Overview of Some Biochemical Parameters in Parkinson’s Disease DOI
Veysel Tahiroğlu, İlhami Gülçın

Published: June 10, 2024

Parkinson disease is a neurodegenerative that affects dopaminergic neurons in the substantia nigra. Parkinson’s occurs with unwanted and uncontrolled movements, causing balance coordination difficulties, resulting tremor paralysis. Due to symptoms such as tremors, significantly person’s quality of life can worsen if left untreated. In this section, relationship between important biochemical parameters dopamine, insulin resistance, vitamin D, glycemic index, cholesterol, proteins minerals, which have very roles prognosis treatment process Parkinson, evaluated. We believe clinicians manage more efficiently effectively by taking into account points expressed section every disease.

Language: Английский

Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases DOI Creative Commons
Leilei Chen, Qingqing Shen, Yingjuan Liu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 2, 2025

Language: Английский

Citations

8
The mechanism of cuproptosis in Parkinson’s disease DOI
Min Huang,

Yong Zhang,

Xuehong Liu

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102214 - 102214

Published: Feb. 2, 2024

Language: Английский

Citations

12
Bridging the gap between theory and treatment: Transition metal complexes as successful candidates in medicine DOI

Sara Abdolmaleki,

Alireza Aliabadi, Samad Khaksar

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 531, P. 216477 - 216477

Published: Feb. 8, 2025

Language: Английский

Citations

1
Obesity-related indices are associated with self-reported infertility in women: findings from the National Health and Nutrition Examination Survey DOI Creative Commons
Hong Zhang, Minmin Yu, Li Li

et al.

Journal of International Medical Research, Journal Year: 2025, Volume and Issue: 53(2)

Published: Feb. 1, 2025

Objective Obesity can contribute to infertility, but the exact relationship between infertility risk and obesity-related measurements like waist-to-height ratio (WHtR), body roundness index (BRI), conicity (CoI), A shape (ABSI) in women is uncertain. We investigated association these indices female infertility. Methods In this cross-sectional study, we used National Health Nutrition Examination Survey data (2013–2018). weighted multivariable logistic regression analysis, receiver operating characteristic (ROC) curves, subgroup as well propensity score matching. Results Among 3373 participants, 344 (10.2%) reported significant link higher increased WHtR, BRI, CoI, ABSI, mass (BMI) was found. Multivariable analysis showed WHtR (odds [OR] = 1.27, 95% confidence interval [CI]: 1.14–1.42), BRI (OR 1.09, CI: 1.05–1.14), CoI 1.36, 1.18–1.56), ABSI 1.22, 1.12–1.33), BMI 1.03, 1.02–1.05) were significantly associated with had best diagnostic performance (area under ROC curve 0.628, 0.597–0.658). Conclusions Obesity-related positively linked among United States. These serve valuable tools for assessing risk.

Language: Английский

Citations

1
Dietary vitamin E intake and risk of Parkinson's disease: a cross-sectional study DOI Creative Commons

Xiaoqian Hao,

Haiyan Li, Qinglian Li

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 5, 2024

Objective Current evidence on the association between dietary vitamin E intake and risk of Parkinson's disease (PD) is limited. The aim study was to explore with PD in United States among adults over 40 years. Methods We conducted a cross-sectional data collected from National Health Nutrition Examination Survey (NHANES) 2009 2018. A total sample 13,340 participants were included. To identify different characteristics participants, we utilized propensity score matching (PSM) reduce effects selection bias confounding variables. Weighted univariate multivariable logistic regression used examine before after matching. Then, restricted cubic spline (RCS) visually describe possible non-linear relationships. Finally, employed subgroup analysis further investigate relationship PD. Results According weighted analysis, inversely associated results RCS revealed no inverse showed that age may influence negative ( P < 0.05 for interaction). Conclusion Among years age, negatively Our support supplementation be as an intervention strategy occurrence

Language: Английский

Citations

6
Association between serum potassium and Parkinson’s disease in the US (NHANES 2005–2020) DOI Creative Commons

Xue Zhou,

Jingtong Zhao,

Yang Liu

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 9, 2024

Evaluating the correlation between serum potassium and Parkinson's disease (PD) in US adults.

