INTEGRATING PHYTOCHEMISTRY WITH ONCOLOGY: THE ROLE OF ALOE VERA NANOPARTICLES IN COMBATING ORAL CANCER TUMOR GROWTH: IN VIVO RAT MODELS

Published: Jan. 17, 2025

Background: Oral cancer, a major public health challenge, often exhibits poor prognosis due to resistance conventional therapies. Integrating plant-derived nanotherapeutics, such as Aloe vera nanoparticles (AVNPs), offers promising alternative approach. possesses anti-inflammatory, pro-apoptotic, and anti-tumor properties, which can be enhanced through nanoparticle synthesis. This study explores the anti-cancer potential of AVNPs in reducing oral cancer tumor growth using vivo models. Objective: To investigate therapeutic efficacy inducing apoptosis chemically induced rat model. Methods: gel was processed under aseptic conditions, freeze-dried, synthesized into green synthesis Characterization performed Scanning Electron Microscopy (SEM) Dynamic Light Scattering (DLS). Sprague-Dawley rats 4-nitroquinoline 1-oxide (4NQO) drinking water (20 ppm) over eight weeks. Rats were divided four groups: control, low-dose mg/kg), high-dose (40 mg/kg). Tumor inhibition evaluated macroscopically histopathologically. Cellular viability assessed MTT assay, gene expression levels Caspase-3 Caspase-9 analyzed quantitative PCR. Results: exhibited an IC50 13.1 µM assay. volume decreased significantly treated groups compared control group. Relative showed upregulation pro-apoptotic markers, with at 12.3 14.8. These results confirm suppression by AVNPs. Conclusion: demonstrated significant Their natural chemotherapeutics warrants further clinical research for applications.

Language: Английский

Chitosan membranes incorporating Aloe vera glycolic extract with joint synthesis of silver nanoparticles for the treatment of skin lesions

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 15(4), P. 1376 - 1392

Published: July 30, 2024

New wound dressings based on polymeric membranes have been widely exploited for clinical applications to assist in the healing process and prevent additional complications (e.g., bacterial infections). Here we propose development of a new production method chitosan, incorporating glycolic extract Aloe vera with joint synthesis silver nanoparticles use as bioactive dressing. The were obtained by casting technique, their morphological, physicochemical characteristics, degree swelling, degradation profile antimicrobial activity evaluated. Morphological analyzes confirmed presence membrane. chemical compatibility between materials was demonstrated through thermal analysis (TGA DSC) combined ATR-FTIR tests, showing complexation (Mb-Ch-Ex.Av-NPs). All characterized hydrophilic material (with contact angle (ө) < 90°); however, highest swelling chitosan. (Mb-Ch) membrane (69.91 ± 5.75%) lowest Mb-Ch-Ex.Av-NPs (26.62 8.93%). On other hand, higher (77.85 7.51%) lower Mb-Ch (57.60 2.29%). manufactured showed against Escherichia coli Staphylococcus aureus. Our work translucent flexible chitosan-based membranes, dressing, proven activity.

Language: Английский

Methanolic extracts of litchi (Litchi chinensis Sonn.): A novel approach of targeting glucose-6-phosphate dehydrogenase for liver cancer therapy

Toxicon, Journal Year: 2024, Volume and Issue: 248, P. 108047 - 108047

Published: July 26, 2024

Language: Английский