Staging classification of omicron variant SARS-CoV-2 infection based on dual-spectrometer LIBS (DS-LIBS) combined with machine learning DOI Creative Commons
Weiliang Wang,

Shengqun Shi,

Yuanchao Liu

et al.

Optics Express, Journal Year: 2023, Volume and Issue: 31(25), P. 42413 - 42413

Published: Nov. 16, 2023

Effective differentiation of the infection stages omicron can provide significant assistance in transmission control and treatment strategies. The combination LIBS serum detection machine learning methods, as a novel disease auxiliary diagnostic approach, has high potential for rapid accurate staging classification Omicron infection. However, conventional single-spectrometer methods focus on detecting spectra major elements, while trace elements are more closely related to progression COVID-19. Here, we proposed analytical method with dual-spectrometer (DS-LIBS) assisted classify different omicron. DS-LIBS, including broadband spectrometer narrowband spectrometer, enables synchronous collection elemental serum, respectively. By employing RF models, accuracy using data collected from DS-LIBS reach 0.92, compared 0.84 0.73 when LIBS. This improvement highlights efficacy approach. Then, performance four SVM, RF, IGBT, ETree, is compared. ETree demonstrates best, cross-validation test set accuracies 0.94 0.93, Additionally, it achieves 1.00, 0.89 B1-acute, B1-post, B2, B3. Overall, results demonstrate that combined model effective

Language: Английский

Free Zinc as a Predictive Marker for COVID-19 Mortality Risk DOI Open Access
Maria Maares, Julian Hackler,

Alessia Haupt

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(7), P. 1407 - 1407

Published: March 28, 2022

Free zinc is considered to be the exchangeable and biological active form of in serum, discussed a suitable biomarker for alterations body homeostasis related diseases. Given that coronavirus disease 2019 (COVID-19) characterized by marked decrease total serum zinc, clinical data indicate status impacts susceptibility severity infection, we hypothesized free might altered response SARS-CoV-2 infection may reflect severity. To test this hypothesis, concentrations samples survivors nonsurvivors COVID-19 were analyzed fluorometric microassay. Similar reported deficit measured reflection X-ray fluorescence, patients was considerably lower than control subjects, surviving displayed significantly higher levels those (mean ± SD; 0.4 0.2 nM vs. 0.1 nM; p = 0.0004). In contrast recovering (r 0.706, < 0.001) or declining copper−zinc ratio −0.646; 0.001), remained unaltered with time nonsurvivors. particularly low male as compared female 0.0003). This particular interest, sex described risk factor severe COVID-19. Overall, results depressed are associated increased death COVID-19, suggesting serve novel prognostic marker course

Language: Английский

Citations

29
Gustatory and Saliva Secretory Dysfunctions in COVID-19 Patients with Zinc Deficiency DOI Creative Commons
Hironori Tsuchiya

Life, Journal Year: 2022, Volume and Issue: 12(3), P. 353 - 353

Published: Feb. 28, 2022

Given the ever-progressing studies on coronavirus disease 2019 (COVID-19), it is critical to update our knowledge about COVID-19 symptomatology and pathophysiology. In present narrative review, oral symptoms were overviewed using latest data their pathogenesis was hypothetically speculated. PubMed, LitCovid, ProQuest, Google Scholar searched for relevant from 1 April 2021 with a cutoff date of 31 January 2022. The literature search indicated that gustatory dysfunction saliva secretory are prevalent in patients both dysfunctions persist after recovery disease, suggesting pathogenic mechanism common these cooccurring symptoms. characterized by hypozincemia, which zinc possibly redistributed blood liver at expense other tissues. If induces intracellular deficiency, activity zinc-metalloenzyme carbonic anhydrase localized taste buds salivary glands may be influenced adversely affect functions. Zinc-binding metallothioneins transporters, cooperatively control cellular homeostasis, expressed tissues participating secretion. Their expression dysregulation associated COVID-19-induced deficiency have some effect Zinc supplementation expected improve patients.

Language: Английский

Citations

20
Zinc and selenium status in coronavirus disease 2019 DOI Open Access

Liding Fan,

Yanshuo Cui,

Zonghao Liu

et al.

BioMetals, Journal Year: 2023, Volume and Issue: 36(5), P. 929 - 941

Published: April 20, 2023

Language: Английский

Citations

11
Zinc(II) Complexes: Synthetic and antiviral Perspective DOI

Pratima Kumari,

Arpan Das, Aman Kumar

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114355 - 114355

Published: March 1, 2025

Language: Английский

Citations

0
Immunomodulatory Role of Microelements in COVID-19 Outcome: a Relationship with Nutritional Status DOI Open Access
Roldán-Bretón Nuria Renata, Anna González-Rascón, Ana Gabriela Leija-Montoya

et al.

