International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3594 - 3594
Published: March 22, 2024
The placenta is a transient but essential organ for normal in utero development, playing several functions pregnancy [...].
Language: Английский
Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Chemical Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
A multi-rotor-based ER targeting fluorescent probe was rationally constructed. It has been successfully utilized to assess viscosity changes during starvation-induced ER-phagy.
Language: Английский
Citations
0
Applied Materials Today, Journal Year: 2025, Volume and Issue: 44, P. 102697 - 102697
Published: March 30, 2025
Language: Английский
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Research in Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 20(2), P. 165 - 187
Published: March 1, 2025
Despite great advances in cancer identification and treatment, malignancies remain the primary cause of high morbidity mortality worldwide. The drawbacks conventional chemotherapy, such as severe toxicity, lack specificity related to actively dividing cells, resistance, can warrant urgent need develop an alternative approach treat this disease. To overcome drawbacks, researchers are attempting deliver drugs site action (targeted delivery) or identify that specifically target tumor cells. In regard, highly cationic amphipathic antimicrobial peptides attracting attention due their potent anticancer activity, low cost manufacture, and, most critically, tumor-targeting activity. A growing number documents have shown some mentioned exhibited a broad spectrum cytotoxic activity against cells but not normal mammalian entitled peptides. Due solubility, strong penetration, selectivity, ability be used alone conjunction with other medications, potential become very successful treatments future. This review provided overview studies concerning peptide classification, modes action, also summarized developed for targeting different types malignancies. role silico methods artificial intelligence design discovery was briefly explained. Additionally, current addressed challenges utilizing therapy highlighted currently undergoing clinical trials.
Language: Английский
Citations
0
Alzheimer s Research & Therapy, Journal Year: 2025, Volume and Issue: 17(1)
Published: April 5, 2025
Alzheimer's disease (AD) is a neurodegenerative disease. Amyloid β-protein (Aβ) one of the key pathological features AD, which cytotoxic and can damage neurons, thereby causing cognitive dysfunction. Photobiomodulation (PBM) non-invasive physical therapy that induces changes in intrinsic mechanisms cells tissues through low-power light exposure. Although PBM has been employed treatment effect precise mechanism on AD-induced neurological are still unclear. In vivo experiments, (808 nm, 20 mW/cm2) was used to continuously interfere with APP/PS1 mice for 6 weeks, then their function AD were evaluated. vitro lipopolysaccharide (LPS) induce microglia model inflammation, polarization status phagocytic Aβ ability Hexokinase 2 (HK2) inhibitor 3-bromopyruvate (3BP) study mitochondrial energy metabolism microglia. further ameliorates impairment by alleviating neuroinflammation neuronal apoptosis, attenuating nerve damage. addition, also reduce promoting microglial anti-inflammatory phenotypic polarization; Promotes clearance enhancing engulf Aβ. Among them, regulates inhibits may be related its regulation metabolism, promotion oxidative phosphorylation, inhibition glycolysis. neuroinflammatory response repairing Aβ-induced Mitochondrial plays an important role improving injury mice. This provides theoretical support subsequent application AD.
Language: Английский
Citations
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Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 5, 2025
Language: Английский
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Stresses, Journal Year: 2025, Volume and Issue: 5(2), P. 26 - 26
Published: April 4, 2025
Cellular stressors have been demonstrated to exert a substantial influence on the functionality of organelles, thereby impacting cellular homeostasis and contributing development disease pathogenesis. This review aims examine impact diverse stressors, including environmental, chemical, biological, physical factors, critical organelles such as cell membrane, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, membrane-less organelles. The intricate molecular mechanisms underlying stress responses, encompassing oxidative stress, protein misfolding, metabolic reprogramming, capacity elicit adaptive responses or culminate in pathological conditions. interplay between these organelle dysfunction has implicated myriad diseases, neurodegenerative disorders, cancer, immune-related pathologies. A comprehensive understanding by which respond can offer valuable insights into therapeutic strategies aimed at mitigating damage.
Language: Английский
Citations
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Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: April 15, 2025
Language: Английский
Citations
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Redox Biology, Journal Year: 2024, Volume and Issue: 73, P. 103197 - 103197
Published: May 16, 2024
Astrocytes are the major glial cells in human brain and provide crucial metabolic trophic support to neurons. The amyloid-β peptide (Aβ) alter morphological functional properties of astrocytes induce inflammation calcium dysregulation, contributing Alzheimer's disease (AD) pathology. Recent studies highlight role Toll-like receptor (TLR) 4/nuclear factor kappa-light-chain-enhancer activated B (NF-κB) signaling inflammation. Reactive oxygen species (ROS) generated due Aβ, apoptosis worsening AD progression. Astrocytic cell surface receptors, such as purinergic receptors (P2Y1 P2Y2), metabotropic glutamate (mGLUR)5, α7 nicotinic acetylcholine (α7nAChR), N-methyl-d-aspartate (NMDARs), have been suggested interact with inositol trisphosphate (IP3R) on endoplasmic reticulum (ER) Ca2+ movement from ER cytoplasm, causing dysregulation. We found that citrus flavonoid nobiletin (NOB) protected primary Aβ42-induced cytotoxicity inhibited TLR4/NF-κB rat astrocytes. NOB was regulate ROS levels through Keap1-Nrf2 pathway. P2Y1, P2Y2, mGLUR5, α7nAChR, NMDARs induced intracellular by activating IP3R regulated them, thereby regulating levels. Molecular docking analysis revealed a possible interaction between regulation. Furthermore, RNA sequencing various NOB-mediated biological pathways, AD-presenilin, AD-amyloid secretase, Wnt pathway, suggesting neuroprotective roles NOB. To conclude, is promising therapeutic agent for works modulating pathology at
Language: Английский
Citations
3
Oxygen, Journal Year: 2024, Volume and Issue: 4(3), P. 325 - 337
Published: Aug. 19, 2024
Oxidative stress, characterized by an imbalance between the production of reactive oxygen species and body’s antioxidant defenses, plays important role in pathogenesis various health conditions, including cancer neurological disorders. For example, excessive ROS can lead to mutations, genomic instability, uncontrolled cell proliferation cancer. In disorders, oxidative stress contributes neuronal damage, inflammation, progression diseases such as Alzheimer’s Parkinson’s diseases. Adenosine, a nucleoside involved energy transfer signal transduction, is crucial maintaining cellular homeostasis. Its extends modulating stress. Adenosine receptors are implicated physiological processes pathophysiology The interplay adenosine signaling complex critical. modulate responses, providing therapeutic potential for conditions where key player. Understanding this connection opens up avenues novel strategies targeting mitigate damage.
Language: Английский
Citations
2