Research Square (Research Square),
Journal Year:
2022,
Volume and Issue:
unknown
Published: Oct. 4, 2022
Abstract
Lead
(Pb)
is
a
corrosion-resistant,
heavy,
non-ferrous
metal
with
widespread
environmental
pollution.
Several
chelators
have
been
used
in
the
treatment
of
Pb
poisoning.
However,
effect
sodium
para-aminosalicylic
acid(PAS-Na)on
excretion
has
yet
to
be
reported.
To
investigate
effects
PAS-Na
on
excretion,
mouse
model
acute
lead
exposure
was
established.
Healthy
mice
(90)
received
abdominal
injection
(i.p.)
120
mg/kg
acetate,
and
4
h
later
80,
160,
240
PAS-Na,
or
edetate
calcium
disodium
(CaNa
2
EDTA)
were
injected
subcutaneously
(s.c.)
once
per
day
for
6
days
into
corresponding
groups,
respectively.
The
Control,
Pb-exposed,
CaNa
EDTA
groups
evaluated
simultaneously.
After
collecting
24
urine
samples,
animals
sacrificed
batches
2nd,
4th,
6th
day.
Levels
other
elements
[including
manganese
(Mn)
copper
(Cu)]
urine,
whole
blood
brain
tissues
analyzed
by
graphite
furnace
atomic
absorption
spectrometry
(AAS).
results
showed
that
increased
levels
mice,
afforded
antagonistic
against
Pb-induced
toxicity.
While
additional
studies
will
needed,
these
novel
establish
as
potential
efficacious
mitigating
Redox Biology,
Journal Year:
2023,
Volume and Issue:
69, P. 102990 - 102990
Published: Dec. 9, 2023
Alzheimer's
disease
(AD)
is
a
common
neurodegenerative
that
associated
with
multiple
environmental
risk
factors,
including
heavy
metals.
Lead
(Pb)
metal
contaminant,
which
closely
related
to
the
incidence
of
AD.
However,
research
on
role
microglia
in
Pb-induced
AD-like
pathology
limited.
To
determine
mechanism
by
Pb
exposure
aggravates
AD
progression
and
microglial
activation,
we
exposed
APP/PS1
mice
Aβ
Gut,
Journal Year:
2024,
Volume and Issue:
unknown, P. gutjnl - 332523
Published: Aug. 23, 2024
Epidemiological
and
translational
data
increasingly
implicate
environmental
pollutants
in
inflammatory
bowel
disease
(IBD).
Indeed,
the
global
incidence
of
IBD
has
been
rising,
particularly
developing
countries,
parallel
with
increased
use
chemicals
synthetic
materials
daily
life
escalating
pollution
levels.
Recent
nationwide
ecological
studies
have
reported
associations
between
agricultural
pesticides
IBD,
Crohn’s
disease.
Exposure
to
other
chemical
categories
also
linked
an
risk
IBD.
To
synthesise
available
identify
knowledge
gaps,
we
conducted
a
systematic
review
human
that
on
impact
outcomes.
Furthermore,
summarised
vitro
animal
investigating
mechanisms
underlying
these
associations.
The
32
included
corroborate
heavy
transition
metals,
except
zinc,
air
pollutants,
per-
polyfluorinated
substances,
are
associated
exposure
being
disease-related
adverse
outcomes
as
well.
narrative
preclinical
suggests
several
overlapping
associations,
including
intestinal
permeability,
systemic
inflammation
dysbiosis.
A
consolidated
understanding
exposures
is
key
identification
potentially
modifiable
factors
inform
strategies
towards
prediction,
prevention
mitigation
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: April 14, 2023
Background
Although
several
studies
have
examined
the
relationships
between
lead
(Pb)
exposure
and
serum
lipid
profiles,
associations
of
metal
mixture,
including
essential
metals
with
remain
unclear.
Objective
To
investigate
mixture
Pb
[magnesium
(Mg),
manganese
(Mn),
copper
(Cu),
iron
(Fe),
zinc
(Zn),
calcium
(Ca)]
profiles
[total
cholesterol
(TC),
triglyceride
(TG),
low-density
lipoprotein
(LDL-C),
high-density
(HDL-C)],
as
well
potential
interactions
among
metals.
Methods
Nine
hundred
ninety-eight
Chinese
community-dwelling
adults
completed
a
questionnaire
underwent
checkups
anthropometric
parameters,
profile
levels
(TC,
TG,
LDL-C,
HDL-C),
blood
concentrations
(Pb,
Mg,
Mn,
Cu,
Fe,
Zn,
Ca).
The
multivariable
linear
regression,
weighted
quantile
sum
(WQS)
Bayesian
kernel
machine
regression
(BKMR)
were
applied
to
evaluate
single
combined
profiles.
Results
In
model,
was
positively
associated
TC,
HDL-C
(
p
<
0.05,
all),
Mg
Ln
TG
all).
WQS
BKMR
models,
all
addition,
an
inverse
U-shaped
association
positive
interactive
effect
on
TC
LDL-C
found.
Conclusion
Pb,
together
metals,
especially
levels,
are
suggested
be
considered
when
assessing
dyslipidemia
risk.
However,
more
evidence
is
still
needed
validate
conclusions.
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
265, P. 115528 - 115528
Published: Sept. 30, 2023
This
research
aimed
to
approach
relationships
between
metal
mixture
in
blood
and
kidney
function,
tumor
necrosis
factor
alpha
(TNF-α)
by
machine
learning.
Metals
levels
were
measured
Inductively
Couple
Plasma
Mass
Spectrometry
from
421
participants.
We
applied
K
Nearest
Neighbor
(KNN),
Naive
Bayes
classifier
(NB),
Support
Vector
Machines
(SVM),
random
forest
(RF),
Gradient
Boosting
Decision
Tree
(GBDT),
Categorical
boosting
(CatBoost),
eXtreme
(XGBoost),
Whale
Optimization-based
XGBoost
(WXGBoost)
identify
the
effect
of
plasma
metals,
TNF-α,
estimated
glomerular
filtration
rate
(eGFR
CKD-EPI
equation).
conducted
not
only
toxic
lead
(Pb),
arsenic
(As),
cadmium
(Cd)
but
also
included
trace
essential
selenium
(Se),
copper
(Cu),
zinc
(Zn),
cobalt
(Co),
predict
interaction
TNF-α/white
count,
eGFR.
The
high
average
TNF-α
level
group
was
observed
among
subjects
with
higher
Pb,
As,
Cd,
Cu,
Zn
blood.
No
associations
shown
low
Se
Co
levels.
Those
lower
eGFR
had
Co,
crucial
predictor
metals
then
Se,
Co.
learning
revealed
that
As
major
role
predictors
after
feature
selection.
function
modified
co-exposure
metals.
able
acquire
highest
accuracy
over
85%
multi-metals
exposure
model.
Pb
strongest
declined
In
addition,
Cd
synergistic
prediction
model
TNF-α.
explored
potential
approaches
for
predicting
health
outcomes
multi-metal
exposure.
added
SHAP
could
give
an
explicit
explanation
individualized
precision
risk
insight
key
features