Language: Английский

Citations

4
Association of dietary selenium intake and all-cause mortality of Parkinson’s disease and its interaction with blood cadmium level: a retrospective cohort study DOI Creative Commons

Xinyu Tu,

Na Wu,

Ying Wan

et al.

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 10, 2024

Abstract Background Parkinson’s disease (PD) is a slowly progressive neurodegenerating that may eventually lead to disabling condition and pose threat the health of aging populations. This study aimed explore association two potential risk factors, selenium cadmium, with prognosis as well their interaction effect. Methods Data were obtained from National Health Nutrition Examination Survey (NHANES) 2005–2006 2015–2016 Death Index (NDI). Participants classified patients by self-reported anti-Parkinson medications usage. Cox regression models restricted cubic spline applied evaluate between PD mortality intake level blood cadmium level. Subgroup analysis was also conducted them. Results A total 184 individuals included. In full adjusted cox model (adjusted for age, gender, race, hypertension, pesticide exposure, smoking status caffeine intake), compared participants low intake, those normal significantly associated less death (95%CI: 0.18–0.76, P = 0.005) while no significant found group high 0.16–1.20, 0.112). Restricted indicated nonlinear relationship (P nonlinearity 0.050). The not 0.19–5.57, However, term showed significance in 0.048). protective effect existed populations but cadmium. Conclusion Moderate increase had on especially

Language: Английский

Citations

4
A Novel Coumarin Based Fluorescent Probe for Cu²⁺ Detection as well as Applications DOI

Yunke Gao,

Linlong Deng, Lei Xue

et al.

Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Language: Английский

Citations

0
The association of visceral fat metabolism score with hyperuricemia—evidence from NHANES 1999–2018 DOI Creative Commons
Lin Xie, Haiyan Qu,

Dandan Lai

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 10, 2025

Despite substantial evidence that visceral obesity is an epidemiological risk factor for hyperuricemia (HUA), studies on the connection between Metabolic Score Visceral Fat (METS-VF) and HUA remain insufficient. This research focused METS-VF's potential role as a HUA. Notably, 8,659 participants from National Health Nutrition Examination Survey (NHANES) 1999 to 2018 were enrolled in this study. Propensity score matching (PSM), multivariate logistic regression analysis, subgroup interaction test, restricted cubic spline (RCS) analysis implemented identify correlation METS-VF In fully adjusted model, results of multiple indicated was related elevated prevalence [before PSM: odds ratio (OR) = 3.51 (2.88, 4.27), p < 0.001; after OR 2.90 (2.36, 3.58), 0.001]. RCS non-linear positive observed incidence (before p-non-linear <0.001; 0.0065). Subgroup tests revealed impact modified by sex ethnicity. There significant adults United States. could serve valuable metric assessing development progression

Language: Английский

Citations

0
Exploring the link between estimated glucose disposal rate and Parkinson’s disease: cross-sectional and mortality analysis of NHANES 2003–2016 DOI Creative Commons
Xiaoting Li, Zhaohao Zeng

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 4, 2025

Objectives To investigate the association between estimated glucose disposal rate (eGDR), a surrogate marker of insulin resistance, and Parkinson’s disease (PD) risk, to examine relationship eGDR all-cause mortality among PD patients. Methods Using data from National Health Nutrition Examination Survey (NHANES) 2003–2016, we conducted cross-sectional study 20,767 participants aged ≥40 years. was calculated using waist circumference, hypertension status, HbA1c levels. cases were identified through anti-parkinsonian medication use. The examined weighted logistic regression models with progressive adjustment for potential confounders. Survival analysis performed in 255 patients assess mortality. Results Among participants, 256 had (weighted prevalence: 1.23%). Higher associated lower odds crude (OR: 0.906, 95% CI: 0.856–0.960, P &lt; 0.001). After full adjustment, highest tertile showed significantly compared lowest 0.574, 0.337–0.976, = 0.040). Restricted cubic spline revealed significant M-shaped non-linear risk (P non-linearity In survival analysis, higher (adjusted HR: 0.875, 0.775–0.987, 0.030), an inverted U-shaped observed 0.0352). Conclusion levels are better patients, suggesting that sensitivity might play role pathogenesis progression. These findings highlight importance metabolic health PD.

Language: Английский

Citations

0