Journal of Trace Elements in Medicine and Biology, Journal Year: 2023, Volume and Issue: 80, P. 127285 - 127285
Published: Aug. 22, 2023
Language: Английский
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: April 19, 2024
Zinc (Zn) is a vital micronutrient that strengthens the immune system, aids cellular activities, and treats infectious diseases. A deficiency in Zn can lead to an imbalance system. This particularly evident severe cases, where there high susceptibility various viral infections, including COVID-19 caused by SARS-CoV-2. review article examines nutritional roles of human health, maintenance concentration, uptake. As essential trace element plays critical role system necessary for cell function signaling, cells, interleukins, its SARS-CoV-2 infection are further discussed. In summary, this paper encapsulates with hope providing specific insights into research.
Language: Английский
Citations
8
Nutrients, Journal Year: 2022, Volume and Issue: 14(7), P. 1407 - 1407
Published: March 28, 2022
Free zinc is considered to be the exchangeable and biological active form of in serum, discussed a suitable biomarker for alterations body homeostasis related diseases. Given that coronavirus disease 2019 (COVID-19) characterized by marked decrease total serum zinc, clinical data indicate status impacts susceptibility severity infection, we hypothesized free might altered response SARS-CoV-2 infection may reflect severity. To test this hypothesis, concentrations samples survivors nonsurvivors COVID-19 were analyzed fluorometric microassay. Similar reported deficit measured reflection X-ray fluorescence, patients was considerably lower than control subjects, surviving displayed significantly higher levels those (mean ± SD; 0.4 0.2 nM vs. 0.1 nM; p = 0.0004). In contrast recovering (r 0.706, < 0.001) or declining copper−zinc ratio −0.646; 0.001), remained unaltered with time nonsurvivors. particularly low male as compared female 0.0003). This particular interest, sex described risk factor severe COVID-19. Overall, results depressed are associated increased death COVID-19, suggesting serve novel prognostic marker course
Language: Английский
Citations
29
Annals of Medicine and Surgery, Journal Year: 2022, Volume and Issue: 77
Published: April 16, 2022
The COVID-19 pandemic has led to severe financial, clinical, and societal repercussions imposed more pressure on the healthcare system of many nations. impacts immune by causing a systemic inflammatory reaction, often known as cytokine release syndrome (CRS). patients had elevated levels pro-inflammatory cytokines chemokines. In this context, dietary interventions have been utilized mitigate adverse effects regulating excessive secretion Zinc, an anti-inflammatory antioxidant mineral in food with well-established role immunity, is now being employed several clinical studies against COVID-19. Zn deficiency correlated increased production cytokines. As result, we will summarise zinc's immunomodulatory article. We investigate how zinc might contribute poor prognosis disease altering particular
Language: Английский
Citations
24
Journal of Trace Elements in Medicine and Biology, Journal Year: 2022, Volume and Issue: 74, P. 127075 - 127075
Published: Sept. 13, 2022
Language: Английский
Citations
21
Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown
Published: March 7, 2024
Language: Английский
Citations
4
Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 195 - 195
Published: March 30, 2024
The COVID-19 pandemic has brought about diverse impacts on the global population. Individuals with comorbidities were more susceptible to severe symptoms caused by virus. Within crisis scenario, metabolomics represents a potential area of science capable providing relevant information for understanding metabolic pathways associated intricate interaction between viral disease and previous comorbidities. This work aims provide comprehensive description scientific production pertaining within specific context comorbidities, while highlighting promising areas exploration those interested in subject. In this review, we highlighted studies that indicated variety metabolites COVID-19. Furthermore, observed processes involved is limited due urgent need report outcomes individuals overlap two or severity hinders comprehension significance each condition. Most identified are observational, restricted number patients, challenges sample collection amidst emergent situation.
Language: Английский
Citations
4
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
In this review, our objective was to analyze the association between serum magnesium (Mg) levels, Mg supplementation, and coronavirus disease 2019 (COVID-19) outcomes. This systematic review followed Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, searching major databases until February 2023. Twenty-six studies (11,363 patients) were included: 22 examining levels (8474 four investigating supplementations (2889 patients). Most indicated an lower increased COVID-19 severity, including higher mortality rates prolonged recovery periods. Critical patients demonstrated significantly compared moderate/severe cases. However, some reported conflicting findings, with hypermagnesemia also associated poor outcomes in specific patient populations. Regarding dietary intake correlated shorter hospitalization duration faster recovery. supplementation exceeding 450 mg showed potential benefits, antibody titers pregnant women reduced oxygen support requirements elderly when combined vitamins D B12. While evidence suggests a relationship status outcomes, findings are heterogeneous. Further investigation through well-designed clinical trials is required gain deeper insights into role of pathophysiology therapeutic supplementation.
Language: Английский
Citations
0
Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: 88, P. 127625 - 127625
Published: Feb. 27, 2025
Language: Английский
Citations
0
Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114355 - 114355
Published: March 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 30, 2025
Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has affected hundreds of millions people globally, resulting in deaths. During this pandemic, children have demonstrated greater resistance than adults, exhibiting lower infection rates, reduced mortality, and milder symptoms. Summarizing the differences between adults during COVID-19 can provide insights into protective mechanisms potential implications for future treatments. In review, we focused on summarizing discussing better protection COVID-19. These encompass several factors: baseline expression cell surface receptor ACE2 hydrolase TMPRSS2, impact complications COVID-19, age-related cytokine profiles. Additionally, local systemic immune responses also contribute significantly, particularly interferon responses, heterologous from non-COVID-19 vaccinations, status variations influenced micronutrient levels. The advantageous these may prevention treatment Importantly, while metabolic profiles differential vaccine to children, current comparative research remains limited requires further investigation.
Language: Английский
Citations
0