Metal-induced oxidative stress and human plasma protein oxidation after SARS-CoV-2 infection DOI Creative Commons
Baikuntha Aryal,

Joseph Tillotson,

Kiwon Ok

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 10, 2023

Pathogenesis of COVID-19 by SARS-CoV-2 resulted in a global pandemic and public health emergency 2020. Viral infection can induce oxidative stress through reactive oxygen species (ROS). Inflammation environmental are major sources after infection. Micronutrients such as iron, copper, zinc, manganese play various roles human tissues their imbalance blood impact immune responses against pathogens including SARS CoV-2. We hypothesized that alteration free metal ions during metal-catalyzed oxidation plays critical role towards pathogenesis analyzed convalescent hospitalized patient plasma using orthogonal analytical techniques to determine redox active concentrations, overall protein oxidation, modifications, levels via proteomics understand the consequences metal-induced proteins. Metal analysis ICP-MS showed significantly greater concentrations copper compared healthy controls. demonstrate total carbonylation, other deamidation proteins Proteomics hemoglobulin were elevated plasma. Molecular modeling concurred with potential interactions between iron binding CoV-2 surface Overall, increased metals indicate stress-induced may be consequence host cell resulting altered cellular homeostasis.

Language: Английский

Serum Zinc, Copper, and Other Biometals Are Associated with COVID-19 Severity Markers DOI Creative Commons
Anatoly V. Skalny, Peter Timashev, Michael Aschner

et al.

Metabolites, Journal Year: 2021, Volume and Issue: 11(4), P. 244 - 244

Published: April 15, 2021

The objective of the present study was to evaluate serum metal levels in COVID-19 patients with different disease severity, and investigate independent association between profile markers lung damage. cohort consisted groups subjects mild, moderate, severe illness, 50 examinees each. Forty-four healthy respective age were involved current as control group. Serum evaluated using inductively-coupled plasma mass-spectrometry. Examination demonstrated that heart rate, respiratory body temperature, C-reactive protein levels, well damage increased significantly whereas SpO2 decreased gradually. Increasing severity also associated a significant gradual decrease Ca, Fe, Se, Zn compared controls, Cu especially Cu/Zn ratio elevated. No group differences Mg Mn observed. correlated positively SpO2, being inversely fever, damage, concentrations. Opposite correlations observed for ratio. In regression models, Se independently other anthropometric, biochemical, hemostatic parameters. considered predictor lower adjusted models. Taken together, these findings metabolism interferes pathogenesis, although causal relations precise mechanisms are yet be characterized.

Language: Английский

Citations

85
Relation of Serum Copper Status to Survival in COVID-19 DOI Open Access
Julian Hackler, Raban Heller, Qian Sun

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 1898 - 1898

Published: May 31, 2021

The trace element copper (Cu) is part of our nutrition and essentially needed for several cuproenzymes that control redox status support the immune system. In blood, ferroxidase ceruloplasmin (CP) accounts majority circulating Cu serves as transport protein. Both CP behave positive, whereas serum selenium (Se) its transporter selenoprotein P (SELENOP) negative acute phase reactants. view coronavirus disease (COVID-19) causes systemic inflammation, we hypothesized biomarkers Se are regulated inversely, in relation to severity mortality risk. Serum samples from COVID-19 patients were analysed by total reflection X-ray fluorescence was quantified a validated sandwich ELISA. two correlated positively with (R = 0.42,

Language: Английский

Citations

79
COVID-19 Pandemic as Risk Factors for Excessive Weight Gain in Pediatrics: The Role of Changes in Nutrition Behavior. A Narrative Review DOI Open Access
Hellas Cena, Lauren Fiechtner, Alessandra Vincenti

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(12), P. 4255 - 4255

Published: Nov. 26, 2021

During the coronavirus disease 2019 (COVID-19) pandemic, social isolation, semi-lockdown, and “stay at home” orders were imposed upon population in interest of infection control. This dramatically changes daily routine children adolescents, with a large impact on lifestyle wellbeing. Children obesity have been shown to be higher risk negative weight gain during lockdown. Obesity COVID-19 negatively affect adolescents’ wellbeing, adverse effects psychophysical health, due part food choices, snacking between meals, comfort eating. Moreover, markable decrease physical activity levels an increase sedentary behavior is associated gain, especially excessive weight. In addition, most common comorbidity severe cases COVID-19, suggesting that immune dysregulation, metabolic unbalance, inadequate nutritional status, dysbiosis are key factors complex mechanistic clinical interplay COVID-19. narrative review aims describe up-to-date evidence characteristics focusing role pediatrics. The pandemic has taught us nutrition education interventions, access healthy food, as well family counselling should covered by pediatric services prevent obesity, which worsens outcomes related infection.

