The importance of selenium in food enrichment processes. A comprehensive review

Journal of Trace Elements in Medicine and Biology, Journal Year: 2023, Volume and Issue: 79, P. 127260 - 127260

Published: July 5, 2023

Selenium is an essential element that determines the proper life functions of human and animal organisms. The content selenium in food varies depending on region soil conditions. Therefore, main source a properly selected diet. However, many countries, there are shortages this local food. Too low amount can lead to adverse changes body. consequence may also be occurrence numerous potentially life-threatening diseases. it very important introduce methods condition supplementation appropriate chemical form element, especially areas with deficient content. This review aims summarize published literature characterization different types selenium-enriched foods. At same time, legal regulations prospects for future related production enriched presented. It should noted limitations concerns such due narrow safety range between necessary toxic dose element. has been treated special care long time. For reason, presented mechanisms processes increasing scale constantly monitored. Appropriate monitoring development technological process important. Such ensure consumer repeatability obtained product. Understanding possibilities accumulation by plants animals one most directions modern bromatology science supplementation. particularly case rational nutrition supplementing diet as selenium. Food technology facing these challenges today.

Language: Английский

---

Current understanding and future directions of cruciferous vegetables and their phytochemicals to combat neurological diseases

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(3), P. 1381 - 1399

Published: Jan. 12, 2024

Abstract Neurological disorders incidences are increasing drastically due to complex pathophysiology, and the nonavailability of disease‐modifying agents. Several attempts have been made identify new potential chemicals combat these neurological abnormalities. At present, complete abolishment diseases is not attainable except for symptomatic relief. However, dietary recommendations help brain development or improvement increased over years. In recent times, cruciferous vegetables their phytochemicals identified from preclinical clinical investigations as neuroprotective The present review highlights beneficial effects molecular mechanisms such indole‐3‐carbinol, diindolylmethane, sulforaphane, kaempferol, selenium, lutein, zeaxanthin, vitamins against including Parkinson's disease, Alzheimer's stroke, Huntington's autism spectra disorders, anxiety, depression, pain. Most protect by eliciting antioxidant, anti‐inflammatory, antiapoptotic properties. Regular intake may benefit prevention treatment diseases. suggests that there a lacuna in identifying efficacy phytochemicals. Therefore, high‐quality future studies should firmly establish above‐mentioned settings.

Language: Английский

---

Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 688 - 688

Published: June 3, 2024

Cardiovascular diseases stand as the predominant global cause of mortality, exerting a profound impact on both life expectancy and its quality. Given their immense public health burden, extensive efforts have been dedicated to comprehending underlying mechanisms developing strategies for prevention treatment. Selenium, crucial participant in redox reactions, emerges notable factor maintaining myocardial cell homeostasis influencing progression cardiovascular disorders. Some disorders, such Keshan disease, are directly linked with environmental deficiency. Nevertheless, precise extent system remains unclear, marked by contradictory findings existing literature. High selenium levels associated an increased risk hypertension, while lower concentrations heart failure atrial fibrillation. Although some trials shown potential effectiveness specific groups patients, large cohort supplementation attempts generally yielded unsatisfactory outcomes. Consequently, there persists significant need further research aimed at delineating patient cohorts that would benefit from supplementation.

Language: Английский

---

Selenium Mitigates Caerulein and LPS-induced Severe Acute Pancreatitis by Inhibiting MAPK, NF-κB, and STAT3 Signaling via the Nrf2/HO-1 Pathway

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

---

Probiotic-driven advancement: Exploring the intricacies of mineral absorption in the human body

Food Chemistry X, Journal Year: 2023, Volume and Issue: 21, P. 101067 - 101067

Published: Dec. 13, 2023

The interplay between probiotics and mineral absorption is a topic of growing interest due to its great potential for human well-being. Minerals are vital in various physiological processes, deficiencies can lead significant health problems. Probiotics, beneficial microorganisms residing the gut, have recently gained attention their ability modulate mitigate deficiencies. aim present review investigate intricate connection key minerals such as calcium, selenium, zinc, magnesium, potassium. However, variability probiotic strains, dosages, alongside unique composition individuals gut microbiota, pose challenges establishing universal guidelines. An improved understanding these mechanisms will enable development targeted interventions optimize promote health.

