language: Английский

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Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity

Biomolecules, Journal Year: 2020, Volume and Issue: 10(4), P. 658 - 658

Published: April 24, 2020

Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its possible roles in obesity development adipocyte metabolism are unclear. The objective of the present study review current data on Se status discuss interference between selenoprotein physiology pathogenesis. overview meta-analysis studies blood P (SELENOP) levels, as well glutathione peroxidase (GPX) activity obese subjects, have yielded heterogenous even conflicting results. Laboratory demonstrate that may modulate preadipocyte proliferation adipogenic differentiation, also interfere with insulin signaling, regulate lipolysis. Knockout models demonstrated machinery, including endoplasmic reticulum-resident selenoproteins together GPXs thioredoxin reductases (TXNRDs), functioning. In conclusion, appear play an essential role adipose tissue physiology, although human inconsistent. Taken together, these findings do not support utility supplementation prevent or alleviate humans. Further laboratory required elucidate associations obesity.

Language: Английский

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Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study

Redox Biology, Journal Year: 2021, Volume and Issue: 47, P. 102145 - 102145

Published: Sept. 21, 2021

The trace element selenium is of essential importance for the synthesis a set redox active proteins. We investigated three complementary serum status biomarkers in relation to overall survival and recurrence following diagnosis primary invasive breast cancer large prospective cohort study. Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) population-based study including multiple participating hospitals. Main analyses included 1996 patients with new cancer, blood sampling at time diagnosis. In sera patients, total selenium, selenoprotein P (SELENOP), glutathione peroxidase 3 (GPx3) activity was analysed. All showed positive correlation (p < 0.001), supporting high quality samples analytical techniques. During 13,306 person years follow-up, 310 deaths 167 recurrent events occurred. fully adjusted Cox models, all correlated inversely mortality trend <0.001) compared lowest quintile, hazard ratios (95% confidence interval) highest quintile SELENOP GPx3 were 0.42 (0.28–0.63), 0.51 (0.36–0.73) 0.52 (0.36–0.75), respectively. Low associated more recurrences (Q5 vs Q1: HR (95%CI); 0.57 (0.35–0.92), = 0.005). Patients low according (triple deficient) had risk an probability ∼50% after 8 years, particular as those having least one marker quintile; 0.30 (0.21–0.43). Prediction based on outperformed established tumour characteristics like histologic grade, number involved lymph nodes or size. An assessment Se identifies exceptionally poor prognosis.

Language: Английский

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Trace Element Selenium Effectively Alleviates Intestinal Diseases

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(21), P. 11708 - 11708

Published: Oct. 28, 2021

Selenium (Se) is an essential trace element in the body. It mainly used body form of selenoproteins and has a variety biological functions. Intestinal diseases caused by chronic inflammation are among most important threats to human health, there no complete cure at present. Due its excellent antioxidant function, Se been proven be effective alleviating intestinal such as inflammatory bowel (IBDs). Therefore, this paper introduces role tract mechanism their involvement mediation diseases. In addition, it advantages disadvantages nano-Se new preparation traditional supplement prevention treatment diseases, so provide reference for further exploration interaction between selenium health.

Language: Английский

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Selenium as an important factor in various disease states - a review.

PubMed, Journal Year: 2022, Volume and Issue: 21, P. 948 - 966

Published: Jan. 1, 2022

Selenium (Se) is an element that has a pro-health effect on humans and animals. However, both the deficiency of this its excess may prove harmful to body depending chemical form selenium, duration supplementation, human health condition. Many data indicate insufficient coverage demand for selenium in animals due low content soils food products. A balance physiological process can be achieved via proper percentage organically active minerals feed as well beings. trace mineral great importance body, required maintenance variety processes; primarily, maintains immune endocrine, metabolic, cellular homeostasis. Recently, been emerging most promising treatment option various disorders. Therefore, research based Se increasing recent times. The present review designed provide up-to-date information related different forms effects health.

Language: Английский

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Selenoprotein P – Selenium transport protein, enzyme and biomarker of selenium status

Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 191, P. 150 - 163

Published: Sept. 5, 2022

Language: Английский

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