Zinc Deficiency: Impact on Growth, Immunity, and the Role of Plant‐Based Nutritional Strategies DOI
Ashish Majumdar,

Surendra Saraf,

Chandrashekhar Sahu

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

Zinc is a vital micronutrient that plays key role in our growth, development, and immune health. deficiency significant health issue around the globe, especially affecting vulnerable groups like children, pregnant women, older adults. This review emphasizes serious effects of zinc deficiency, which weakens system, increases risk infections, slows negatively affects cognitive motor skills. Studies show taking can boost health, reduce severity help with developmental challenges. Plant-based solutions, particularly regions where animal-based diets are limited, provide sustainable ways to tackle deficiency. Foods rich nutrients, chickpeas, spinach, pumpkin seeds, along biofortified grains such as wheat rice, significantly intake. Moringa leaves, amaranth, guava bodies absorb more effectively. Despite progress, challenges remain, phytates reducing availability risks linked excessive consumption. In future, it would be beneficial for researchers explore how plant-based supplements, dietary inhibitors, genetic factors influence metabolism. It's important create biofortification personalized treatments people need.

Language: Английский

Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions DOI Creative Commons
Héctor Vázquez‐Lorente, Lourdes Herrera‐Quintana, Laura Jiménez-Sánchez

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 996 - 996

Published: Aug. 17, 2024

Evidence is increasing that vitamin D and CYP11A1-derived D, tachysterol, lumisterol metabolites play a significant antioxidant role beyond its classical functions in bone health calcium metabolism. Several recent studies have linked these elements to reduced oxidative stress as well improved immune, cardiovascular, neurological result of chronic kidney disease cancer. Additionally, supplementation with this has been shown be one the most cost-effective micronutrient interventions worldwide, highlighting potential therapeutic approach. The underlying mechanisms implications function or are not understood. This comprehensive narrative review aimed at summarizing current evidence regarding molecular implicated provide general overview identify key research areas for future, offering an extensive perspective can guide both researchers clinicians management diseases associated and/or insufficient status.

Language: Английский

Citations

5
Nutritional Habits in Crohn’s Disease Onset and Management DOI Open Access
Konstantinos Papadimitriou, Georgia-Eirini Deligiannidou, Gavriela Voulgaridou

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 559 - 559

Published: Jan. 31, 2025

Crohn's disease (CD)'s activation factors are still unclear. However, they reported to involve an interaction between genetic susceptibility and unhealthy lifestyle like smoking, alcohol consumption, low physical activity, BMI (<18.5 kg/m2), probably unbalanced nutritional habits. Therefore, the aim of present review is demonstrate possible effects different habits, before occurrence disease, as crucial for inception CD activation. The structure narrative was conducted following instructions "Review Academy Nutrition Dietetics Checklist". It well established that consumption specific foods drinks, such spicy fatty foods, raw vegetables fruits, dairy products, carbonated beverages, coffee or tea, can provoke exacerbation symptoms. On other hand, Mediterranean-oriented diets seem provide inverse association with incidence CD. Moreover, patients have knowledge select contribute remission their it not clearly whether onset due lifelong habits subsequent effect on gut microbiota secretion, which seems be gold standard CD's investigation. more future studies should record, examine, compare (immediately after disease's diagnosis) healthy populations in a manner, order reveal influence onset.

Language: Английский

Citations

0
Vitamin D Status and Incidence of SARS-CoV-2 Reinfections in the Borriana COVID-19 Cohort: A Population-Based Prospective Cohort Study DOI Creative Commons

Salvador Domènech-Montoliu,

Laura López-Diago,

Isabel Aleixandre-Górriz

et al.

Tropical Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: 10(4), P. 98 - 98

Published: April 6, 2025

A deficient vitamin D (VitD) status has been associated with SARS-CoV-2 infections, severity, and mortality. However, this related to reinfections studied little. Our aim was quantify the risk of considering VitD before reinfection. We performed a population-based prospective cohort study in Borriana (Valencia Community, Spain) during 2020-2023, measuring 25-hydroxyvitamin [25(OH)D] levels by electrochemiluminescence. Cox proportional hazards models were employed. Of total 644 cases confirmed laboratory tests, 378 (58.9%) included our study, an average age 38.8 years; 241 females (63.8%), 127 occurred (33.6%). reinfection incidence rates per 1000 person-days 0.50 for (<20 ng/mL), insufficient (20-29 0.37 sufficient (≥30 ng/mL). Compared status, adjusted hazard ratios 1.79 (95% confidence interval [CI] 0.89-3.59) 1.59 CI 1.06-2.38) significant inverse dose-response (p = 0.02). These results can help improve nutritional actions against reinfections. suggest that lower than 30 ng/mL showed higher Achieving maintaining is recommended prevent

Language: Английский

Citations

0
Current perspectives on malnutrition and immunomodulators bridging nutritional deficiencies and immune health DOI Creative Commons
Ashish Majumdar,

Surendra Saraf,

Chandrashekhar Sahu

et al.

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 24, 2025

Abstract Background Malnutrition is still one of the most serious and prevalent worldwide health problems, especially found in low- middle-income countries, which impairs immune functions increases susceptibility to infection. This study investigates complex association between malnutrition dysfunction, role immunomodulators restoring function. analyzes different types malnutrition, including protein-energy micronutrient deficiencies, their consequences system through inhibited cytokine cell production. Main body Immunomodulators, include natural agents such as phytochemicals probiotics, well synthetic agents, may help reduce dysfunction related starvation. article categorizes these discusses mechanisms action, regulating inflammatory pathways, increasing generation cells, augmenting global response. In addition, therapeutic approaches utilizing immunomodulation conjunction with nutritional therapies, supplementation (vitamins A, C, D zinc) or immunomodulators, improve gastroenterological disease states are discussed. Case reports recent studies provided that provide evidence supporting effectiveness therapy clinical outcomes vulnerable populations. Conclusion While there a promise for safety, long-term efficacy, ethical issues address before they could widely be employed. Each step research calls applied, working example immunomodulatory medicine tailored programs internationally. The highlights vital treatment encourages holistic immunological worldwide.

Language: Английский

Citations

0
Zinc Deficiency: Impact on Growth, Immunity, and the Role of Plant‐Based Nutritional Strategies DOI
Ashish Majumdar,

Surendra Saraf,

Chandrashekhar Sahu

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

Zinc is a vital micronutrient that plays key role in our growth, development, and immune health. deficiency significant health issue around the globe, especially affecting vulnerable groups like children, pregnant women, older adults. This review emphasizes serious effects of zinc deficiency, which weakens system, increases risk infections, slows negatively affects cognitive motor skills. Studies show taking can boost health, reduce severity help with developmental challenges. Plant-based solutions, particularly regions where animal-based diets are limited, provide sustainable ways to tackle deficiency. Foods rich nutrients, chickpeas, spinach, pumpkin seeds, along biofortified grains such as wheat rice, significantly intake. Moringa leaves, amaranth, guava bodies absorb more effectively. Despite progress, challenges remain, phytates reducing availability risks linked excessive consumption. In future, it would be beneficial for researchers explore how plant-based supplements, dietary inhibitors, genetic factors influence metabolism. It's important create biofortification personalized treatments people need.

Language: Английский

Citations

0