Language: Английский

---

Detoxification of Selenium Yeast on Mycotoxins and Heavy Metals: a Review

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 201(11), P. 5441 - 5454

Published: Jan. 20, 2023

Language: Английский

---

Supplement Use and Increased Risks of Cancer: Unveiling the Other Side of the Coin

Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 880 - 880

Published: Feb. 22, 2024

There is a rising trend in the consumption of dietary supplements, especially among adults, with purpose improving health. While marketing campaigns tout potential health benefits using it critical to evaluate harmful effects associated these supplements as well. The majority scarce research on vitamins focuses acute or chronic toxicities use supplements. Quality still required further investigate risks long-term risk developing cancers. present review concentrates studies that have investigated association between cancers and mortality Such an has been reported for several vitamins, minerals, other Even though come their own shortcomings critics, they must draw attention adverse advise consumers healthcare providers ponder extensive

Language: Английский

---

Effect of Pleurotus eryngii mycelial fermentation on the composition and antioxidant properties of tartary buckwheat

Heliyon, Journal Year: 2024, Volume and Issue: 10(4), P. e25980 - e25980

Published: Feb. 1, 2024

In this study, we investigated the effect of solid-state fermentation

Language: Английский

---

Exploring the Link between Oxidative Stress, Selenium Levels, and Obesity in Youth

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7276 - 7276

Published: July 2, 2024

Obesity is a worldwide increasing concern. Although in adults this easily estimated with the body mass index, children, who are constantly growing and whose bodies changing, reference points to assess weight status age gender, need corroboration complementary data, making their quantification highly difficult. The present review explores interaction spectrum of oxidative stress, selenium status, obesity children adolescents. Any factor related stress that triggers and, conversely, induces part vicious circle, complex chain mechanisms derive from each other reinforce serious health consequences. Selenium its compounds exhibit key antioxidant activity also have significant role nutritional evaluation obese children. balance intake, retention, metabolism emerges as vital aspect health, reflecting interactions between diet, obesity. Understanding whether contributor or consequence could inform interventions public strategies aimed at preventing managing an early age.

Language: Английский

---

Epilepsy: Mitochondrial connections to the ‘Sacred’ disease

Mitochondrion, Journal Year: 2023, Volume and Issue: 72, P. 84 - 101

Published: Aug. 13, 2023

Over 65 million people suffer from recurrent, unprovoked seizures. The lack of validated biomarkers specific for myriad forms epilepsy makes diagnosis challenging. Diagnosis and monitoring childhood add to the need non-invasive biomarkers, especially when evaluating antiseizure medications. Although underlying mechanisms epileptogenesis are not fully understood, evidence mitochondrial involvement is substantial. Seizures affect 35%-60% patients diagnosed with diseases. Mitochondrial dysfunction pathophysiological in various epilepsies, including those non-mitochondrial origin. Decreased ATP production caused by malfunctioning brain cell mitochondria leads altered neuronal bioenergetics, metabolism neurological complications, Iron-dependent lipid peroxidation initiates ferroptosis, a death pathway that aligns morphology found neurodegenerative diseases (NDDs). Studies mouse genetic models seizure phenotypes where function an essential selenoprotein (GPX4) targeted suggest roles ferroptosis epilepsy. GPX4 pivotal NDDs, selenium protects interneurons ferroptosis. Selenium central nervous system micronutrient trace element. Low serum concentrations other elements minerals, iron, noted diagnosing supplements alleviate intractable seizures children reduced GPX activity. Copper cuproptosis, like iron link NDDs. Connecting these mechanistic pathways selenoproteins provides new insights into treating seizures, pointing using medicines prodrugs lipoic acid treat potential alternative therapeutic approaches transcranial magnetic stimulation (transcranial), photobiomodulation vagus nerve stimulation.

Language: Английский

---