Biological Trace Element Research, Journal Year: 2022, Volume and Issue: 201(4), P. 1596 - 1614

Published: June 6, 2022

Language: Английский

Citations

18
Comparison of plasma mitochondrial DNA copy number in asymptomatic and symptomatic COVID-19 patients DOI Creative Commons
Shahrzad Shoraka, Seyed Reza Mohebbi, Seyed Masoud Hosseini

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 6, 2023

Introduction Since the beginning of COVID-19 pandemic, a wide clinical spectrum, from asymptomatic infection to mild or severe disease and death, have been reported in patients. Studies suggested several possible factors, which may affect outcome COVID-19. A pro-inflammatory state impaired antiviral response as major contributing factors Considering that mitochondria an important role regulating immune responses pathogens, signaling, cell it has received much attention SARS-CoV-2 infection. Recent studies demonstrated high levels cell-free mitochondrial DNA ( cf -mtDNA) are associated with increased risk intensive care unit (ICU) admission mortality. However, there few on -mtDNA infection, mainly focusing critically ill cases. In present study, we investigated copy number patients compared between symptomatic cases, assessed values. We also determined -nuclear -nDNA) transcription factor (TFAM) mRNA level studied groups. Materials methods Plasma buffy coat samples were collected 37 33 controls. Briefly, after total extraction, plasma -mtDNA, -nDNA numbers measured by absolute qPCR using standard curve method. Furthermore, RNA extraction cDNA synthesis, TFAM evaluated qPCR. Results The results showed statistically significantly higher than cases p value = 0.01). 0.00). There was no significant difference these two groups &gt; 0.05). Also, good diagnostic potential subgroups. Conclusion is probably due its inflammation response. It can be promising candidate biomarker for diagnosis Further investigation will help understanding pathophysiology effective therapeutic strategies.

Language: Английский

Citations

8
A comparative study of serum Zn, Cu, Mg, Mn, Cr, and Fe levels and their association with the vulnerability of Iraqi COVID-19 patients DOI Open Access
Falah S. Al-Fartusie,

Safaa I. Kader,

Sara Jassim Mohammed

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2023, Volume and Issue: 79, P. 127242 - 127242

Published: June 12, 2023

Language: Английский

Citations

7
Circulating trace elements status in COVID-19 disease: A meta-analysis DOI Creative Commons
Yunhui Li,

Weihe Luo,

Bin Liang

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Aug. 12, 2022

Trace elements are a group of essential metals or metalloids, which necessary for life, and present in minute amounts. Despite substantial researches highlighting the importance trace Coronavirus disease 2019 (COVID-19) diseases, thorough evaluation levels circulating is lacking. Therefore, we conducted systematic review meta-analysis to evaluate element status (Zn, Fe, Cu, Mg, Se) COVID-19 disease. We also assessed relationship between severity survival during follow-up. searched comprehensively MEDLINE, Web Science, CNKI, WangFang databases without language restriction, November 1, April 2022. The search identified 1,566 preliminary references. A total 49 studies met eligibility criteria were included review, 42 final meta-analysis. Meta-analysis showed that patients had significantly lower Zn (SMD: -0.83, 95% CI: -1.19 -0.46, P < 0.001), Fe -1.56, -2.90 -0.21, = 0.023), Se -0.75, -0.94 -0.56, 0.001) than healthy controls, -0.47, -0.75 -0.18, 0.002), -0.45, -0.79 -0.12, 0.008), -0.27, -0.49 -0.04, 0.020) associated with presence patients. Moreover, non-survivors survivors -0.28, -0.44 0.001). However, there was no significant difference Cu Mg non-severity status, (all > 0.05). Taken together, displayed Zn, Se, their status. may provide part explanation unfavorable presumed optimistically supplements might an adjutant treatment early stages COVID-19.[https://www.crd.york.ac.uk/prospero], identifier [CRD42022348599].

Language: Английский

Citations

10
Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies DOI Creative Commons
Roberto Ambra,

Sahara Melloni,

Eugenia Venneria

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(10), P. 4130 - 4130

Published: May 16, 2023

The purpose of this review is to systematically examine the scientific evidence investigating selenium's relationship with COVID-19, aiming support, or refute, growing hypothesis that supplementation could prevent COVID-19 etiopathogenesis. In fact, immediately after beginning pandemic, several speculative reviews suggested selenium in general population act as a silver bullet limit even disease. Instead, deep reading reports on and are available date supports neither specific role severity, nor its prevention disease onset, etiology.

Language: Английский

Citations

6
COVID-19 Oral Sequelae: Persistent Gustatory and Saliva Secretory Dysfunctions after Recovery from COVID-19 DOI Creative Commons
Hironori Tsuchiya

Medical Principles and Practice, Journal Year: 2023, Volume and Issue: 32(3), P. 166 - 177

Published: Jan. 1, 2023

Diverse manifestations have been recognized to last for a long time in patients infected with SARS-CoV-2. However, understanding of oral sequelae after recovery from COVID-19 is relatively poor compared that symptoms the acute phase and other sequelae. The aim present study was characterize persistent gustatory saliva secretory dysfunctions speculate on their pathogenic mechanisms. Articles were retrieved by searching scientific databases cutoff date September 30, 2022. literature search indicated ageusia/dysgeusia xerostomia/dry mouth are reported 1–45% survivors at follow-ups 21–365 days 2–40% 28–230 days, respectively. prevalence partly depends difference ethnicity, gender, age, disease severity subjects. Co-occurring pathogenically related either or both following: expression SARS-CoV-2 cellular entry-relevant receptors taste buds salivary glands, infection-induced deficiency zinc essential normality perception secretion. Given long-term sequelae, hospital discharge not end disease; therefore, careful attention should be continuously paid conditions post-COVID-19 patients.

Language: Английский

Citations

6