Language: Английский

Citations

77
The relevance of magnesium homeostasis in COVID-19 DOI Creative Commons
Valentina Trapani, Aaron J. Rosanoff,

Shadi Baniasadi

et al.

European Journal of Nutrition, Journal Year: 2021, Volume and Issue: 61(2), P. 625 - 636

Published: Oct. 23, 2021

Abstract Purpose In less than one and a half year, the COVID-19 pandemic has nearly brought to collapse our health care economic systems. The scientific research community concentrated all possible efforts understand pathogenesis of this complex disease, several groups have recently emphasized recommendations for nutritional support in patients. scoping review, we aim at encouraging deeper appreciation magnesium clinical nutrition, view vital role numerous links between pathophysiology SARS-CoV-2 infection magnesium-dependent functions. Methods By searching PubMed Google Scholar from 1990 date, review existing evidence experimental studies on chronic non-communicable diseases infectious diseases, focus recent reports alterations homeostasis patients their association with disease outcomes. Importantly, conduct census ongoing trials specifically dedicated disclosing COVID-19. Results Despite many methodological limitations, data seem corroborate an deranged COVID-19, call further better explore prophylactic or therapeutic potential supplementation. Conclusion We propose reconsider relevance magnesium, frequently overlooked practice. Therefore, magnesemia should be monitored and, case imbalanced homeostasis, appropriate regimen supplementation might contribute protect against infection, reduce severity symptoms facilitate recovery after acute phase.

Language: Английский

Citations

73
Assessment of Heavy Metal Concentration in Water, Sediment and Common Fish Species of Dhaleshwari River in Bangladesh and their Health Implications DOI

Evena Parvin Lipy,

Mahmuda Hakim,

Liton Chandra Mohanta

et al.

Biological Trace Element Research, Journal Year: 2021, Volume and Issue: 199(11), P. 4295 - 4307

Published: Jan. 25, 2021

Language: Английский

Citations

70
The Impact of Nutrition on the COVID-19 Pandemic and the Impact of the COVID-19 Pandemic on Nutrition DOI Open Access

Delfin Rodriguez–Leyva,

Grant N. Pierce

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 1752 - 1752

Published: May 21, 2021

The coronavirus disease 2019 (COVID-19) pandemic has had significant morbidity, mortality, social and financial implications for the global population. Despite this knowledge, we still know very little about how COVID-19 infection affects quality of life resulting from changes in nutritional behaviour and, conversely, nutrition could modulate epidemiology COVID-19. In addition, isolation most have experienced due to regulations imposed by governments during may also effects on our behaviour. It is possible that interventions incidence mortality rates. purpose review evaluate current status research topic as it relates pandemic.

Language: Английский

Citations

69
Golgi Metal Ion Homeostasis in Human Health and Diseases DOI Creative Commons
Jie Li, Yanzhuang Wang

Cells, Journal Year: 2022, Volume and Issue: 11(2), P. 289 - 289

Published: Jan. 15, 2022

The Golgi apparatus is a membrane organelle located in the center of protein processing and trafficking pathway. It consists sub-compartments with distinct biochemical compositions functions. Main functions Golgi, including trafficking, glycosylation, sorting, require well-maintained stable microenvironment along metal ion homeostasis. Metal ions, such as Ca2+, Mn2+, Zn2+, Cu2+, are important cofactors many resident glycosylation enzymes. homeostasis ions secretory pathway, which required for proper function stress response tightly regulated maintained by transporters. Mutations transporters cause human diseases. Here we provide review specifically focusing on that maintain under physiological conditions their alterations

Language: Английский

Citations

38
Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review DOI Creative Commons
Lúcia Fátima Campos Pedrosa,

Acsa Nara A. B. Barros,

Lucia Leite‐Lais

et al.

Clinical Nutrition ESPEN, Journal Year: 2021, Volume and Issue: 47, P. 9 - 27

Published: Nov. 6, 2021

Language: Английский

Citations

44
Evaluation of zinc, copper, and Cu:Zn ratio in serum, and their implications in the course of COVID-19 DOI Open Access
Irena Ivanova, Amit Pal, Ilaria Simonelli

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2022, Volume and Issue: 71, P. 126944 - 126944

Published: Feb. 7, 2022

Language: Английский

Citations

37
Comparative Analysis of Serum Zinc, Copper and Magnesium Level and Their Relations in Association with Severity and Mortality in SARS-CoV-2 Patients DOI Open Access

Kiran Kumar PVSN,

Sojit Tomo, Purvi Purohit

et al.

Biological Trace Element Research, Journal Year: 2022, Volume and Issue: 201(1), P. 23 - 30

Published: Jan. 22, 2022

Language: Английский

Citations

35